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  4. Recombinant Human C-type lectin domain family 4 member M (CLEC4M), partial

Recombinant Human C-type lectin domain family 4 member M (CLEC4M), partial

  • 中文名称：
    Recombinant Human C-type lectin domain family 4 member M(CLEC4M),partial,Yeast
  • 货号：
    CSB-YP862003HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human C-type lectin domain family 4 member M(CLEC4M),partial,Yeast
  • 货号：
    CSB-EP862003HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human C-type lectin domain family 4 member M(CLEC4M),partial,Yeast
  • 货号：
    CSB-EP862003HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human C-type lectin domain family 4 member M(CLEC4M),partial,Yeast
  • 货号：
    CSB-BP862003HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human C-type lectin domain family 4 member M(CLEC4M),partial,Yeast
  • 货号：
    CSB-MP862003HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CLEC4M
  • Uniprot No.：
  • 别名：
    C type lectin domain family 4; member M; C-type lectin domain family 4 member M; CD209 antigen like; CD209 antigen like protein 1; CD209 antigen-like protein 1; CD209L; CD209L1; CD299; CD299 antigen; CLC4M_HUMAN; CLEC4M; DC SIGN related protein; DC SIGN2; DC SIGNR; DC-SIGN-related protein; DC-SIGN2; DC-SIGNR; DCSIGN related protein; DCSIGNR; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; HP10347; L SIGN; L-SIGN; Liver/lymph node specific ICAM3 grabbing nonintegrin; Liver/lymph node-specific ICAM-3-grabbing non-integrin; LSIGN; Mannose binding C type lectin DC SIGNR; MGC129964; MGC47866
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.; (Microbial infection) Acts as an attachment receptor for Ebolavirus.; (Microbial infection) Acts as an attachment receptor for Hepatitis C virus.; (Microbial infection) Acts as an attachment receptor for HIV-1.; (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.; (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.; (Microbial infection) Acts as an attachment receptor for Influenzavirus.; (Microbial infection) Acts as an attachment receptor for SARS-CoV.; (Microbial infection) Acts as an attachment receptor for West-nile virus.; (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.; (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.; (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.
  • 基因功能参考文献：
    1. heterozygous VNTR genotypes 57 and 67 of CLEC4M were highly enriched and are the most likely mechanism through which CLEC4M contributes to disease in the Swedish type 1 VWD population PMID: 29389944
    2. DC-SIGNR promoted gastric cancer liver metastasis mediated with HNRNPKP2 which expression was regulated by STAT5A. And HNRNPKP2 decreased the expression of downstream target gene CXCR4. These findings indicated potential therapeutic candidates for gastric cancer liver metastasis. PMID: 28403883
    3. the neck domains of DC-SIGN and DC-SIGNR can contribute to the different functions of these receptors by presenting the sugar-binding sites in different contexts. PMID: 27859859
    4. Together, these studies confirm a role for C-type lectin receptors DC-SIGN and L-SIGN as attachment factors and entry receptors for human metapneumovirus infection. PMID: 27334579
    5. DC-SIGNR VNTR and DC-SIGN VNTR were not associated with the risk of pulmonary tuberculosis in a sample of Iranian population PMID: 27309478
    6. CD209L variation may influence susceptibility to HIV-1, response to treatment, and disease progression. PMID: 25656622
    7. DC-SIGNR expression in peripheral blood mononuclear cells was higher in HIV-1-infected patients, and its positive correlation with viral load and negative with CD4+ T cells counts suggest a potential role of DC-SIGNR in HIV-1 infection. PMID: 26313015
    8. Study demonstrated that serum levels of DC-SIGNR in lung cancer patients were significantly lower than those in healthy individuals, and correlated significantly with brain metastasis and serum NK cells percentage. PMID: 26150177
    9. Genetic variations in STXBP5 and CLEC4M are associated with VWF level variation in type 1, but not in type 2 von Willebrand disease. PMID: 25832887
    10. of an association between CD209 and CD209L polymorphisms and tuberculosis development in a Brazilian population PMID: 24874302
    11. DC-SIGN and DC-SIGNR are blood-based molecular markers that can potentially be used for the diagnosis of early stage patients PMID: 25504222
    12. Japanese encephalitis virus infected cells through three virus receptors: DC-SIGN, DC-SIGNR and LSECtin. PMID: 24623090
    13. The results indicate that neck region polymorphism of L-SIGN can influence the outcome of HCV infection and the four-tandem repeat is associated with clearance of HCV infection. PMID: 24283933
    14. CLEC4M and CD81 both are still crucial for hepatitis C virus entry into hepatocytes. PMID: 24965233
    15. The CLEC4M carbohydrate recognition domain rapidly and reversibly releases glycan ligands and Ca(2+) at reduced pH. PMID: 24976257
    16. these results provide evidence that hDC- and hL-SIGN can mediate the entry of Junin virus into cells, and may play an important role in virus infection and dissemination in the host. PMID: 24183720
    17. Up-regulation of Raf-MEK-ERK pathway by HCV E2 via L-SIGN provides new insights into signaling cascade of L-SIGN PMID: 23292357
    18. Our findings suggested that DC-SIGNR neck region VNTR polymorphism was not directly associated with hosts' predisposition for HIV-1 infection and not associated with the HIV-1 routes of infection. PMID: 23602836
