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  4. Recombinant Dog Protein amnionless (AMN), partial

Recombinant Dog Protein amnionless (AMN), partial

  • 货号：
    CSB-YP757781DO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP757781DO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP757781DO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP757781DO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP757781DO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    AMN
  • Uniprot No.：
  • 别名：
    AMNProtein amnionless [Cleaved into: Soluble protein amnionless]
  • 种属：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Membrane-bound component of the endocytic receptor formed by AMN and CUBN. Required for normal CUBN glycosylation and trafficking to the cell surface. The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12. Required for normal CUBN-mediated protein transport in the kidney.
  • 基因功能参考文献：
    1. Imerslund-Grasbeck syndromes due to an in-frame deletion of 33 nucleotides in exon 10 of AMN or a homozygous substitution in the AMN translation initiation codon abrogate AMN expression and block cubilin processing and targeting to the apical membrane. PMID: 15845892
    2. AMN interacts with the EGF domains of cubilin for membrane attachment and export from the endoplasmic reticulum, while extracellular cubilin does apical sorting of the complex in a carbohydrate-dependent manner PMID: 15976000
  • 相关疾病：
    Defects in AMN could be a cause of a canine form of megaloblastic anemia 1 (MGA1).
  • 亚细胞定位：
    Apical cell membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Endosome membrane. Membrane, coated pit.; [Soluble protein amnionless]: Secreted.
  • 组织特异性：
    Detected in kidney (at protein level). Detected in kidney and ileum.
  • 数据库链接：

    KEGG: cfa:403434

    UniGene: Cfa.33575