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  4. Recombinant Drosophila melanogaster Protein Wnt-2 (Wnt2)

Recombinant Drosophila melanogaster Protein Wnt-2 (Wnt2)

  • 货号：
    CSB-YP026133DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP026133DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP026133DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP026133DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP026133DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Wnt2; Wnt-2; CG1916; Protein Wnt-2; dWnt-2
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-352
  • 氨基酸序列
    FTSVMLC GRIPGLTPGQ RNMCREMPDA LIALGEGHQL GAQECQHQFR GHRWNCSEVW QRNVFAHVIP TASREAAYTY AIASAGAAYA VTAACARGNI STCGCDVRHK ATPTGGGTPD EPWKWGGCSA DVDFGMRYAR RFMDARELER DSRTLMNLHN NRAGRTLVKK MLRTDCKCHG VSGSCVMKTC WKSLPPFRLV GDRLMLKYQK AKTVQAVKGK RGLRLVLSRK KHAGTARAQK PVLDWPKRME LIYLEASPNY CERSLQTGSQ GTSGRTCQRT GHGPQSCDLL CCGRGHNTQH IRRTTQCRCQ FRWCCEVKCD ECDESYEEFT CK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May function in gonadogenesis and limb development. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation.
  • 基因功能参考文献：
    1. We discovered an otk paralog (otk2, CG8964), which is co-expressed with otk throughout embryonic and larval development. Otk and Otk2 bind to each other and form complexes with Frizzled, Frizzled2 and Wnt2, pointing to a function as Wnt co-receptors. PMID: 25010066
    2. Mutations in Wnt2 alter presynaptic motor neuron morphology and presynaptic protein localization at the neuromuscular junction. PMID: 20856675
    3. DWnt-2 promotes correct patterning of direct flight muscles through a mechanism that is independent of the attachment site differentiation initiated by stripe. PMID: 11884040
    4. It activates beta-catenin-independent pathway, such as planar cell polarity pathway, calcium signaling. (review) PMID: 19195220
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Wnt family
  • 组织特异性：
    Dynamic expression pattern during embryogenesis. Expression is predominantly segmented, with expression also seen in the limb primordia and presumptive gonads. In embryonic tracheal cells, expression is close to and dorsal to the tracheal placode.
  • 数据库链接：

    KEGG: dme:Dmel_CG1916

    STRING: 7227.FBpp0087596

    UniGene: Dm.4787