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  4. Recombinant Human 60S ribosomal protein L10 (RPL10)

Recombinant Human 60S ribosomal protein L10 (RPL10)

  • 货号：
    CSB-YP020106HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP020106HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP020106HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP020106HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP020106HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RPL10
  • Uniprot No.：
  • 别名：
    RPL10; DXS648E; QM; 60S ribosomal protein L10; Laminin receptor homolog; Large ribosomal subunit protein uL16; Protein QM; Ribosomal protein L10; Tumor suppressor QM
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-214
  • 氨基酸序列
    GRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLCG HMVSDEYEQL SSEALEAARI CANKYMVKSC GKDGFHIRVR LHPFHVIRIN KMLSCAGADR LQTGMRGAFG KPQGTVARVH IGQVIMSIRT KLQNKEHVIE ALRRAKFKFP GRQKIHISKK WGFTKFNADE FEDMVAEKRL IPDGCGVKYI PNRGPLDKWR ALHS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
  • 基因功能参考文献：
    1. The regulation of reactive oxygen species level by mitochondrial RPL10 is one of the major extra-ribosomal functions in pancreatic cancer cells, which could be used as an indicator for the tumorigenesis of pancreatic cancer. PMID: 30172100
    2. there are 7 mutations in RPL10 in 344 patients, or a mutation frequency of 2% PMID: 28428269
    3. A rare de novo mutation K78E is associated with severe syndromic intellectual disability and epilepsy. PMID: 29066376
    4. Mitochondrial Ribosomal Protein L10 regulates cyclin B1/Cdk1 (cyclin-dependent kinase 1) activity and mitochondrial protein synthesis in mammalian cells PMID: 27726420
    5. Our results expand the mutational and clinical spectrum of RPL10 identifying a new genetic cause of SED and highlight the emerging role of ribosomal proteins in the pathogenesis of neurodevelopmental disorders. PMID: 26290468
    6. report confirms the implication of RPL10 mutations in neurodevelopmental disorders and extends the associated clinical spectrum from autism to syndromic intellectual disability PMID: 25846674
    7. A mutation within the conserved N-terminal end of RPL10, a protein in close proximity to the peptidyl transferase active site of the 60S ribosomal subunit, causes severe defects in brain formation and function. PMID: 25316788
    8. Mutations affect the ribosomal proteins RPL5 and RPL10 in 12 of 122 (9.8%) pediatric T-cell acute lymphoblastic leukemias, with recurrent alterations of Arg98 in RPL10. PMID: 23263491
    9. mutation analysis of RPL10 in German patients with autism spectrum disorder PMID: 21567917
    10. Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism PMID: 16940977
    11. QM binds to c-yes at the SH3 domain in tumor cell lines PMID: 12138090
    12. Reduction of QM protein expression correlates with tumor grade in prostatic adenocarcinoma PMID: 16331298
    13. Xq28 (QM gene) may be involved in ovary failure. PMID: 17566674
    14. A hexagonal crystal of L10CD was obtained by the sitting-drop vapour-diffusion method. The L10CD crystal diffracted to 2.5 A resolution and belongs to space group P3(1)21 or P3(2)21. PMID: 18007048
    15. Characteristic interactions among Arg90-Trp171-Arg139 guide the C-terminal part outside of the central fold PMID: 18258260
    16. Our results suggest that RPL10 has no major effect on the susceptibility to autism spectrum disorders PMID: 19166581

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  • 相关疾病：
    Autism, X-linked 5 (AUTSX5); Mental retardation, X-linked, syndromic, 35 (MRXS35)
  • 蛋白家族：
    Universal ribosomal protein uL16 family
  • 数据库链接：

    HGNC: 10298

    OMIM: 300847

    KEGG: hsa:6134

    STRING: 9606.ENSP00000341730

    UniGene: Hs.534404