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  4. Recombinant Escherichia coli Periplasmic protein CpxP (cpxP)

Recombinant Escherichia coli Periplasmic protein CpxP (cpxP)

  • 中文名称：
    Recombinant Escherichia coli Periplasmic protein CpxP(cpxP),Yeast
  • 货号：
    CSB-YP365106ENV
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Escherichia coli Periplasmic protein CpxP(cpxP),Yeast
  • 货号：
    CSB-EP365106ENV
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Escherichia coli Periplasmic protein CpxP(cpxP),Yeast
  • 货号：
    CSB-EP365106ENV-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Escherichia coli Periplasmic protein CpxP(cpxP),Yeast
  • 货号：
    CSB-BP365106ENV
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Escherichia coli Periplasmic protein CpxP(cpxP),Yeast
  • 货号：
    CSB-MP365106ENV
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    cpxP
  • Uniprot No.：
  • 别名：
    cpxP; yiiO; b4484; JW5558Periplasmic protein CpxP; ORF_o167; Periplasmic accessory protein CpxP
  • 种属：
    Escherichia coli (strain K12)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-166
  • 氨基酸序列
    AEVGSGDNW HPGEELTQRS TQSHMFDGIS LTEHQRQQMR DLMQQARHEQ PPVNVSELET MHRLVTAENF DENAVRAQAE KMANEQIARQ VEMAKVRNQM YRLLTPEQQA VLNEKHQQRM EQLRDVTQWQ KSSSLKLLSS SNSRSQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as an auxiliary protein in the Cpx two-component envelope stress response system, helping modulate the Cpx response systems response to some inducers. Binds the periplasmic domain of sensor histidine kinase CpxA, inhibiting induction of the Cpx envelope stress response in the absence of inducer; overexpression decreases Cpx pathway activity. Some periplasmic stimulii (shown for P pili subunit PapE and probably 0.3 M NaCl) increase CpxP's susceptibility to DegP, leading to CpxP degradation, inducing the Cpx pathway. Aids in combating extracytoplasmic protein-mediated toxicity. Overexpression leads to degradation by DegP of misfolded P pili subunits in the periplasm (tested using PapE). Inhibits autophosphorylation of CpxA in reconstituted liposomes by 50% but has no effect on phosphatase activity of CpxA. Has mild protein chaperone activity.
  • 基因功能参考文献：
    1. The Cpx-TCS within the complex regulatory network in the E. coli response to aminoglycoside-caused stress. PMID: 28923010
    2. We determined that K298 of RNA polymerase alpha is specifically required for glucose-induced cpxP transcription. PMID: 21696463
    3. periplasmic expression could be inhibited by sequence elements in the early coding signal sequence region of cpxP PMID: 17905837
  • 亚细胞定位：
    Periplasm.
  • 蛋白家族：
    CpxP/Spy family
  • 数据库链接：

    KEGG: ecj:JW5558

    STRING: 316385.ECDH10B_4103