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  4. Recombinant Drosophila melanogaster DnaJ protein homolog 1 (DnaJ-1)

Recombinant Drosophila melanogaster DnaJ protein homolog 1 (DnaJ-1)

  • 中文名称：
    黑腹果蝇DnaJ-1重组蛋白
  • 货号：
    CSB-YP634500DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇DnaJ-1重组蛋白
  • 货号：
    CSB-EP634500DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇DnaJ-1重组蛋白
  • 货号：
    CSB-EP634500DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇DnaJ-1重组蛋白
  • 货号：
    CSB-BP634500DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇DnaJ-1重组蛋白
  • 货号：
    CSB-MP634500DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DnaJ-1
  • Uniprot No.：
  • 别名：
    DnaJ-1; DROJ1; CG10578DnaJ protein homolog 1; DROJ1
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-334
  • 氨基酸序列
    MGKDFYKILG LERKASDDEI KKAYRKLALK YHPDKNKSPQ AEERFKEIAE AYEVLSDKKK RDIFDNYGED GLKGGQPGPD GGGQPGAYTY QFHGDPRATF AQFFGSSDPF GAFFTGGDNM FSGGQGGNTN EIFWNIGGDD MFAFNAQAPS RKRQQDPPIE HDLFVSLEEV DKGCIKKMKI SRMATGSNGP YKEEKVLRIT VKPGWKAGTK ITFPQEGDSA PNKTPADIVF IIRDKPHSLF KREGIDLKYT AQISLKQALC GALVSVPTLQ GSRIQVNPNH EIIKPTTTRR INGLGLPVPK EPSRRGDLIV SFDIKFPDTL APSLQNQLSE LLPN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Additional studies established that the increased toxicity upon mutating UbS2 stems from disrupting the autoprotective role that pathogenic ataxin-3 has against itself, which depends on the co-chaperone, DnaJ-1. Our data reveal a previously unrecognized balance between pathogenic and potentially therapeutic properties of the ataxin-3-Rad23 interaction; they highlight this interaction as critical for the toxicity of the S PMID: 28158474
    2. Through DnaJ-1, our data connect ataxin-3 and Rad23 to protective processes involved with protein folding rather than increased turnover of toxic polyQ species. PMID: 26007638
    3. Expression of DnaJ-1 potently suppresses alpha1ACT-dependent degeneration , concomitant with decreased aggregation of the pathogenic protein. Mutating the nuclear importer karyopherin a3 also leads to reduced toxicity from pathogenic CACNA1A PMID: 25954029
    4. HSP40 and HSP110 function together in protein homeostasis control. PMID: 24091676
    5. A high positive correlation was found between the levels of Hsp40 expression and scores of basal and induced thermotolerance, implying a significant contribution of Hsp40 gene in thermoadaptation. PMID: 21505045

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  • 亚细胞定位：
    Cytoplasm.
  • 数据库链接：

    KEGG: dme:Dmel_CG10578

    STRING: 7227.FBpp0076829

    UniGene: Dm.2839