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  4. Recombinant Human 15 kDa selenoprotein (SEP15)

Recombinant Human 15 kDa selenoprotein (SEP15)

  • 货号：
    CSB-YP528908HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP528908HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP528908HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP528908HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP528908HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SELENOF
  • Uniprot No.：
  • 别名：
    15 kDa selenoprotein; SELENOF; Selenoprotein F; Sep15; SEP15_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    29-162
  • 氨基酸序列
    FG AEFSSEACRE LGFSSNLLCS SCDLLGQFNL LQLDPDCRGC CQEEAQFETK KLYAGAILEV CGUKLGRFPQ VQAFVRSDKP KLFRGLQIKY VRGSDPVLKL LDDNGNIAEE LSILKWNTDS VEEFLSEKLE RI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2.
  • 基因功能参考文献：
    1. The allelic and genotypic frequencies did not differ between rapid and nonrapid progressors; however, the presence of the AA genotype of the rs5859 polymorphism was associated with a shorter time of progression to AIDS compared with GG homozygotes (hazard ratio = 3.62, 95% CI = 1.55-8.43, p = 0.003). PMID: 27228552
    2. Genotype variation within the 3'-UTR of the SEP 15 gene showed no association with breast cancer risk or clinico-pathological parameters in Caucasian women. PMID: 26264612
    3. Results suggest that SEP15 plays important roles in the regulation of the G1 phase during the cell cycle as well as in cell motility of Chang liver cells offering a novel functional link between the cell cycle and cell motility. PMID: 25728752
    4. Concerning rs561104, the serum selenium concentration was higher in CC homozygotes (5.65 +/- 1.11 mug/dL) compared with T carriers (4.88 +/- 1.25 mug/dL, P = .044). PMID: 25249019
    5. Sep15 in Chang liver cells regulates the pathway that antagonizes RhoA/ROCK/MLC-dependent non-apoptotic bleb formation. PMID: 25529450
    6. This study provides evidence that SEP15 genetic variation may influence prostate cancer mortality PMID: 20424130
    7. Genetic and functional analysis of mammalian Sep15 selenoprotein. PMID: 11898406
    8. SEP15, encoding a 15-kDa selenium-containing protein was shown to be downregulated in approximately 60% of MM cell lines and tumor specimens. A SEP15 polymorphic variant, 1125A, resides in the SECIS recognition element PMID: 15107826
    9. It appears that those with the Sep15 1125 AA genotype may benefit most from a higher Se intake, whereas in those with the GG or GA genotype, a higher Se status may increase the risk for lung cancer. PMID: 18239845
    10. Studies in mouse show that Sep15 may have redox function. PMID: 12600282

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  • 亚细胞定位：
    Endoplasmic reticulum lumen. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.
  • 蛋白家族：
    Selenoprotein M/F family
  • 组织特异性：
    Higher levels in prostate and thyroid gland.
  • 数据库链接：

    HGNC: 17705

    OMIM: 606254

    KEGG: hsa:9403

    STRING: 9606.ENSP00000328729

    UniGene: Hs.362728