    19. DC-SIGNR has a role in expression of lactic acid dehydrogenase and beta2-microglobulin in non-Hodgkin lymphoma PMID: 23859015
    20. genetic polymorphism is associated with HIV-1 infection PMID: 23354840
    21. Variable number of tandem repeats in CLEC4M is associated with type 1 von Willebrand disease. PMID: 23529928
    22. Both K3 and K5 preferentially associate with DC-SIGN and DC-SIGNR, mediating their ubiquitylation and degradation. PMID: 23460925
    23. Polymorphisms in DC-SIGN and L-SIGN genes are associated with HIV-1 vertical transmission in a Northeastern Brazilian population. PMID: 22902397
    24. analysis of attachment factor DC-SIGNR on cells in neutralization studies failed to identify a correlation between DC-SIGNR expression and antibody-mediated protection; studies suggest cellular attachment factor expression is not a significant contributor to potency of neutralizing antibodies to flaviviruses PMID: 23312596
    25. VNTR polymorphism of the DC-SIGNR gene is associated with a moderate effect on host susceptibility to HIV-1 infection, similar to CCR5 gene deletion PMID: 22957026
    26. Findings do not support the hypothesis that the origin of the variable number tandem repeat (VNTR} alleles of CLEC4M were arisen by independent (separate) mutation events. PMID: 22279577
    27. data demonstrate that the signaling events mediated by RSV G interactions with DC/L-SIGN are immunomodulatory and diminish DC activation, which may limit induction of RSV-specific immunity PMID: 22090124
    28. There were multiple genotypes of the gene DC-SIGNR in the pregnant women infected with HBV. PMID: 22338216
    29. Upon binding to membrane-anchored ligand, DC-SIGNR undergoes a conformational change similar to that previously observed for DC-SIGN. PMID: 21650186
    30. Together, these data indicate that human C-type lectins (DC-SIGN and L-SIGN) can mediate attachment and entry of influenza viruses independently of cell surface sialic acid. PMID: 21191006
    31. 9/5 genotype distribution frequency of DC-SIGNR's exon 4 in patients with hepatitis C is significantly higher and may be associated with HCV infection susceptibility. PMID: 18171520
    32. these results suggest that the variation of the tested DC-SIGNR genotypes affects the efficacy of HIV-1 trans-infection by affecting the amounts of the protein expressed on the cell surface. PMID: 20152818
    33. Our study indicated that there was absence of association between the neck region polymorphism of DC-SIGNR and longevity in Han Chinese population PMID: 20003397
    34. DC-SIGNR plays a crucial role in MTCT of HIV-1 and impaired placental DC-SIGNR expression increases risk of transmission PMID: 19809496
    35. DC-SIGNR was mainly expressed in the membrane and plasm in placental trophoblast cells. PMID: 20108443
    36. determinants in DC-SIGN necessary for HIV-1 transmission and the differences between DC-SIGN and L-SIGN that affect HIV-1 interactions PMID: 19833723
    37. Crystal structures of carbohydrate-recognition domains of DC-SIGNR bound to oligosaccharide, in combination with binding studies, reveal that it selectively recognizes endogenous high-mannose oligosaccharides PMID: 11739956
    38. mediates cellular entry by Ebola virus in cis and in trans PMID: 12050398
    39. reasons underlying the restricted distribution of DC-SIGNR; and expression in relation to HIV entry receptors PMID: 12152166
    40. Review. This article reviews the interaction of DC-SIGN & DC-SIGNR with HIV and Ebola & discusses the mechanism of DC-SIGN-mediated viral transmission. PMID: 12223058
    41. the influx or proliferation of DC-SIGN+ immature and mature DCs and L-SIGN+ cells is dynamically regulated PMID: 15111305
    42. data demonstrate for the first time that lectins DC-SIGN and L-SIGN differ in their carbohydrate binding profiles PMID: 15184372
    43. largely expressed on endothelial cells in liver sinusoids; results demonstrate that hepatitis C pseudoviruses captured by L-SIGN+ or DC-SIGN+ cells efficiently transinfect adjacent human liver cells PMID: 15371595
    44. can serve as an alternative receptor for SARS coronavirus PMID: 15496474
    45. crystal forms of truncated DC-SIGNR comprising two neck repeats and the carbohydrate-recognition domain reveal that the CRDs are flexibly linked to the neck, which contains alpha-helical segments interspersed with non-helical regions PMID: 15509576
    46. crystal structure of DC-SIGNR with its last repeat region PMID: 15784257
    47. DC-SIGNR, in addition to DC-SIGN, should be considered as a cofactor in sexual HIV-1 transmission; soluble isoforms, in particular, may modulate the efficiency of viral transmission and dissemination. PMID: 15812562
    48. A change in the number of DC-SIGN-related (DC-SIGNR) repeats may influence its normal functions as well as its binding capacity to viral and nonviral pathogens. PMID: 16061998
    49. genetic risk association study shows that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. PMID: 16369534
    50. Recognizes pathogens and contributes to innate immunity. PMID: 16386217

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Single-pass type II membrane protein.; [Isoform 2]: Cell membrane; Single-pass type II membrane protein.; [Isoform 3]: Cell membrane; Single-pass type II membrane protein.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted.; [Isoform 7]: Secreted.; [Isoform 10]: Secreted.
  • 组织特异性：
    Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.
  • 数据库链接：

    HGNC: 13523

    OMIM: 605872

    KEGG: hsa:10332

    STRING: 9606.ENSP00000316228

    UniGene: Hs.421437