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  4. Recombinant Drosophila melanogaster Homeotic protein caudal (cad)

Recombinant Drosophila melanogaster Homeotic protein caudal (cad)

  • 中文名称：
    Recombinant Drosophila melanogaster Homeotic protein caudal(cad),Yeast
  • 货号：
    CSB-YP362588DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Homeotic protein caudal(cad),Yeast
  • 货号：
    CSB-EP362588DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Homeotic protein caudal(cad),Yeast
  • 货号：
    CSB-EP362588DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Homeotic protein caudal(cad),Yeast
  • 货号：
    CSB-BP362588DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Homeotic protein caudal(cad),Yeast
  • 货号：
    CSB-MP362588DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    cad
  • Uniprot No.：
  • 别名：
    cad; CG1759Homeotic protein caudal
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-427
  • 氨基酸序列
    MVSHYYNTLP YTQKHSAANL AYASAAGQPW NWTPNYHHTP PNHQFLGDVD SSHAAHHAAA AHQMYYNSHH MFHSAAAASA GEWHSPASST ADNFVQNVPT SAHQLMQQHH HHHAHASSSS ASSGSSSSGG APGAPQLNET NSSIGVGGAG GGGGVGGATD GGPGSAPPNH QQHIAEGLPS PPITVSGSEI SSPGAPTSAS SPHHHLAHHL SAVANNNNNN NNNNNSPSTH NNNNNNNSVS NNNRTSPSKP PYFDWMKKPA YPAQPQPGKT RTKDKYRVVY TDFQRLELEK EYCTSRYITI RRKSELAQTL SLSERQVKIW FQNRRAKERK QNKKGSDPNV MGVGVQHADY SQLLDAKAKL EPGLHLSHSL AHSMNPMAAM NIPAMRLHPH LAAHSHSLAA VAAHSHQLQQ QHSAQMSAAA AVGTLSM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Caudal (cad) is one of a number of transcription factors controlling segmentation of the embryo. Further transcriptional regulation via a 5' flanking region containing DNA replication-related elements (DRE) and by dref also regulated by trh and tgo via the CNS midline element. Alongside Bicoid (bcd), caudal forms concentration gradients down the anterior-posterior (A-P) axis providing positional information and subsequent induction of the gap genes. Plays a role in gastrulation/germ band extension, hindgut morphogenesis, positive regulation of cell proliferation, genital disk development and pattern formation. Acts as a key regulator of the Hox gene network and activates transcription via the downstream core promoter element (DPE) relative to the TATA box. Plays a role in the establishment of the hindgut and in the invagination of the hindgut primordium during gastrulation. These effects on the gut are achieved by acting combinatorially at the posterior of the embryo to activate transcription of different targets including fog, fkh and wg. Caudal is involved in regulation of proliferation through transactivation of the E2F gene. Postembryonically its function is mostly restricted to the intestine where it regulates antimicrobial peptide (AMP) levels preserving the normal gut flora.
  • 基因功能参考文献：
    1. In this study, ChIP/chip datasets are analyzed using the corresponding PWMs for the well-studied TFs; CAUDAL, HUNCHBACK, KNIRPS and KRUPPEL, to determine the distribution of predicted binding sites. All four TFs are critical regulators of gene expression along the anterio-posterior axis in early Drosophila development PMID: 27264535
    2. Using a systematic series of deletion mutants (all containing the intact DNA-binding homeodomain) we discovered that the C-terminal region of Caudal contributes to the preferential activation of the fushi tarazu (ftz) Caudal target gene. PMID: 26018075
    3. Bicoid acts through a 63 nt response element in the caudal 3' untranslated region that includes a single miR-2 target site. Four predicted Bicoid splice isoforms are capable of caudal repression; all require the microRNA target for repression. PMID: 23910663
    4. Abdominal-B and caudal inhibit the formation of specific neuroblasts in the Drosophila tail region. PMID: 23903193
    5. Bicoid recruits Bin3 to the caudal 3' UTR. PMID: 21262214
    6. Bicoid associates with the 5'-cap-bound complex of caudal mRNA and represses translation. PMID: 12368268
    7. The caudal homeodomain protein activates Drosophila E2F gene expression. PMID: 12466526
    8. In this study, we have identified the binding sites for bHLH-PAS proteins, referred to as CNS midline element (CME), in the 5'-flanking region of the Drosophila caudal gene. PMID: 17207870
    9. study shows that the intestinal homeobox gene Caudal regulates the commensal-gut mutualism by repressing nuclear factor kappa B-dependent antimicrobial peptide genes PMID: 18218863
    10. Age- and oxidative-stress-related upregulation of the caudal gene is mediated by the NF-kappaB binding site located in the 5'-flanking region of the caudal gene. PMID: 18656526

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Caudal homeobox family
  • 组织特异性：
    Maternally localized in an anteroposterior gradient in the syncytial blastoderm. Also expressed in the pole cells. Zygotically localized in the primordia of the terminal abdominal segment, the hindgut and in the posterior midgut rudiment. Expressed in the
  • 数据库链接：

    KEGG: dme:Dmel_CG1759

    STRING: 7227.FBpp0080942

    UniGene: Dm.2073