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  4. Recombinant Human AMSH-like protease (STAMBPL1)

Recombinant Human AMSH-like protease (STAMBPL1)

  • 中文名称：
    人STAMBPL1重组蛋白
  • 货号：
    CSB-YP853417HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人STAMBPL1重组蛋白
  • 货号：
    CSB-EP853417HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人STAMBPL1重组蛋白
  • 货号：
    CSB-EP853417HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人STAMBPL1重组蛋白
  • 货号：
    CSB-BP853417HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人STAMBPL1重组蛋白
  • 货号：
    CSB-MP853417HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    STAMBPL1
  • Uniprot No.：
  • 别名：
    ALMalpha; AMSH FP; AMSH LP; AMSH-like protease; AMSH-LP; AMSHFP; AMSHLP; Associated molecule with the SH3 domain of STAM (AMSH) like protein; FLJ31524; OTTHUMP00000020055; STALP_HUMAN; STAM binding protein like 1; STAM-binding protein-like 1; STAMBPL1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-436
  • 氨基酸序列
    MDQPFTVNSL KKLAAMPDHT DVSLSPEERV RALSKLGCNI TISEDITPRR YFRSGVEMER MASVYLEEGN LENAFVLYNK FITLFVEKLP NHRDYQQCAV PEKQDIMKKL KEIAFPRTDE LKNDLLKKYN VEYQEYLQSK NKYKAEILKK LEHQRLIEAE RKRIAQMRQQ QLESEQFLFF EDQLKKQELA RGQMRSQQTS GLSEQIDGSA LSCFSTHQNN SLLNVFADQP NKSDATNYAS HSPPVNRALT PAATLSAVQN LVVEGLRCVV LPEDLCHKFL QLAESNTVRG IETCGILCGK LTHNEFTITH VIVPKQSAGP DYCDMENVEE LFNVQDQHDL LTLGWIHTHP TQTAFLSSVD LHTHCSYQLM LPEAIAIVCS PKHKDTGIFR LTNAGMLEVS ACKKKGFHPH TKEPRLFSIC KHVLVKDIKI IVLDLR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.
  • 基因功能参考文献：
    1. Catalytic Mechanism of Human AMSH-LP Domain Deubiquitinating Enzymes PMID: 26256234
    2. Cellular STAMBPL1 is a positive regulator of human T-cell leukemia virus type 1 Tax-mediated NF-kappaB signaling. PMID: 22258247
    3. Data show that associated molecule with the SH3 domain of STAM-like protein (AMSH-LP), unlike AMSH, fails to bind to the SH3 domains of STAM1 (signal transducing adaptor molecule 1) and Grb2. PMID: 12810066
    4. AMSH and AMSH-LP are anchored on the early endosomal membrane via interaction with the clathrin coat PMID: 16716190
    5. AMSH redirects CaR from slow recycling to down-regulation, reducing CaR expression and decreasing PTHrP secretion. PMID: 17426287

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  • 蛋白家族：
    Peptidase M67C family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 24105

    OMIM: 612352

    KEGG: hsa:57559

    STRING: 9606.ENSP00000360992

    UniGene: Hs.16229