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  4. Recombinant Dog Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1), partial

Recombinant Dog Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1), partial

  • 中文名称：
    熟悉的犬SEC61A1重组蛋白
  • 货号：
    CSB-YP020956DO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    熟悉的犬SEC61A1重组蛋白
  • 货号：
    CSB-EP020956DO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    熟悉的犬SEC61A1重组蛋白
  • 货号：
    CSB-EP020956DO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    熟悉的犬SEC61A1重组蛋白
  • 货号：
    CSB-BP020956DO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    熟悉的犬SEC61A1重组蛋白
  • 货号：
    CSB-MP020956DO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    SEC61A1; Protein transport protein Sec61 subunit alpha isoform 1; Sec61 alpha-1
  • 种属：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis. Plays a critical role in nephrogenesis, specifically at pronephros stage.
  • 基因功能参考文献：
    1. CaM binding to the cytosolic N-terminus of Sec61alpha is involved in limiting Ca(2+)-leakage from the ER in C. familiaris but not S. cerevisiae. PMID: 21558796
    2. Calmodulin binds to a conserved motif of the Sec61 alpha subunit in a calcium-dependent and sequence-specific manner. PMID: 21102557
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SecY/SEC61-alpha family
  • 数据库链接：

    KEGG: cfa:404006

    STRING: 9615.ENSCAFP00000006087

    UniGene: Cfa.3877