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  4. Recombinant Drosophila melanogaster Cell death protein rpr (rpr)

Recombinant Drosophila melanogaster Cell death protein rpr (rpr)

  • 中文名称：
    黑腹果蝇rpr重组蛋白
  • 货号：
    CSB-YP634510DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇rpr重组蛋白
  • 货号：
    CSB-EP634510DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇rpr重组蛋白
  • 货号：
    CSB-EP634510DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇rpr重组蛋白
  • 货号：
    CSB-BP634510DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇rpr重组蛋白
  • 货号：
    CSB-MP634510DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    rpr
  • Uniprot No.：
  • 别名：
    rpr; CG4319; Cell death protein rpr; Protein reaper
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-65
  • 氨基酸序列
    MAVAFYIPDQ ATLLREAEQK EQQILRLRES QWRFLATVVL ETLRQYTSCH PKTGRKSGKY RKPSQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Activator of apoptosis, as well as grim and hid, that acts on the effector Dredd.
  • 基因功能参考文献：
    1. The rapid induction of apoptosis requires the P53 and is mediated by a stress-responsive regulatory region upstream of reaper. The rapid induction of apoptosis is responsible for preventing the expression of viral genes and blocking the infection. PMID: 23408884
    2. dBruce physically interacts with Reaper, dependent upon Reaper's IAP-binding (IBM) and GH3 motifs. PMID: 21886178
    3. Eliminating Foxo, together with inhibition of reaper family proapoptotic genes, promotes long-term survival of neuroblasts and sustains neurogenesis in the adult mushroom body, the center for learning and memory. PMID: 20346676
    4. Rpr mediates programmed cell death during drosophila development PMID: 11853767
    5. the central nervous systems of rpr null flies were very enlarged. This was due to the inappropriate survival of both larval neurons and neuroblasts. PMID: 11880355
    6. Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition. PMID: 12021770
    7. regulation by inhibitor of apoptosis protein-mediated ubiquination PMID: 12446669
    8. Bifunctional killing activity is encoded by conserved reaper proteins. PMID: 15002042
    9. Internal ribosome entry site drives cap-independent translation of rpr mRNA in Drosophila embryos. PMID: 15496524
    10. Reaper is located downstream of LKB1 and is invloved in LKB1 sependent apoptosis. PMID: 16273080
    11. Reaper is the first known cellular ribosomal binding factor with the potential to allow selective translation of mRNAs initiating at alternative start codons or from certain IRES elements PMID: 16429152
    12. Data provide a function for the GH3 domain in conferring protein-lipid interactions, demonstrate that both Reaper binding and mitochondrial localization are required for accelerated IAP degradation. PMID: 17998202
    13. Data show that all factors studied have very specific temporal and spatial effects on rpr transcription. PMID: 19602391

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  • 数据库链接：

    KEGG: dme:Dmel_CG4319

    STRING: 7227.FBpp0074886

    UniGene: Dm.2529