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  4. Recombinant Drosophila sechellia Protein hedgehog (hh)

Recombinant Drosophila sechellia Protein hedgehog (hh)

  • 货号：
    CSB-YP461552DMG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP461552DMG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP461552DMG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP461552DMG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP461552DMG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    hh
  • Uniprot No.：
  • 别名：
    hh; GM23589; Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product]
  • 种属：
    Drosophila sechellia (Fruit fly)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    79-465
  • 氨基酸序列
    CG PGRGLGRHRA RNLYPLVLKQ TIPNLSEYTN SASGPLEGVI RRDSPKFKDL VPNYNRDILF RDEEGTGADR LMSKRCKEKL NVLAYSVMNE WPGIRLLVTE SWDEDYHHGQ ESLHYEGRAV TIATSDRDQS KYGMLARLAV EAGFDWVSYV SRRHIYCSVK SDSSISSHVH GCFTPESTAL LESGVRKPLG ELSIGDRVLS MTANGQAVYS EVILFMDRNL EQMQNFVQLH TDGGAVLTVT PAHLVSVWQP ESQKLTFVFA DRIEEKNQVL VRDVETGELR PQRVVKVGSV RSKGVVAPLT REGTIVVNSV AASCYAVINS QSLAHWGLAP MRLLSTLEAW LPAKEQLHSS PKVVSSAQQQ NGIHWYANAL YKVKDYVLPQ SWRHD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu).; The hedgehog protein N-product constitutes the active species in both local and long-range signaling, whereas the C-terminal product has no signaling activity. It acts as a morphogen, and diffuses long distances despite its lipidation. Heparan sulfate proteoglycans of the extracellular matrix play an essential role in diffusion. Lipophorin is required for diffusion, probably by acting as vehicle for its movement, explaining how it can spread over long distances despite its lipidation.; The hedgehog protein C-product, which mediates the autocatalytic activity, has no signaling activity.
  • 亚细胞定位：
    Nucleus. Cytoplasm.; [Protein hedgehog N-product]: Cell membrane; Lipid-anchor; Extracellular side.; [Protein hedgehog C-product]: Secreted, extracellular space.
  • 蛋白家族：
    Hedgehog family
  • 数据库链接：

    KEGG: dse:Dsec_GM23589