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  4. Recombinant Human BTB/POZ domain-containing protein KCTD8 (KCTD8)

Recombinant Human BTB/POZ domain-containing protein KCTD8 (KCTD8)

  • 货号：
    CSB-YP765093HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP765093HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP765093HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP765093HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP765093HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KCTD8
  • Uniprot No.：
  • 别名：
    KCTD8; BTB/POZ domain-containing protein KCTD8
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-473
  • 氨基酸序列
    MALKDTGSGG STILPISEMV SSSSSPGASA AAAPGPCAPS PFPEVVELNV GGQVYVTKHS TLLSVPDSTL ASMFSPSSPR GGARRRGELP RDSRARFFID RDGFLFRYVL DYLRDKQLAL PEHFPEKERL LREAEYFQLT DLVKLLSPKV TKQNSLNDEG CQSDLEDNVS QGSSDALLLR GAAAAVPSGP GAHGGGGGGG AQDKRSGFLT LGYRGSYTTV RDNQADAKFR RVARIMVCGR IALAKEVFGD TLNESRDPDR QPEKYTSRFY LKFTYLEQAF DRLSEAGFHM VACNSSGTAA FVNQYRDDKI WSSYTEYIFF RPPQKIVSPK QEHEDRKHDK VTDKGSESGT SCNELSTSSC DSHSEASTPQ DNPSSAQQAT AHQPNTLTLD RPSKKAPVQW IPPPDKRRNS ELFQTLISKS RETNLSKKKV CEKLSVEEEM KKCIQDFKKI HIPDYFPERK RQWQSELLQK YGL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
  • 基因功能参考文献：
    1. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis. PMID: 22930747
    2. KCTD8 might modulate adverse effects of smoking during pregnancy on brain development via apoptosis triggered by low intracellular levels of potassium, possibly reducing the number of progenitor cells PMID: 22156575
  • 亚细胞定位：
    Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane.
  • 数据库链接：

    HGNC: 22394

    KEGG: hsa:386617

    UniGene: Hs.479644