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  4. Recombinant Human Brain and acute leukemia cytoplasmic protein (BAALC)

Recombinant Human Brain and acute leukemia cytoplasmic protein (BAALC)

  • 中文名称：
    Recombinant Human Brain and acute leukemia cytoplasmic protein(BAALC),Yeast
  • 货号：
    CSB-YP845170HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Brain and acute leukemia cytoplasmic protein(BAALC),Yeast
  • 货号：
    CSB-EP845170HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Brain and acute leukemia cytoplasmic protein(BAALC),Yeast
  • 货号：
    CSB-EP845170HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Brain and acute leukemia cytoplasmic protein(BAALC),Yeast
  • 货号：
    CSB-BP845170HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Brain and acute leukemia cytoplasmic protein(BAALC),Yeast
  • 货号：
    CSB-MP845170HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BAALC
  • Uniprot No.：
  • 别名：
    BAALC; BAALC_HUMAN; Brain and acute leukemia cytoplasmic; Brain and acute leukemia cytoplasmic protein; FLJ12015
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-180
  • 氨基酸序列
    GCGGSRADA IEPRYYESWT RETESTWLTY TDSDAPPSAA APDSGPEAGG LHSVLEAEKS KIKAPTDSVS DEGLFSASKM APLAVFSHGM LEDGLPSNGV PRSTAPGGIP NPEKKTNCET QCPNPQSLSS GPLTQKQNGL QTTEAKRDAK RMPAKEVTIN VTDSIQQMDR SRRITKNCVN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A.
  • 基因功能参考文献：
    1. despite of their well-known adverse role in prognosis of AML, neither BAALC nor ERG expression levels at diagnosis had effect on survival of AML patients who underwent allo-HSCT. PMID: 29696374
    2. BAALC expression-based minimal residual disease detection during therapy may be considered a strategy to identify patients at high risk of relapse. PMID: 27662611
    3. Study provide evidence for an association of rs62527607 [GT] SNP of BAALC gene with multidrug resistance in childhood ALL. PMID: 27372260
    4. BAALC and ERG genes are specific significant molecular markers in acute myeloid leukemia disease progression, response to treatment and survival. PMID: 26625814
    5. demonstrated that BAALC blocks ERK-mediated monocytic differentiation of acute myeloid leukemia cells by trapping Kruppel-like factor 4 (KLF4) in the cytoplasm and inhibiting its function in the nucleus PMID: 26050649
    6. combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers PMID: 26430723
    7. study indicates that overexpression of BAALC serves as an independent prognostic biomarker in acute myeloid leukemia PMID: 25428390
    8. Evaluating WT1 and BAALC gene expression at diagnosis may improve standard risk stratification and possibly refine the therapeutic approach for Myelodysplastic Syndromes patients. PMID: 26012361
    9. Thus low MDR1/low BAALC expression identifies a subgroup of intermediate cytogenetic risk AML patients with a remarkably good long-term outcome achieved by chemotherapy alone. PMID: 24855032
    10. miR-3151 introns within BAALC have roles in driving leukemogenesis by deregulating the TP53 pathway PMID: 24736457
    11. Higher BAALC expression and FLT3-ITD mutation, both individually and in combination, were associated with worse survival outcomes in CN-AML, and this was also applicable in NPM1-mutated CN-AML, known as a favorable-risk group. PMID: 23647058
    12. BAALC overexpression retains its negative prognostic role across all cytogenetic risk groups in acute myeloid leukemia patients. PMID: 23760853
    13. higher post-HSCT BAALC and WT1 expressions in patients with CBF-AML may be good markers of minimal residual disease for the prediction of survival and relapse after HSCT. PMID: 23672350
    14. Investigated the prognostic impact of brain and acute leukemia, cytoplasmic (BAALC) expression in acute myeloid leukemia with normal karyotype. PMID: 23865362
    15. data show that higher levels of VEGF-A(CSF) are closely related to CNS leukemia (CNSL), and VEGF-A(CSF) may be a better predictor than the other risk factors elucidating the pathogenesis and development of CNSL PMID: 23287429
    16. high expression of miR-3151 is an independent prognosticator for poor outcome in cytogenetically normal-AML and affects different outcome end points than its host gene, BAALC PMID: 22529287
    17. A high MEBE (MN1,ERG, BAALC, EVI1) expression score is an unfavorable prognostic marker in Myelodysplastic syndrome and is associated with an increased risk for progression to Acute myeloid leukemia. PMID: 22488406
    18. identify a heritable genomic feature predisposing to overexpression of an oncogene (BAALC), thereby possibly leading to enhanced AML leukemogenesis PMID: 22493267
    19. These findings indicate that BAALC gene is "paused" and that in leukemia cells its transcription can be activated or repressed by mechanisms acting on epigenetic marks. PMID: 22197554
    20. Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia. PMID: 21967978
    21. High BAALC expression levels are associated with acute myeloid leukemia. PMID: 20841507
    22. 1-5-6-8 BAALC isoform expression may be associated with an adverse prognosis in pediatric acute myeloid leukemia with normal karyotype. PMID: 20495894
    23. In contrast to BAALC, which likely represents only a surrogate marker of treatment failure in acute leukemia, IGFBP7 regulates the proliferation of leukemic cells and might be involved in chemotherapy resistance PMID: 20535151
    24. Overexpression of BAALC and ERG either separate or concomitant predict adverse clinical outcome and may define important risk factor in cytogenetically normal acute myeloid leukemia PMID: 19555438
    25. High BAALC expression is associated with chemoresistance in adult B-precursor acute lymphoblastic leukemia. PMID: 20065290
    26. CEBPA mutation status and BAALC expression are important prognostic factors in acute myeloid leukemia patients with normal cytogenetics. PMID: 20306678
    27. BAALC is a relevant prognostic marker in intermediate-risk acute myeloid leukemia patients, with high versus low BAALC expressors showing lower complete remission rate after salvage therapy. PMID: 19943049
    28. The BAALC gene, located on chromosome 8q22.3, encodes a protein with no homology to any known proteins or functional domains. PMID: 15604894
    29. High transcript levels occur in leukemic blasts from some patients with acute myeloid leukemia. PMID: 15749074
    30. Low expression of both ERG and BAALC identifies T-ALL patients with a distinctly favorable long-term outcome. PMID: 17646667
    31. high BAALC expression is an independent adverse prognostic factor and is associated with a specific gene-expression profile PMID: 18378853
    32. Up-regulation of BAALC gene may be an important alteration in AML-M2 patients with t(8;21) translocation. PMID: 18671757
    33. Presence of both EVI1 and/or BAALC in chronic myeloid patients was found to modulate the disease pattern PMID: 18752846

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  • 亚细胞定位：
    Cytoplasm. Cell junction, synapse, synaptosome. Membrane raft. Cell junction, synapse, postsynaptic density.
  • 组织特异性：
    Predominantly expressed in neuroectoderm-derived tissues. Expressed in the brain and spinal cord, and at low levels, in the adrenal gland. In the bone marrow, confined to the CD34+ progenitor cells. Not found in peripheral blood mononuclear cells, nor lym
  • 数据库链接：

    HGNC: 14333

    OMIM: 606602

    KEGG: hsa:79870

    UniGene: Hs.533446