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  4. Recombinant Human B2 bradykinin receptor (BDKRB2), partial

Recombinant Human B2 bradykinin receptor (BDKRB2), partial

  • 货号：
    CSB-YP002652HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002652HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002652HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002652HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002652HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    BDKRB2; BKR2; B2 bradykinin receptor; B2R; BK-2 receptor
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  • 基因功能参考文献：
    1. Study results indicated that the bradykinin B2 receptor-mediated pathway is involved in the cPLA2-related inflammatory response from the PKC pathway in traumatic brain injury. PMID: 29894755
    2. The most characteristic signaling pathways for B2R and D2R, dependent on intracellular Ca(2+) and cAMP concentration, respectively, were analyzed in cells presenting similar endogenous expression of B2R and D2R.The evidence of B2R-D2R dimerization may open new perspectives in the modulation of diverse cellular functions which depend on their activation. PMID: 28757212
    3. These results indicate that KOR can form a heterodimer with B2R and this leads to increased protein kinase A activity by the CREB signaling pathway, leading to a significant increase in cell proliferation. PMID: 28069442
    4. Study demonstrated the ability of long-chain polyunsaturated fatty acids to act as agonist to the B2R at nanomolar concentrations and to induce receptor conformational changes. PMID: 23826374
    5. Data suggest that N-myc (and STAT) interactor (NMI) could improve its downstream target bradykinin B2 receptor (BDKRB2) expression to induce extracellular signal-regulated kinases (ERK) 1/2 activation, and thereby further evoke malignant progression of hepatocellular carcinoma (HCC). PMID: 28077802
    6. BDKRB2 +9/-9 bp polymorphisms affected the gene expression and nitric oxide production, which were associated with radiographic severity of osteoarthritis, suggesting that the BDKRB2 +9/ -9 bp polymorphisms may act as a genetic modulator of osteoarthritis, and play an essential role in inflammatory process in osteoarthritis. PMID: 26764266
    7. Review/Meta-analysis: suggest bradykinin B2 receptor -58C allele and -58CC genotype increase the risk of hypertension in Asians and African-Americans. Inversely, -58TT genotype decreases the risk of hypertension in Asians and African-Americans. PMID: 27007662
    8. s found significant interactions among PRKCA, NOS3 and BDKRB2 genotypes associated with enalapril responses. PMID: 27696692
    9. Bronchial B2R expression is constitutively elevated in allergic asthma and is further increased after allergen exposure together with NF-kB expression. PMID: 26588817
    10. Report the presence of nuclear B2R in the utero-placental unit and reduced abundance of nuclear B2R in extravillous trophoblast in preeclampsia. PMID: 26955769
    11. Data provide evidence that the BDKRB2 +9/-9 polymorphisms influence pro-inflammatory cytokine levels in knee osteoarthritis by altering TLR-2 expression. PMID: 26982743
    12. These results suggest that the response to long-term exercise training could be modulated by the BDKRB2 gene -9/+9 polymorphism in male athletes. In well-trained swimmers, BDKRB2 gene variation was not found to be an independent determinant of swimming performance. PMID: 26907838
    13. Significant association between the -58T/C polymorphism and the increased risk of Hypertension was found in Northern Han Chinese population. PMID: 26362411
    14. Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways. PMID: 26360782
    15. Bradykinin receptor B2 (B2R) genetic variation may affect thirst because of effects bradykinin activity. PMID: 25641172
    16. These results indicate that B2R couples with P2Y2R and that these G-protein-coupled receptors act together to fine-tune cellular responsiveness. PMID: 25713410
    17. The nasal mucosa specimens from chronic rhinosinusitis patients expressed relatively higher B2R and slightly higher kininogen (KNG)/BK and B1R. PMID: 25970620
    18. A cross-talk was found between bradykinin B2 receptor and cytokines in retinal pigment epithelium. PMID: 26235941
    19. no association between the -9/+9 polymorphism and elite athletic status PMID: 25078958
    20. Genetic variation was observed in obese patients with hypertension, obese patients' total cholesterol levels varied by genotype, and waist circumference and blood pressure were elevated in the non-obese having a C/C genotype compared to T/C and T/T. PMID: 25529519
    21. Bradykinin receptor B2-VNTR length polymorphism was not associated with angina pectoris and myocardial infarction in Russian men. PMID: 25842860
    22. Bradykinin increases IL-6 production via B2R and the ERK pathway, thereby contributing to the invasion and migration of colorectal cancer cells. PMID: 25109623
    23. B2 receptor-mediated relaxation reduced in myometrial vessels in pre-eclampsia PMID: 24304135
