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  4. Recombinant Human Basic leucine zipper transcriptional factor ATF-like 3 (BATF3)

Recombinant Human Basic leucine zipper transcriptional factor ATF-like 3 (BATF3)

  • 货号：
    CSB-YP882082HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP882082HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP882082HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP882082HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP882082HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BATF3
  • Uniprot No.：
  • 别名：
    BATF3; SNFTBasic leucine zipper transcriptional factor ATF-like 3; B-ATF-3; 21 kDa small nuclear factor isolated from T-cells; Jun dimerization protein p21SNFT
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-127
  • 氨基酸序列
    MSQGLPAAGS VLQRSVAAPG NQPQPQPQQQ SPEDDDRKVR RREKNRVAAQ RSRKKQTQKA DKLHEEYESL EQENTMLRRE IGKLTEELKH LTEALKEHEK MCPLLLCPMN FVPVPPRPDP VAGCLPR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.
  • 基因功能参考文献：
    1. The s identified highly significant associations with better melanoma overall survival for rs6673928, impacting IL19 expression (HR, 0.56; 95% CI, 0.41-0.77; P = 0.0002) and rs6695772, controlling the expression of BATF3 (HR, 1.64; 95% CI, 1.19-2.24; P = 0.0019). PMID: 26733611
    2. Basic Leucine Zipper ATF-Like Transcription Factor 3 (BATF3), an AP-1 family transcription factor, is a glucocorticoid receptor coregulator whose interaction with glucocorticoid receptor is modulated by the lever arm. PMID: 28708849
    3. Batf3-dependent dendritic cells elicit the rejection of cells and grafts expressing mismatched minor histocompatibility antigens. PMID: 26034174
    4. correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions PMID: 12087103
    5. overexpression of p21SNFT in HepG2 cells leads to repression of matrix metalloproteinase-1 by 70-80% PMID: 15467742

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family
  • 数据库链接：

    HGNC: 28915

    OMIM: 612470

    KEGG: hsa:55509

    STRING: 9606.ENSP00000243440

    UniGene: Hs.62919