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  4. Recombinant Heteractis crispa Analgesic polypeptide HC1

Recombinant Heteractis crispa Analgesic polypeptide HC1

  • 中文名称：
    Recombinant Heteractis crispa Analgesic polypeptide HC1,Yeast
  • 货号：
    CSB-YP458085HWE
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Heteractis crispa Analgesic polypeptide HC1,Yeast
  • 货号：
    CSB-EP458085HWE
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Heteractis crispa Analgesic polypeptide HC1,Yeast
  • 货号：
    CSB-EP458085HWE-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Heteractis crispa Analgesic polypeptide HC1,Yeast
  • 货号：
    CSB-BP458085HWE
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Heteractis crispa Analgesic polypeptide HC1,Yeast
  • 货号：
    CSB-MP458085HWE
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    ; TauPI-stichotoxin-Hcr2b; TauPI-SHTX-Hcr2b; Analgesic polypeptide HC1; APHC1
  • 种属：
    Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-78
  • 氨基酸序列
    GSICLEPK VVGPCTAYFR RFYFDSETGK CTVFIYGGCE GNGNNFETLR ACRAICRA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This protease inhibitor shows two different activities, it inhibits both the capsaicin receptor TRPV1 and serine proteases. It partially (max 50%) and reversibly inhibits capsaicin-induced response of TRPV1 (IC(50)=54 nM), a receptor of the pain pathway. The second activity is a weak inhibition of trypsin and chymotrypsin activity (Ki are 1 uM and 5 uM, respectively). In vivo, it shows antinociceptive and analgesic activitites. It significantly prolongs tail-flick latency and reduces capsaicin-induced acute pain. In vivo, unlike other TRPV1 antagonists whose activity is associated with hyperthermia, this protein has the remarkable feature of dropping core body temperature.
  • 亚细胞定位：
    Secreted. Nematocyst.
  • 蛋白家族：
    Venom Kunitz-type family, Sea anemone type 2 potassium channel toxin subfamily