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  4. Recombinant Human Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1)

Recombinant Human Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1)

  • 中文名称：
    Recombinant Human Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1(BAIAP2L1),Yeast
  • 货号：
    CSB-YP887045HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1(BAIAP2L1),Yeast
  • 货号：
    CSB-EP887045HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1(BAIAP2L1),Yeast
  • 货号：
    CSB-EP887045HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1(BAIAP2L1),Yeast
  • 货号：
    CSB-BP887045HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1(BAIAP2L1),Yeast
  • 货号：
    CSB-MP887045HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BAIAP2L1
  • Uniprot No.：
  • 别名：
    BAI1 associated protein 2 like 1; BAI1 associated protein 2 like protein 1; BAI1-associated protein 2-like protein 1; Baiap2l1; BI2L1_HUMAN; Brain specific angiogenesis inhibitor 1 associated protein 2 like protein 1; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; FLJ42275; Insulin receptor tyrosine kinase substrate; IRTKS
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-511
  • 氨基酸序列
    MSRGPEEVNR LTESTYRNVM EQFNPGLRNL INLGKNYEKA VNAMILAGKA YYDGVAKIGE IATGSPVSTE LGHVLIEISS THKKLNESLD ENFKKFHKEI IHELEKKIEL DVKYMNATLK RYQTEHKNKL ESLEKSQAEL KKIRRKSQGS RNALKYEHKE IEYVETVTSR QSEIQKFIAD GCKEALLEEK RRFCFLVDKH CGFANHIHYY HLQSAELLNS KLPRWQETCV DAIKVPEKIM NMIEEIKTPA STPVSGTPQA SPMIERSNVV RKDYDTLSKC SPKMPPAPSG RAYTSPLIDM FNNPATAAPN SQRVNNSTGT SEDPSLQRSV SVATGLNMMK KQKVKTIFPH TAGSNKTLLS FAQGDVITLL IPEEKDGWLY GEHDVSKARG WFPSSYTKLL EENETEAVTV PTPSPTPVRS ISTVNLSENS SVVIPPPDYL ECLSMGAAAD RRADSARTTS TFKAPASKPE TAAPNDANGT AKPPFLSGEN PFATVKLRPT VTNDRSAPII R
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.
  • 基因功能参考文献：
    1. Rho family GTPases use the I-BAR proteins, IRSp53 (also known as BAIAP2), IRTKS and Pinkbar, as a central mechanism to modulate cell morphology. PMID: 27278019
    2. IRTKS promoted serum-induced cell migration along with enhanced phosphorylation of mitogen activated kinases Erk1/2 and p38, and activation of small GTPases Rac1 and Cdc42. In addition, cells overexpressing IRTKS exhibited an increased polarity characterized by elongated cytoplasm and extensive lamellipodia at leading edges. PMID: 27693783
    3. Upregulation of BAIAP2L1 is associated with ovarian cancer. PMID: 26222696
    4. Lacking the Bin-Amphiphysin-Rvs (BAR) dimerization domain of BAIAP2L1. PMID: 25589496
    5. IRTKS can interact with epidermal growth factor receptor (EGFR), results in the phosphorylation of extracellular signal-regulated kinase PMID: 23693078
    6. Identification of a novel oncogenic FGFR3-BAIAP2L1 fusion protein in bladder cancer. PMID: 23175443
    7. These data suggest that IRTKS is a novel regulator of p53, modulating low level of MDM2-mediated p53 ubiquitination in unstressed cells. PMID: 21887275
    8. data suggest Src-stimulated IRTKS phosphorylation is essential for its function in cell motility PMID: 21840312
    9. Results describe the NMR structure of insulin receptor tyrosine kinase substrate (IRTKS) SH3 domain in complex with a repeat from Escherichia coli-secreted protein F-like protein encoded on prophage U (EspF(U)). PMID: 21098279
    10. Study characterised IRTKS, which has widespread tissue distribution, is a substrate for the insulin receptor and binds Rac, and expression of IRTKS induces clusters of short actin bundles rather than filopodia-like protrusions. PMID: 17430976
    11. Screening of the mammalian SH3 proteome for the ability to bind EspF(U) identified the SH3 domain of insulin receptor tyrosine kinase substrate (IRTKS), a factor known to regulate the cytoskeleton. PMID: 19366662

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
  • 数据库链接：

    HGNC: 21649

    OMIM: 611877

    KEGG: hsa:55971

    STRING: 9606.ENSP00000005260

    UniGene: Hs.656063