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  4. Recombinant Fowl adenovirus A serotype 1 Protein GAM-1 (8)

Recombinant Fowl adenovirus A serotype 1 Protein GAM-1 (8)

  • 中文名称：
    Recombinant Fowl adenovirus A serotype 1 Protein GAM-1(8),Yeast
  • 货号：
    CSB-YP714520FCL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Fowl adenovirus A serotype 1 Protein GAM-1(8),Yeast
  • 货号：
    CSB-EP714520FCL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Fowl adenovirus A serotype 1 Protein GAM-1(8),Yeast
  • 货号：
    CSB-EP714520FCL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Fowl adenovirus A serotype 1 Protein GAM-1(8),Yeast
  • 货号：
    CSB-BP714520FCL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Fowl adenovirus A serotype 1 Protein GAM-1(8),Yeast
  • 货号：
    CSB-MP714520FCL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    8
  • Uniprot No.：
  • 别名：
    8; Protein GAM-1; Gallus-anti morte protein; Gam1
  • 种属：
    Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps))
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-282
  • 氨基酸序列
    MARNPFRMFP GDLPYYMGTI SFTSVVPVDP SQRNPTTSLR EMVTTGLIFN PNLTGEQLRE YSFSPLVSMG RKAIFADYEG PQRIIHVTIR GRSAEPKTPS EALIMMEKAV RGAFAVPDWV AREYSDPLPH GITHVGDLGF PIGSVHALKM ALDTLKIHVP RGVGVPGYEG LCGTTTIKAP RQYRLLTTGV FTKKDLKRTL PEPFFSRFFN QTPEVCAIKT GKNPFSTEIW CMTLGGDSPA PERNEPRNPH SLQDWARLGV METCLRMSRR GLGSRHHPYH SL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Early protein essential for viral replication. Strong and global transcriptional activator of both viral and cellular genes. Activates transcription by blocking host retinoblastoma protein (RB) and inhibiting the SUMO pathway. Inhibition of host RB leads to the activation of E2F1-dependent transcription and, in particular, of E2F1-regulated S-phase genes. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Blocks the SUMO pathway by targeting the E1 enzyme (SAE1/UBA2 heterodimer) to the ubiquitin-proteasome machinery. Mediates SAE1 degradation possibly through the formation of complexes with either CUL2-elongin BC complex-RBX1 or CUL5-elongin BC complex-RBX1. The degradation of UBA2 is probably a consequent effect of SAE1 disappearance. Inhibits HDAC1 sumoylation, thereby interfering with histone deacetylation mediated by HDAC1, leading to activation of transcription. Mediates induction of heat-shock response. Seems to have an antiapoptotic function.
  • 亚细胞定位：
    Host nucleus.
  • 数据库链接：

    KEGG: vg:1733455