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  4. Recombinant Human Anthrax toxin receptor 1 (ANTXR1), partial

Recombinant Human Anthrax toxin receptor 1 (ANTXR1), partial

  • 货号：
    CSB-EP001832HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001832HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001832HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001832HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Anthrax toxin receptor 1; ANTR1_HUMAN; Antxr1; ATR; Tumor endothelial marker 8
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 分子量：
    34.4kDa
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.; (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis.
  • 基因功能参考文献：
    1. Silencing TEM8 may inhibit proliferation of XWLC05 lung cancer cells, promote cell apoptosis, arrest the cell cycle at G1 phase and decrease the migration and invasive ability. PMID: 29115620
    2. Novel targets ANTXR1 and RSPO2 were confirmed to be suppressed by miR-493 directly. PMID: 28651234
    3. These studies identify ANTXR1, a class of receptor that is shared by a mammalian virus and a bacterial toxin, as the cellular receptor for Seneca Valley virus. PMID: 28650343
    4. expression does not affect cytotoxicity to anthrax toxin PMID: 27170489
    5. Findings suggest that down-regulation of tumor endothelial marker 8 play an important role in the inhibition of tumorigenesis and development of osteosarcoma. PMID: 26996335
    6. TEM8 may be differentially expressed between wound types and loss of this molecule impacts HaCaT growth and migration, potentially implicating this molecule as a factor involved in successful progression of wound healing. PMID: 26677171
    7. In the absence of any N-linked glycans, TEM8 fails to fold correctly and is recognized by the ER quality control machinery. PMID: 25781883
    8. These studies expand the allelic spectrum in this rare condition and potentially provide insight into the role of ANTXR1 in the regulation of the extracellular matrix. PMID: 25045128
    9. TEM8-targeted siRNAs also offered significant protection against lethal toxin in human macrophage-like cells. PMID: 24742682
    10. ANTXR2 is expressed by human uterine smooth muscle cell and appears important for normal human uterine smooth muscle cell viability, migration and contractility. PMID: 24060446
    11. High ANTXR1 accelerates breast tumor growth and lung metastasis. PMID: 23832666
    12. There is an attenuation of ANTXR1 expression post-infection which may be a protective mechanism that has evolved to prevent reinfection. PMID: 23607659
    13. Mutations affecting ANTXR1 function are responsible for GAPO syndrome's characteristic generalized defect in extracellular-matrix homeostasis. PMID: 23602711
    14. Two new splice variants, one encoding a membrane-bound form of the receptor and the other secreted, which we have designated V4 and V5 (the latter being the only variant expressed in the prostate). PMID: 22912819
    15. An acidic region in the cytosolic tail of ANTXR1 decreases actin association, sending a signal that prevents binding of ANTXR1 to the protective antigen and providing evidence that cytoskeletal dynamics regulate ANTXR1 function. PMID: 22303962
    16. Disruption of Tem8 results in impaired growth of human tumor xenografts of diverse origin including melanoma, breast, colon, and lung cancer. PMID: 22340594
    17. The copy number of CEA and TEM-8 mRNA, as detected by a real-time quantitative PCR, appears to be a promising marker for evaluating the risk of tumor spread. PMID: 21573768
    18. postulate that the developmentally controlled expression of TEM8 modulates endothelial cell response to canonical Wnt signaling to regulate vessel patterning and density PMID: 21829615
    19. TEM8.1 expression in breast cancer cells confers a more aggressive, proangiogenic phenotype. PMID: 22085271
    20. TEM8 was expressed at a higher level in the stroma adjacent to the triple-negative breast cancer in all cases, with focal immunoreactive areas within the tumor. PMID: 21965755
    21. studies reveal that TEM8 exists in different forms at the cell surface, a structure dependent on interactions with components of the actin cytoskeleton PMID: 21129411
    22. Data show that the two different PA oligomers are equally stabilized by ANTXR interactions. PMID: 21079738
    23. Results describe the expression, purification and crystallization of human anthrax toxin receptor 1 vWA domain to 1.8 A resolution from a single crystal. PMID: 21206026
    24. the crystal structure of the TEM8 extracellular vWA domain at 1.7 A resolution. PMID: 20585457
    25. actin was also found to be essential for efficient heptamerization of anthrax toxin PA, but only when bound to one of its 2 receptors, TEM8 PMID: 20221438
    26. Here we describe the cloning of the human PA receptor using a genetic complementation approach PMID: 11700562
    27. This is the first demonstration that the ATR/TEM8 protein is highly expressed in epithelial cells, suggesting that the ATR/TEM8 expression pattern is highly relevant for understanding the pathogenesis of anthrax infection. PMID: 15689409
    28. results indicate that TEM8 plays a positive role in endothelial cell activities related to angiogenesis PMID: 15777794
    29. These results suggest that the TEM-8 vW and transmembrane domains may play an important biological role in TEM-8 related tubule formation. PMID: 15993844
    30. because protective antigen binds to CMG2 with much higher affinity than it does to TEM8, a lower pH is needed to attenuate CMG2 binding to allow pore formation; toxin can form pores at different points in the endocytic pathway PMID: 16141341
    31. Data show that cells expressing palmitoylation-defective mutant receptors are less sensitive to anthrax toxin due to a lower number of surface receptors as well as premature internalization of protective antigen without a requirement for heptamerization. PMID: 16401723
    32. TEM8 is a new adhesion molecule linking collagen I or PA to the actin cytoskeleton PMID: 16762926
    33. TEM8 expression levels in DC-based therapeutic vaccines would allow the selection of a subgroup of patients who are most likely to benefit from therapeutic vaccination. PMID: 19440709
    34. ANTXR1 does not use an adaptor to bind the cytoskeleton. This peptide orders actin filaments into arrays, demonstrating an actin bundling activity that is novel for a membrane protein PMID: 19817382
    35. ATR/TEM8 protein is highly expressed in epithelial cells, which represent the primary location for bacterial invasion. PMID: 15689409

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  • 相关疾病：
    Hemangioma, capillary infantile (HCI); GAPO syndrome (GAPO)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    ATR family
  • 组织特异性：
    Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
  • 数据库链接：

    HGNC: 21014

    OMIM: 230740

    KEGG: hsa:84168

    STRING: 9606.ENSP00000301945

    UniGene: Hs.165859