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  4. Recombinant Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD)

Recombinant Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD)

  • 中文名称：
    Recombinant Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(ACMSD),Yeast
  • 货号：
    CSB-YP851554HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(ACMSD),Yeast
  • 货号：
    CSB-EP851554HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(ACMSD),Yeast
  • 货号：
    CSB-EP851554HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(ACMSD),Yeast
  • 货号：
    CSB-BP851554HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(ACMSD),Yeast
  • 货号：
    CSB-MP851554HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ACMSD
  • Uniprot No.：
  • 别名：
    2 amino 3 carboxymuconate 6 semialdehyde decarboxylase; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; acmsd; ACMSD_HUMAN; Aminocarboxymuconate semialdehyde decarboxylase; Picolinate carboxylase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-336
  • 氨基酸序列
    MKIDIHSHIL PKEWPDLKKR FGYGGWVQLQ HHSKGEAKLL KDGKVFRVVR ENCWDPEVRI REMDQKGVTV QALSTVPVMF SYWAKPEDTL NLCQLLNNDL ASTVVSYPRR FVGLGTLPMQ APELAVKEME RCVKELGFPG VQIGTHVNEW DLNAQELFPV YAAAERLKCS LFVHPWDMQM DGRMAKYWLP WLVGMPAETT IAICSMIMGG VFEKFPKLKV CFAHGGGAFP FTVGRISHGF SMRPDLCAQD NPMNPKKYLG SFYTDALVHD PLSLKLLTDV IGKDKVILGT DYPFPLGELE PGKLIESMEE FDEETKNKLK AGNALAFLGL ERKQFE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
  • 基因功能参考文献：
    1. The minor C allele of the ACMSD SNP rs2121337 was more prevalent in suicide attempters. PMID: 27483383
    2. The crystal structures of the human enzyme in its native catalytically active state, a substrate analogue-bound form and a selected active site mutant form with one of the putative substrate binding residues altered, are reported. PMID: 25392945
    3. ACMSD is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism. ACMSD mutation contributes to the development of Familial cortical myoclonic tremor and epilepsy. PMID: 23955123
    4. Data report a crystal structure of human ACMSD in complex with the glycolytic intermediate 1,3-dihydroxyacetonephosphate (DHAP),suggesting a regulatory link between NAD synthesis and glycolysis. PMID: 19843166
    5. identification and expression of cDNA PMID: 12140278

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  • 蛋白家族：
    Metallo-dependent hydrolases superfamily, ACMSD family
  • 数据库链接：

    HGNC: 19288

    OMIM: 608889

    KEGG: hsa:130013

    STRING: 9606.ENSP00000348459

    UniGene: Hs.655728