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  4. Recombinant Helicobacter pylori Acid-activated urea channel (ureI)

Recombinant Helicobacter pylori Acid-activated urea channel (ureI)

  • 中文名称：
    幽门螺旋杆菌ureI重组蛋白
  • 货号：
    CSB-YP600591HUV
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    幽门螺旋杆菌ureI重组蛋白
  • 货号：
    CSB-EP600591HUV
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    幽门螺旋杆菌ureI重组蛋白
  • 货号：
    CSB-EP600591HUV-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    幽门螺旋杆菌ureI重组蛋白
  • 货号：
    CSB-BP600591HUV
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    幽门螺旋杆菌ureI重组蛋白
  • 货号：
    CSB-MP600591HUV
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ureI
  • Uniprot No.：
  • 别名：
    ureI; HP_0071; Acid-activated urea channel; Urease accessory protein UreI
  • 种属：
    Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-195
  • 氨基酸序列
    MLGLVLLYVGIVLISNGICGLTKVDPKSTAVMNFFVGGLSIICNIVVITYSALHPTAPVE GAEDIAQVSHHLTSFYGPATGLLFGFTYLYAAINHTFGLDWRPYSWYSLFVAINTIPAAI LSHYSDMLDDHKVLGITEGDWWAIIWLAWGVLWLTAFIENILKIPLGKFTPWLAIIEGIL TAWIPAWLLFIQHWV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for the adaptation of urease activity to the extracellular pH, as in the presence of urea, UreI rapidly enhances the production of ammonia in the extracellular medium when the pH of the medium was decreased to pH5 or below.
  • 基因功能参考文献：
    1. The extent of binding of urea by HpUreI was increased at lower pH. PMID: 21877689
    2. Assembly of a pH-regulatory complex of active urease with UreI provides an advantage for periplasmic buffering. PMID: 19854893
  • 亚细胞定位：
    Cell inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    AmiS/UreI family
  • 数据库链接：

    KEGG: heo:C694_00340

    STRING: 85962.HP0071