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  4. Recombinant F-box/SPRY domain-containing protein 1 (fsn-1)

Recombinant F-box/SPRY domain-containing protein 1 (fsn-1)

  • 货号：
    CSB-YP621106CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP621106CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP621106CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP621106CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP621106CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    fsn-1
  • Uniprot No.：
  • 别名：
    fsn-1; C26E6.5F-box/SPRY domain-containing protein 1; F-box synaptic protein 1
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-332
  • 氨基酸序列
    MAENDGETIV PDEQCNLTAS TPMKSSGLEQ VESPKERKTS MVECDDEGNP SSGTPDESPK QLTPHSIPPR RRRSPRRPEV SASRLPLKVL NQIFQYLPLK DLRSAMLTCH SWNNALSMED SDIWQYLLGK KLPEAAVSDP FLLAELGSAK KKLRAWYFAW NTSDISRNNY IRTNGFTVHR QPVAQSTDGV RGKRGISKGV HAFDITWDGP LGTVAVVGIA TKHAALHCVG YVALLGSDDQ SWGWNLVDNV LMHNGAQLGV YPKMNNPPKY EVGDKIRLII DCDTHVAYFE RNSEFLGIAF NHIPPLRLYP AVCAVYGNTE VTMVYVGSPQ MG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and ALM neurons.
  • 基因功能参考文献：
    1. region of RPM-1 that is sufficient in binding to FSN-1 PMID: 25326385
    2. FSN-1 may negatively regulate insulin/IGF signalling, in part, through EGL-3-dependent insulin-like ligand processing. PMID: 23665919
    3. identification of FSN-1, a novel F-box protein that is required in presynaptic neurons for the restriction and/or maturation of synapses in Caenorhabditis elegans PMID: 15208641
    4. Identification of FSN-1 as a negative regulator of cep-1-dependent germ cell apoptosis. PMID: 18340346
  • 亚细胞定位：
    Cell junction, synapse.
  • 蛋白家族：
    FBXO45/Fsn family
  • 组织特异性：
    Expressed in GABAergic neuromuscular junctions (NMJs).
  • 数据库链接：

    KEGG: cel:CELE_C26E6.5

    STRING: 6239.C26E6.5

    UniGene: Cel.22711