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  4. Recombinant Drosophila melanogaster C-terminal-binding protein (CtBP)

Recombinant Drosophila melanogaster C-terminal-binding protein (CtBP)

  • 中文名称：
    Recombinant Drosophila melanogaster C-terminal-binding protein(CtBP),Yeast
  • 货号：
    CSB-YP526144DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster C-terminal-binding protein(CtBP),Yeast
  • 货号：
    CSB-EP526144DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster C-terminal-binding protein(CtBP),Yeast
  • 货号：
    CSB-EP526144DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster C-terminal-binding protein(CtBP),Yeast
  • 货号：
    CSB-BP526144DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster C-terminal-binding protein(CtBP),Yeast
  • 货号：
    CSB-MP526144DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CtBP
  • Uniprot No.：
  • 别名：
    CtBP; CG7583C-terminal-binding protein; CtBP protein; dCtBP
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-476
  • 氨基酸序列
    MDKNLMMPKR SRIDVKGNFA NGPLQARPLV ALLDGRDCSI EMPILKDVAT VAFCDAQSTS EIHEKVLNEA VGALMWHTII LTKEDLEKFK ALRIIVRIGS GTDNIDVKAA GELGIAVCNV PGYGVEEVAD TTMCLILNLY RRTYWLANMV REGKKFTGPE QVREAAHGCA RIRGDTLGLV GLGRIGSAVA LRAKAFGFNV IFYDPYLPDG IDKSLGLTRV YTLQDLLFQS DCVSLHCTLN EHNHHLINEF TIKQMRPGAF LVNTARGGLV DDETLALALK QGRIRAAALD VHENEPYNVF QGALKDAPNL ICTPHAAFFS DASATELREM AATEIRRAIV GNIPDVLRNC VNKEYFMRTP PAAAAGGVAA AVYPEGALHH RAHSTTPHDG PHSTTNLGST VGGGPTTVAQ AAAAAVAAAA AAALLPSPVP SHLSPQVGGL PLGIVSSQSP LSAPDPNNHL SSSIKTEVKA ESTEAP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Corepressor targeting diverse transcription regulators. Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression.
  • 基因功能参考文献：
    1. We found that TCF7L1 recruits the C-terminal binding protein (CtBP) and histone deacetylase 1 (HDAC1) to the DKK4 promoter to repress DKK4 gene expression. In the absence of TCF7L1, TCF7L2 and beta-catenin occupancy at the DKK4 promoter is stimulated and DKK4 expression is increased. These findings uncover a critical role for TCF7L1 in repressing DKK4 gene expression to promote the oncogenic potential of CRCs. PMID: 28450117
    2. These results support a model where CtBP is a gene-specific regulator of Wingless signalling, with some targets requiring CtBP dimers for inhibition while other targets utilize CtBP monomers for activation of their expression. PMID: 21468031
    3. Results indicate that the structural and enzymatic features of C-terminal binding protein are critical for modulating this protein's activity in diverse developmental settings. PMID: 21078873
    4. CtBp proteins repress transcription in a histone deacetylase-dependent or independent manner. PMID: 11864595
    5. Reduction of dCtBP function enhances H mutant phenotypes and suppresses N phenotypes in the adult mechanosensory bristle. This activity of gro is surprising, because it is directed oppositely to its traditionally defined role as a neurogenic gene. PMID: 12154126
    6. YY1 protein and Polycomb group (PcG) protein require this repressor protein for repression in vivo. PMID: 12628927
    7. These findings provide evidence that competition is distinct from quenching and direct repression; quenching and direct repression depend on CtBP, whereas competition does not. PMID: 12748300
    8. Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities. PMID: 12888527
    9. CtBP contributes quantitatively, rather than qualitatively, to overall repression function. PMID: 15128671
    10. requirement for Gro and CtBP in Hairless-mediated repression PMID: 16287856
    11. Here, we discuss the cytoplasmic roles of the CtBPs and the possible mechanisms that enable them to switch between cell compartments and multiple functions. PMID: 16483777
    12. AChE's 3' alternative splicing, and the corresponding changes in AChE-S/CtBP interactions, thus emerge as being actively involved in controlling hematopoiesis PMID: 17476278
    13. the ancestral dehydrogenase activity is not required for CtBP function, and NAD binding may play a regulatory, rather than catalytic, role PMID: 17964573
    14. These data, taken together, suggest that AN is functionally distinct from dCtBP. PMID: 17972097
    15. dCtBP is part of a gene circuitry that controls the patterning and differentiation of the fly peripheral nervous system via multiple mechanisms PMID: 18992810

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    D-isomer specific 2-hydroxyacid dehydrogenase family
  • 数据库链接：

    KEGG: dme:Dmel_CG7583

    STRING: 7227.FBpp0099514

    UniGene: Dm.2246