Recombinant Human Alcohol dehydrogenase 1C (ADH1C)

1. The influence of ADH3 genetic polymorphisms on the status of liver function showed significant difference according to GGT measurement, but the same cannot be said on the other two values measuring SGOT and SGPT. PMID: 28239076
2. Expression of xylanase under the regulation of ADH3, AOX1 and GAP was compared.The highest enzyme production was obtained with AOX1 culture at shake-flask level.The PADH3 cultures were more productive than AOX1 and GAP at fermentor scale PMID: 26835836
3. The ADH1C *1/*2 polymorphism is likely associated with pancreatitis risk. PMID: 26634490
4. the combination of genotypes ADH2 * 2, CYP2E1 * 1 combined with genotype homozygous ALDH2 * 1 found in this study could be leading to the population to a potential risk to alcoholism. The role of ADH3 was not indicated. PMID: 26848198
5. Thus these findings suggest that the three variants of ADH1C, MnSOD and GSTM1 can be used to identify individuals who are at high risk to develop ALD and may be helpful in proper management of Indian alcoholics PMID: 26937962
6. Results show that mutation of this protein confers associated protection against alcohol dependence. However these associations were not completely independent PMID: 24735490
7. Among the Inuit in Greenland, ADH1C SNPs play a role in shaping their alcohol drinking patterns. PMID: 25311581
8. findings suggest that ADH1C*2 is associated with alcohol dependence in the Turkish population displaying a dominant inheritance model. ADH1C*2 allele may contribute to the variance in heritability of alcohol dependence. PMID: 25372623
9. Young male East Indians with at least one ADH1C*2 allele feel less effects of alcohol, including nausea. PMID: 25208201
10. a positive association between inactive ADH1C G allele and alcohol consumption regarding gastric cancer risk was found, opposite to that found in previous studies PMID: 25524923
11. Decreased expression of ADH1C gene is associated with disease progression. PMID: 24599561
12. Alcohol dehydrogenase (ADH)1B and ADH1C are jointly associated with alcohol use disorders, but not consumption. PMID: 23895337
13. additional support for the association of SNP rs1614972 in ADH1C with alcohol dependence PMID: 23516558
14. ADH1C polymorphism is not associated with childhood acute leukemia and maternal caffeinated beverage consumption during pregnancy. PMID: 23404349
15. study failed to find any link between the ADH1C genotype and the cardioprotective effects of alcohol PMID: 23321361
16. did not observe association of ADH1C polymorphism with esophageal cancer PMID: 22930414
17. The frequency of ALDH2*2 and ADH3*1 alleles in risk drinkers was lower than that in safe drinkers in a male Tibetan population. PMID: 22279680
18. No associations between alcohol dependence and polymorphisms in ADH1C were found in Mexican and Native Americans PMID: 22931071
19. Findings suggest that a significantly higher presence of ADH1C*2 allele is associated with alcohol dependence in a Turkish population. PMID: 22414625
20. This meta-analysis suggests that ADH1C polymorphism may not be associated with breast cancer development in Caucasians. PMID: 22353233
21. ADH1C Ile350Val polymorphism may contribute to cancer risk among Africans and Asians. PMID: 22675424
22. findings support that ADH1C Ile may lower the risk of alcohol dependence and alcohol abuse as well as alcohol-related cirrhosis in pooled populations, with the strongest and most consistent effects in Asians PMID: 22476623
23. in a study of alcohol metabolic genotypes in drunk drivers, the rs698 ADH1C and rs671 ALDH2 polymorphisms were not associated with MCV PMID: 21917409
24. No profound connection between alcohol dependence and ADH1C Ile350Val gene polymorphism was detected. PMID: 22325912
25. This study shows differences in the distribution of the frequency of allele ADH1C*1 between the Basque Country and Moroccan populations, and a new allele not described to date. PMID: 21303386
26. This study suggested that the ADH1C Sspl polymorphism could play a significant role in the etiology of oral cancer. PMID: 21705789
27. The presence of ADH3 in normal lung development (A549 cell line), & the capacity to convert retinol to retinoic acid, indicates that fetal human lung has the ability to regulate the supply of vitamin A from the pseudoglandular stage. PMID: 21482329
28. the ADH1C*2/*2 genotype was associated with a 42% increase in risk of colorectal cancer when compared with the ADH1C*1/*1 genotype. PMID: 21163612
29. Polymorphisms in ADH1C is associated with pancreatic cancer. PMID: 19068087
30. The increased risk of oral clefts was evident only in mothers or children who carried the ADH1C haplotype associated with reduced alcohol metabolism. PMID: 20810466
31. These findings suggest that a lower presence of ADH1C*1 allele is associated with squamous cell carcinoma of the head and neck PMID: 20448861
32. Among variant allele carriers of ADH1C Arg(272)Gln, alcohol intake increased the risk of breast cancer with 14% (95% CI: 1.04-1.24) per 10g alcohol/day. PMID: 20350778
33. Results suggest that the ADH1C allele modifies the carcinogenic dose response for alcohol in the upper aerodigestive tract, giving rise to a gene-environment interaction. PMID: 20437850
34. ADH1C polymorphisms were not significantly associated with pancreatic cancer risk. PMID: 19812523
35. Besides the identification of new genetic factors related to alcohol biodisposition relevant to whites, this study provides unambiguous identification of diplotypes related to variability in alcohol biodisposition. PMID: 20101753
36. ADH1C gene polymorphisms are associated with upper aerodigestive tract cancers. PMID: 19861527
37. Report associations between genetic variation of alcohol dehydrogenase type 1C (ADH1C), alcohol consumption, and metabolic cardiovascular risk factors. PMID: 19447389
38. A new coding variant has been identified at codon 351 of ADH1C, an allele found in most Native American populations studied, with allele frequencies of the new ADH1C*351Thr allele as high as 26%. PMID: 12500098
39. Results suggest that alcohol dehydrogenase 3 catalysed S-nitrosoglutathione reduction is of physiological relevance in the metabolism of NO in humans. PMID: 12631283
40. There is no significant interaction between alcohol consumption and ADH3 genotype. PMID: 12658118
41. adh3 gene is implicated in alcoholism incidence among African Americans PMID: 12713190
42. gastric ADH3 may highly effectively contribute to the first-pass metabolism at 0.5-3 M ethanol, an attainable range in the gastric lumen during alcohol consumption PMID: 12782305
43. mutations in genes encoding ADH1C (G78Stop) as genetic risk factors for Parkinson disease . PMID: 15642852
44. ADH1C polymorphisms in the cis-acting elements affect transcription. PMID: 15643610
45. a slower alcohol clearance rate is associated with the ADH3 y2 allele [letter] PMID: 15842377
46. mean corpuscular volume values were not associated with genotype polymorphisms of ADH1C PMID: 15897724
47. No association has been revealed for the alcohol metabolism-related ADH3 genotype and Korean patients with alcoholism compared to Korean control subjects without alcoholism. PMID: 15902904
48. Conversely, in both genders, no differences were found between ADH3 genotypes regarding all cardiovascular risk factors studied and carotid intima-media thickness. PMID: 15941567
49. ADH1C genotype modifies the association between alcohol consumption and HDL levels among men and postmenopausal women not using postmenopausal hormones who drink moderately PMID: 16051248
50. Alcohol dehydrogenase 3 null genotypes did not modify the risk of HCC due to alcohol intake. PMID: 16132793

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HGNC: 251

OMIM: 103730

KEGG: hsa:126

UniGene: Hs.654537