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  4. Recombinant Human ADP-ribosylation factor-like protein 11 (ARL11)

Recombinant Human ADP-ribosylation factor-like protein 11 (ARL11)

  • 中文名称：
    Recombinant Human ADP-ribosylation factor-like protein 11(ARL11),Yeast
  • 货号：
    CSB-YP850249HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human ADP-ribosylation factor-like protein 11(ARL11),Yeast
  • 货号：
    CSB-EP850249HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human ADP-ribosylation factor-like protein 11(ARL11),Yeast
  • 货号：
    CSB-EP850249HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human ADP-ribosylation factor-like protein 11(ARL11),Yeast
  • 货号：
    CSB-BP850249HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human ADP-ribosylation factor-like protein 11(ARL11),Yeast
  • 货号：
    CSB-MP850249HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ARL11
  • Uniprot No.：
  • 别名：
    ADP ribosylation factor like 11; ADP ribosylation factor like protein 11; ADP ribosylation factor like tumor suppressor protein 1; ADP-ribosylation factor-like protein 11; ADP-ribosylation factor-like tumor suppressor protein 1; ARL11; ARL11_HUMAN; ARLTS1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-196
  • 氨基酸序列
    GSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP LKAPGHVSLT LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA AELTEVLNDP NMAGVPFLVL ANKQEAPDAL PLLKIRNRLS LERFQDHCWE LRGCSALTGE GLPEALQSLW SLLKSRSCMC LQARAHGAER GDSKRS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in apoptosis. May act as a tumor suppressor.
  • 基因功能参考文献：
    1. ARLTS1 gene mutations can be considered as a potential predisposing factor in familial hematological malignancies PMID: 27866680
    2. A statistically significant (p = 0.0037) decrease of ARLTS1 expression in prostate cancer cases was detected. PMID: 23940804
    3. the important role of ARLTS1 Cys148Arg variant as a contributor in prostate cancer predisposition PMID: 22028916
    4. A significantly increased risk was observed for young ovarian cancer patients with ARLTS1 Cys148Arg variant. PMID: 20067102
    5. The role of the allelic variants in ARLTS1, RAD51 and MDM2 acting in the tumor suppressor, DNA repair and p53 pathways as risk factors for familial breast cancer in 147 patients displaying characteristics of familial disease, was investigated. PMID: 20358297
    6. A novel tumor suppressor gene [ARLTS1 (ADP-ribosylation factor-like tumor suppressor gene 1)]is found to be altered in human carcinogenesis. It is located in Chromosome 13q14.3. PMID: 18375053
    7. A genetic variant of ARLTS1 predisposes patients to familial cancer. PMID: 15843669
    8. the G446A in ARLTS1 gene is probably not associated with an increased risk of sporadic breast cancer, prostate cancer, melanoma, thyroid papillary cancer or laryngeal cancer PMID: 16570116
    9. The study does not support the postulate that variants of ARLTS1 influence the risk of chronic lymphocytic leukemia(CLL). PMID: 16581122
    10. While ARLTS1 Trp149Stop did not influence melanoma risk (OR = 0.83, 95% CI = 0.37-1.88, p = 0.65), Cys148Arg revealed a statistically significant association with an increased risk for heterozygous carriers (OR = 1.43, 95% CI = 1.05-1.95, p = 0.02) PMID: 16646072
    11. we found no association of ARLTS1 polymorphisms and risk for familial chronic lymphocytic leukaemia PMID: 17391501
    12. Cysteine148Arginine variant is associated with a moderately increased risk of colorectal cancer, both in sporadic and familial cases. PMID: 17449901
    13. 650 transcripts expressed after restoration of ARLTS1 expression were identified in A549 cells, suggesting that pathways involved in cell survival, proliferation, signaling, and development mediate the effects of wild-type ARLTS1 in lung cancer. PMID: 17699778
    14. ARLTS1 germline variants are not associated with breast, prostate, and colorectal cancer PMID: 18337727
    15. Data show a significantly increased risk of familial OC for ARLTS1 Cys148Arg variant, which indicate that ARLTS1 may play a role in familial ovarian cancer. PMID: 19509554

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  • 相关疾病：
    Leukemia, chronic lymphocytic (CLL)
  • 蛋白家族：
    Small GTPase superfamily, Arf family
  • 组织特异性：
    Expressed in lung and leukocytes.
  • 数据库链接：

    HGNC: 24046

    OMIM: 151400

    KEGG: hsa:115761

    STRING: 9606.ENSP00000282026

    UniGene: Hs.558599