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  4. Recombinant Drosophila melanogaster Protein ORD (ord)

Recombinant Drosophila melanogaster Protein ORD (ord)

  • 货号：
    CSB-YP637592DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP637592DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP637592DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP637592DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP637592DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ord
  • Uniprot No.：
  • 别名：
    ord; CG3134; Protein ORD; Orientation disrupter protein
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-479
  • 氨基酸序列
    MYGETTLNKN HVIKFIKLKI NNCLGCDEVE INFSKADNVH IIIYSLVTDM AKDLPAVTPV AQAILLLCSL TYPDSDSLET IPQLKIGKGS VSMSFKVYPV NKEEETEPES ESDLDEGPST SKQALERMVQ RAERKAKEAS TRNVHSKGIY VNVERRFDMY FALDTVSYYI NGGKRQSCPL PEFHAKFFVR PQHSINLLRQ LHEKCSGNWL KVIQSDGDGD AFKKFKDPDS PFETFVKLFE SNPIKPNDMM GKLAKTCLHV NEAVRLTERE FILEVFNQVR HIFEYITAQE YTVWFLVPCL GDKDQLRSKT LEDFDLTKVR TSIRRAGDTS NIWWDHTDHN IKDILLVAFQ LDLATHVNQS VLVISHLETL AEFSTMQYVT AFFMNDFYAK KNTEPKWICH RYLERIIDVA LFLGVIVIIE YPSAFTLLQE GRHLIKCFQK ENADSSRTSQ WEIFEDVVKE NESDLEFLKE AVGKVQQNV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential for proper maintenance of sister-chromatid cohesion in both male and female meiosis. Mutations in ord cause premature separation of the sister chromatids in meiosis I and random segregation in both meiotic divisions. Required for chiasma maintenance in female meiosis. Mutations in ord reduce recombination in female meiosis.
  • 基因功能参考文献：
    1. Results suggest that association of orientation disruptor (ORD) with meiotic chromosomes during mid to late G2 is required to maintain sister-chromatid cohesion during prophase condensation. PMID: 12429833
    2. Results suggest that orientation disruptor (ord) activity suppresses sister chromatid exchange and stimulates inter-homologue crossovers, promoting homologue bias during meiotic recombination in Drosophila. PMID: 15007062
    3. If ORD activity is more severely disrupted, achiasmate chromosomes with the normal amount of pericentric heterochromatin exhibit increased nondisjunction when oocytes age. PMID: 19204374
  • 亚细胞定位：
    Nucleus. Chromosome. Chromosome, centromere. Note=In male meiosis it assembles onto chromosomes in late G2 of the meiotic cell cycle. It remains at the centromeres after chromosome condensation, through the meiosis I division until the separation of sister chromatids at anaphase II.
  • 数据库链接：

    KEGG: dme:Dmel_CG3134

    STRING: 7227.FBpp0071956

    UniGene: Dm.3857