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  4. Recombinant Human Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT1), partial

Recombinant Human Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT1), partial

  • 中文名称：
    人MGAT1重组蛋白
  • 货号：
    CSB-YP013773HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MGAT1重组蛋白
  • 货号：
    CSB-EP013773HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MGAT1重组蛋白
  • 货号：
    CSB-EP013773HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MGAT1重组蛋白
  • 货号：
    CSB-BP013773HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MGAT1重组蛋白
  • 货号：
    CSB-MP013773HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MGAT1
  • Uniprot No.：
  • 别名：
    MGAT1; GGNT1; GLCT1; GLYT1; MGAT; Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I; GNT-I; GlcNAc-T I
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
  • 基因功能参考文献：
    1. In this study we showed that the activation of Wnt/beta-catenin pathway culminates in the upregulation of MGAT1 enzyme both at transcriptional and post-transcriptional levels. We also showed that overexpression of the beta-catenin gene (CTNNB1) increased the promoter activity of MGAT1. PMID: 29310626
    2. The presence of the rs4285184 polymorphism of the MGAT1 gene increased the risk for developing body fat associated with obesity in the Mexican population. PMID: 27871764
    3. MGAT1 is downregulated in peripheral blood mononuclear cells of galactosaemia patients. PMID: 26733289
    4. The s show here that the luminal domain of GnT1IP-L contains its MGAT1 inhibitory activity. PMID: 26371870
    5. UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats). PMID: 25944901
    6. The IL2RA and IL7RA variants had univariate association in MS and T1D, whereas the MGAT1 and CTLA-4 variants associated with only MS or T1D, respectively. PMID: 24572742
    7. analysis of suppression of cancer progression by MGAT1 shRNA knockdown PMID: 22957033
    8. Genetic variants downstream MGAT1 seem to influence susceptibility to obesity. Moreover, these genetic variants affect the levels of serum unsaturated fatty acids and Delta desaturase indices, variables previously shown to correlate with obesity. PMID: 21304485
    9. Activity of HuGnTI in plants is limited by a combination of reduced protein stability, alternative protein targeting and possibly to some extend to lower enzymatic performance of the catalytic domain in the plant biochemical environment. PMID: 19826906
    10. The analysis enabled us to identify a new candidate gene, MGAT1, associated with weight in women. PMID: 19851299
    11. Findings indicated that cysteine 121 has a structural role in maintaining active site geometry of hGnT1, rather than a catalytic role, and illustrates for the first time the potential utility of E. coli as an expression system for hGnT1. PMID: 17716624

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Glycosyltransferase 13 family
  • 数据库链接：

    HGNC: 7044

    OMIM: 160995

    KEGG: hsa:4245

    STRING: 9606.ENSP00000311888

    UniGene: Hs.519818