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  4. Recombinant Drosophila melanogaster Protein deadpan (dpn)

Recombinant Drosophila melanogaster Protein deadpan (dpn)

  • 中文名称：
    黑腹果蝇dpn重组蛋白
  • 货号：
    CSB-YP637696DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇dpn重组蛋白
  • 货号：
    CSB-EP637696DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇dpn重组蛋白
  • 货号：
    CSB-EP637696DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇dpn重组蛋白
  • 货号：
    CSB-BP637696DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇dpn重组蛋白
  • 货号：
    CSB-MP637696DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    dpn
  • Uniprot No.：
  • 别名：
    dpn; CG8704Protein deadpan
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-435
  • 氨基酸序列
    MDYKNDINSD DDFDCSNGYS DSYGSNGRMS NPNGLSKAEL RKTNKPIMEK RRRARINHCL NELKSLILEA MKKDPARHTK LEKADILEMT VKHLQSVQRQ QLNMAIQSDP SVVQKFKTGF VECAEEVNRY VSQMDGIDTG VRQRLSAHLN QCANSLEQIG SMSNFSNGYR GGLFPATAVT AAPTPLFPSL PQDLNNNSRT ESSAPAIQMG GLQLIPSRLP SGEFALIMPN TGSAAPPPGP FAWPGSAAGV AAGTASAALA SIANPTHLND YTQSFRMSAF SKPVNTSVPA NLPENLIHTL PGQTQLPVKN STSPPLSPIS SISSHCEESR AASPTVDVMS KHSFAGVFST PPPTSAETSF NTSGSLNLSA GSHDSSGCSR PLAHLQQQQV SSTSGIAKRD REAEAESSDC SLDEPSSKKF LAGAIEKSSS AWRPW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor of genes that require a bHLH protein for their transcription. In the larval brain, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm together with other self-renewal transcriptional repressors such as klu and E(spl)mgamma-HLH. As part of its role in neuroblasts development, has been shown to be a direct target of the Notch signaling pathway, however might work also independently of N/Notch. In the developing larval and pupal brain, required for mushroom body differentiation. Involved in sex determination and SXL transcription repression when in complex with the corepressor protein Groucho.
  • 基因功能参考文献：
    1. Dpn contributes to the establishment of Cut expression. PMID: 24086596
    2. Data suggest that Dpn plays important roles in maintaining NB self-renewal and specification of type II NBs in larval brains and that Dpn and Notch function independently in regulating type II NB proliferation and specification. PMID: 23056424
    3. Dpn is a partner and target of CK2, and raises the possibility that its repressor functions might also be regulated by phosphorylation. PMID: 16342413
    4. Groucho and associated maternal and zygotic bHLH repressors define the threshold X-linked signal element gene concentrations needed to activate Sex-lethal establishment promoter and they participate directly in sex signal amplification. PMID: 18773886
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: dme:Dmel_CG8704

    STRING: 7227.FBpp0087879

    UniGene: Dm.525