    24. We propose that heterodimerization of bradykinin B2 receptor with lamin C is essential to nuclear localization of bradykinin B2 receptor and plays an important role in cell signaling and function. PMID: 24211782
    25. Bradykinin activates multiple signal transduction pathways in human trabecular meshwork cells via B2-receptors that also mediate intraocular pressure reduction PMID: 24236827
    26. These results suggest that reflex muscle vasodilation and ACE activity in response to exercise training are modulated by BDKRB gene +9/-9 polymorphism in healthy individuals. PMID: 23613132
    27. Bradykinin induces ATP release from human subcutaneous fibroblasts via connexin and pannexin-1-containing hemichannels leading to [Ca2+]i mobilization through the cooperation of B2 and P2Y12 receptors PMID: 24047499
    28. Bradykinin induced asthmatic fibroblast/myofibroblast activities via bradykinin B2 receptor and different MAPK pathways. PMID: 23588115
    29. Our data suggest that the B -9 allele and reduced ACE activity are associated with both ACE-AE and ACE-cough. PMID: 23730990
    30. Dominant negative (GDP-locked)-Rab5 and -Rab11 reproduced the effects of inhibitors of tubulin and actin, respectively, on the cycling of bradykinin B receptor. PMID: 23454239
    31. These studies have provided evidence of a functional endogenously expressed B-receptor system in the ciliary muscle that appears to be involved in modulating intraocular pressure. PMID: 23805043
    32. there is a higher frequency of the D allele (high plasma ACE activity) and +9 allele (lower B2R expression) in transplant patients compared with control individuals PMID: 23362199
    33. Triceps brachii morphological response to targeted strength training--hypertrophy--is related to bradykinin type (BK)2 receptor polymorphisms. PMID: 23127247
    34. Our findings suggest that both eNOS and bradykinin B2 receptor genotypes may affect the antihypertensive responses to enalapril. PMID: 22706620
    35. In coronary artery disease patients, bradykinin-B2-receptor downregulation on endothelial repair-promoting circulating mononuclear cells substantially impairs bradykinin-dependent endothelial repair. PMID: 23275384
    36. results suggest that the co-existence of ACE (D/D), BDKRB2 (+9/-9) or LEP (G/A) genotypes in female athletes might be correlated with a superior level of physical performance PMID: 23176367
    37. Suggest that the BDKRB2 +9/-9 polymorphism may act as a genetic modulator of glucose homeostasis and increase susceptibility to diabetes. PMID: 23243416
    38. Bradykinin up-regulates B(2) receptor expression (P<0.05) and stimulate IL-8 release (P<0.001) in BEAS-2B cells. PMID: 22935637
    39. Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. PMID: 23132855
    40. The BDKRB2-58T/C gene polymorphism is associated with increased EH risk. The results of this study suggest that carriers of the -58C allele are susceptible to EH. PMID: 22900090
    41. Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCdelta/c-Src dependent signaling pathway. PMID: 22653778
    42. The +9/-9 bp polymorphisms of BDKRB2 gene may be used as a genetic marker for the susceptibility and severity of OA. PMID: 23093849
    43. expression showed a growing trend with grade of endometrial cancer, reaching the peak in grade 2, whereas grade 3 was characterized by a decrease in transcriptional activity PMID: 22706224
    44. Maximakinin is an agonist of the human and rabbit B(2)R with a 8-12 fold lesser potency. PMID: 22108573
    45. While -58C>T polymorphism did not reveal any association with essential hypertension, +/-9 bp polymorphism showed a significant association with high risk for heterozygotes (+9/-9) when tested against the pooled frequencies of homozygotes. PMID: 22468762
    46. Capillary electrophoresis is a rapid, accurate and sensitive method for genotyping the 9-bp exon 1 insertion/deletion polymorphism in BDKRB2. PMID: 22304584
    47. Tested the influence of the interaction between the BDKRB2 -9/+9 and the GNB3 C825T (rs5443) genotypes in relation to endurance performance. There was no interaction between BDKRB2 -9/+9 and GNB3 C825T polymorphisms in relation to endurance. PMID: 21210858
    48. Results demonstrate that helix 8 of the B(2)R plays a crucial role not only in efficient trafficking to the plasma membrane or the activation of G proteins but also for the interaction of the B(2)R with GRK2/3 and beta-arrestins. PMID: 22016392
    49. Aging cardiac endothelial cells gradually lose their capacity to express BK-2Rs. PMID: 21986469
    50. High molecular weight kininogen activates B2 receptor signaling pathway in human vascular endothelial cells. PMID: 21586566

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Bradykinin receptor subfamily, BDKRB2 sub-subfamily
  • 组织特异性：
    Ubiquitous. Widespread in normal smooth muscle tissue and neurons.
  • 数据库链接：

    HGNC: 1030

    OMIM: 113503

    KEGG: hsa:624

    STRING: 9606.ENSP00000307713

    UniGene: Hs.654542