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Recombinant Heteroscodra maculata Delta-theraphotoxin-Hm1a

In Stock
  • 货号:
    CSB-EP351577HGUa3
  • 规格:
    ¥2328
  • 图片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

产品详情

  • 纯度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    N/A
  • Uniprot No.:
  • 别名:
    ; Delta-theraphotoxin-Hm1a; Delta-TRTX-Hm1a; Heteroscodratoxin-1; HmTx1; Kappa-theraphotoxin-Hm1a; Kappa-TRTX-Hm1a
  • 种属:
    Heteroscodra maculata (Togo starburst tarantula)(Togo starburst baboon spider)
  • 蛋白长度:
    Full Length
  • 来源:
    E.coli
  • 分子量:
    21.5 kDa
  • 表达区域:
    1-35aa
  • 氨基酸序列
    ECRYLFGGCSSTSDCCKHLSCRSDWKYCAWDGTFS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签:
    N-terminal 6xHis-SUMO-tagged and C-terminal Myc-tagged
  • 产品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液:
    Tris-based buffer,50% glycerol
  • 储存条件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期:
    3-7 business days
  • 注意事项:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

产品评价

靶点详情

  • 功能:
    Gating-modifier toxin that potently inhibits inactivation of the mammalian Nav1.1/SCN1A sodium channel (EC(50)=38 nM). Also moderately inhibits inactivation of Nav1.2/SCN2A (EC(50)=236 nM) and Nav1.3/SCN3A (EC(50)=220 nM) when the channels are expressed in oocytes without the beta-1 auxiliary subunit. Does not inhibit inactivation of Nav1.2/SCN2A when the channel is coexpressed with the beta-1 auxiliary subunit. When tested on Nav1.1/SCN1A channel, it enhances peak current amplitude and potently delays channel inactivation in a dose-dependent ma...显示更多
  • 亚细胞定位:
    Secreted.
  • 蛋白家族:
    Huwentoxin-1 family, HaTx subfamily
  • 组织特异性:
    Expressed by the venom gland.