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  4. Recombinant Human Aldo-keto reductase family 1 member B15 (AKR1B15)

Recombinant Human Aldo-keto reductase family 1 member B15 (AKR1B15)

  • 中文名称：
    Recombinant Human Aldo-keto reductase family 1 member B15(AKR1B15),Yeast
  • 货号：
    CSB-YP513924HU(F2)
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Aldo-keto reductase family 1 member B15(AKR1B15),Yeast
  • 货号：
    CSB-EP513924HU(F2)
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Aldo-keto reductase family 1 member B15(AKR1B15),Yeast
  • 货号：
    CSB-EP513924HU(F2)-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Aldo-keto reductase family 1 member B15(AKR1B15),Yeast
  • 货号：
    CSB-BP513924HU(F2)
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Aldo-keto reductase family 1 member B15(AKR1B15),Yeast
  • 货号：
    CSB-MP513924HU(F2)
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    AKR1B15
  • Uniprot No.：
  • 别名：
    AKR1B15Aldo-keto reductase family 1 member B15; EC 1.1.1.-; EC 1.1.1.300; EC 1.1.1.54; Estradiol 17-beta-dehydrogenase AKR1B15; Farnesol dehydrogenase; EC 1.1.1.216; Testosterone 17beta-dehydrogenase; EC 1.1.1.64
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Isoform 2
  • 表达区域：
    1-344
  • 氨基酸序列
    MVLQMEPQVN STNNFHQGPL DQPVGPLTGL KSSLLKDTTS AGPLLRPYPA SLLGKVKEAV KVAIDAEYRH IDCAYFYENQ HEVGEAIQEK IQEKAVMRED LFIVSKVWPT FFERPLVRKA FEKTLKDLKL SYLDVYLIHW PQGFKTGDDF FPKDDKGNMI SGKGTFLDAW EAMEELVDEG LVKALGVSNF NHFQIERLLN KPGLKYKPVT NQVECHPYLT QEKLIQYCHS KGITVTAYSP LGSPDRPWAK PEDPSLLEDP KIKEIAAKHK KTTAQVLIRF HIQRNVTVIP KSMTPAHIVE NIQVFDFKLS DEEMATILSF NRNWRAFDFK EFSHLEDFPF DAEY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds. In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal. May play a physiological role in retinoid metabolism.; No oxidoreductase activity observed with the tested substrates.
  • 基因功能参考文献：
    1. Amino acid substitutions clustered in loops A and C result in a smaller more hydrophobic and more rigid active site in AKR1B15 compared with the AKR1B10 pocket, consistent with distinct substrate specificity and narrower inhibitor selectivity for AKR1B15. PMID: 26222439
    2. AKR1B15.2 localizes to the cytosol and displays no enzymatic activity with the substrates tested. PMID: 25577493
    3. human sperm possess an aldo-keto reductase on their membrane surface and are thus enzymatically protected against reactive aldehyde species both in the male and female reproductive tract PMID: 22970857
    4. Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients PMID: 22277967
    5. AKR1B15 and Akr1b16 genes are expressed as functional proteins in human and murine tissues PMID: 21276782
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624

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  • 亚细胞定位：
    [Isoform 1]: Mitochondrion.; [Isoform 2]: Cytoplasm, cytosol.
  • 蛋白家族：
    Aldo/keto reductase family
  • 组织特异性：
    Widely expressed. Expressed at highest levels in steroid-sensitive tissues, such as placenta, testis and adipose tissue.
  • 数据库链接：

    HGNC: 37281

    OMIM: 616336

    KEGG: hsa:441282

    STRING: 9606.ENSP00000389289

    UniGene: Hs.729418