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  4. Recombinant Human Aminoglycoside phosphotransferase domain-containing protein 1 (AGPHD1)

Recombinant Human Aminoglycoside phosphotransferase domain-containing protein 1 (AGPHD1)

  • 中文名称：
    人HYKK重组蛋白
  • 货号：
    CSB-YP383397HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HYKK重组蛋白
  • 货号：
    CSB-EP383397HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HYKK重组蛋白
  • 货号：
    CSB-EP383397HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HYKK重组蛋白
  • 货号：
    CSB-BP383397HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HYKK重组蛋白
  • 货号：
    CSB-MP383397HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HYKK
  • Uniprot No.：
  • 别名：
    5-hydroxy-L-lysine kinase; AGPD1_HUMAN; Agphd1; Aminoglycoside phosphotransferase domain containing ; Aminoglycoside phosphotransferase domain-containing protein 1; C630028N24Rik; HYKK; OTTMUSP00000025874; RGD1308677
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-373
  • 氨基酸序列
    MSSGNYQQSE ALSKPTFSEE QASALVESVF GLKVSKVRPL PSYDDQNFHV YVSKTKDGPT EYVLKISNTK ASKNPDLIEV QNHIIMFLKA AGFPTASVCH TKGDNTASLV SVDSGSEIKS YLVRLLTYLP GRPIAELPVS PQLLYEIGKL AAKLDKTLQR FHHPKLSSLH RENFIWNLKN VPLLEKYLYA LGQNRNREIV EHVIHLFKEE VMTKLSHFRE CINHGDLNDH NILIESSKSA SGNAEYQVSG ILDFGDMSYG YYVFEVAITI MYMMIESKSP IQVGGHVLAG FESITPLTAV EKGALFLLVC SRFCQSLVMA AYSCQLYPEN KDYLMVTAKT GWKHLQQMFD MGQKAVEEIW FETAKSYESG ISM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
  • 基因功能参考文献：
    1. CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers. PMID: 27072204
    2. The association between AGPHD1 single nucleotide polymorphism rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that AGPHD1 single nucleotide polymorphism rs8034191 is a risk factor for lung cancer. PMID: 25854352
    3. The variant rs8034191 in the AGPHD1 gene may not modify the genetic risk of lung cancer in Asian populations. PMID: 25074529
    4. Women with the variant AA genotype of CHRNA5 rs16969968 or variant CC genotype of LOC123688 rs8034191 were at significantly increased risk of heavy smoking. PMID: 21810735
    5. AGPHD1 gene rs8034191-T allele might be a risk-conferring factor for the development of lung cancer in Caucasians, but not in East-Asians. PMID: 22701590

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Aminoglycoside phosphotransferase family
  • 数据库链接：

    HGNC: 34403

    OMIM: 614681

    KEGG: hsa:123688

    STRING: 9606.ENSP00000373640

    UniGene: Hs.307962