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  4. Recombinant Human Biorientation of chromosomes in cell division protein 1 (BOD1)

Recombinant Human Biorientation of chromosomes in cell division protein 1 (BOD1)

  • 中文名称：
    Recombinant Human Biorientation of chromosomes in cell division protein 1(BOD1),Yeast
  • 货号：
    CSB-YP846637HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Biorientation of chromosomes in cell division protein 1(BOD1),Yeast
  • 货号：
    CSB-EP846637HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Biorientation of chromosomes in cell division protein 1(BOD1),Yeast
  • 货号：
    CSB-EP846637HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Biorientation of chromosomes in cell division protein 1(BOD1),Yeast
  • 货号：
    CSB-BP846637HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Biorientation of chromosomes in cell division protein 1(BOD1),Yeast
  • 货号：
    CSB-MP846637HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BOD1
  • Uniprot No.：
  • 别名：
    BOD1; FAM44BBiorientation of chromosomes in cell division protein 1; Biorientation defective protein 1; Protein FAM44B
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-185
  • 氨基酸序列
    MADGGGGGGT GAVGGGGTSQ ASAGAATGAT GASGGGGPIN PASLPPGDPQ LIALIVEQLK SRGLFDSFRR DCLADVDTKP AYQNLRQKVD NFVSTHLDKQ EWNPTMNKNQ LRNGLRQSVV QSGMLEAGVD RIISQVVDPK LNHIFRPQIE RAIHEFLAAQ KKAAVPAPPP EPEGQDPPAP SQDTS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.
  • 基因功能参考文献：
    1. Kinetochore targeting of Bod1 depends on Ndc80 and not PP2A-B56. Bod1 depletion functionally affects Ndc80 phosphorylation at S55. PMID: 29142109
    2. these results suggest that radiation alters miR-142-3p and Bod1 expression in carcinoma cells, and thus contributes to early stages of radiation-induced genomic instability PMID: 27527863
    3. we established two Drosophila models, where neuron-specific knockdown of BOD1 caused pronounced learning deficits and significant abnormalities in synapse morphology. Together our results reveal novel postmitotic functions of BOD1 as well as pathogenic mechanisms that strongly support a causative role of BOD1 deficiency in the aetiology of intellectual disability. PMID: 27166630
    4. Bod1 regulates protein phosphatase 2A at mitotic kinetochores. PMID: 24157919
    5. Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. PMID: 17938248
    6. siRNA depeletion of Fam44B (named Bod1 - Biorientation Defective 1 in this publication) resulted in persistent chromosome congression defects in metaphase. PMID: 17938248

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase.
  • 蛋白家族：
    BOD1 family
  • 数据库链接：

    HGNC: 25114

    OMIM: 616745

    KEGG: hsa:91272

    STRING: 9606.ENSP00000309644

    UniGene: Hs.425091