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  4. Recombinant Human CCAAT/enhancer-binding protein delta (CEBPD)

Recombinant Human CCAAT/enhancer-binding protein delta (CEBPD)

  • 货号：
    CSB-YP005182HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005182HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005182HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005182HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CEBPD
  • Uniprot No.：
  • 别名：
    C/EBP delta; C/EBP related protein 3; CCAAT/enhancer binding protein (C/EBP) delta; CCAAT/enhancer binding protein delta; CCAAT/enhancer-binding protein delta; CEBP D; CEBPD; CEBPD_HUMAN; CELF; Crp 3; Crp3; NF IL6 beta; NF-IL6-beta; Nuclear factor NF IL6 beta; Nuclear factor NF-IL6-beta
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-269
  • 氨基酸序列
    SAALFSLDG PARGAPWPAE PAPFYEPGRA GKPGRGAEPG ALGEPGAAAP AMYDDESAID FSAYIDSMAA VPTLELCHDE LFADLFNSNH KAGGAGPLEL LPGGPARPLG PGPAAPRLLK REPDWGDGDA PGSLLPAQVA ACAQTVVSLA AAGQPTPPTS PEPPRSSPRQ TPAPGPAREK SAGKRGPDRG SPEYRQRRER NNIAVRKSRD KAKRRNQEMQ QKLVELSAEN EKLHQRVEQL TRDLAGLRQF FKQLPSPPFL PAAGTADCR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB.
  • 基因功能参考文献：
    1. gemcabene decreases CRP by C/EBP-delta and NF-kappaB-mediated transcriptional mechanism and suppresses IL-6 and IL-1beta-induced CRP production. PMID: 29644527
    2. tudy underscores how CEBPD functions at the junction of inflammation and lipid accumulation in M1 macrophages PMID: 28859294
    3. the EGFR/STAT3 pathway contributed to CDDP-induced CEBPD expression in UCUB cells. Gefitinib and S3I-201 treatment significantly reduced the expression of CEBPD and enhanced the sensitivity of CDDP-resistant UCUB cells to CDDP and paclitaxel PMID: 27435393
    4. These findings demonstrate a critical function for the astrocytic CEBPD, and point to miR-135a antagonist as an attractive therapeutic target for the treatment of Alzheimer's disease. PMID: 26208701
    5. These findings identify a molecular mechanism by which ERalpha signaling reduces the aggressiveness of cancer cells, and demonstrate that C/EBPdelta can have different functions in different types of cancer. PMID: 27181204
    6. CREB overexpression increased CCAAT-enhancer-binding protein-delta (C/EBPdelta) levels to cause myeloid differentiation arrest, and the silencing of CREB-C/EBPdelta axis restored myeloid terminal differentiation PMID: 27118402
    7. Data suggest that proinflammatory cytokine interleukin-1beta (IL1B) up-regulates hepcidin expression in hepatocytes; inflammation induces IL1B production in Kupffer cells and hepatocytes; IL1B up-regulates CEBPD (CCAAT/enhancer binding protein delta) expression in hepatocytes; up-regulation of CEBPD expression up-regulates hepcidin transcription. PMID: 28438835
    8. the C/EBPD binding site is required for RU486-mediated activation of the CHOP promoter. PMID: 26174226
    9. Results suggest that CCAAT/enhancer binding protein delta (CEBPD) could be a useful diagnostic marker and therapeutic target in hepatocellular carcinoma (HCC). PMID: 26358750
    10. CEBPD amplification and overexpression is associated with urothelial carcinoma. PMID: 26307680
    11. Knock-down of C/EBPdelta expression in pericytes following immune stimulation increased chemokine and adhesion molecule expression. PMID: 26166618
    12. We have discovered the CEBPD-hypoxia-inducible factor-1 (HIF-1) pathway as a new HIF-1-regulating fundamental mechanism in tubular epithelial cells for the cellular protection against kidney injury. PMID: 25692954
    13. s found that CK2 bound to C/EBPdelta, which might help to target CK2 to the transcriptional machinery where it can phosphorylate other transcription factors or co-activators. PMID: 25680545
    14. Data indicate that dysfunction of the Rho-associated kinase 2 (Rock2)-p-GSK3beta/beta-catenin-CCAAT/enhancer-binding protein delta (CEBPD) regulatory circuitry may contribute to the tumorigenic characteristic of hepatocellular carcinoma (HCC). PMID: 25771860
    15. GSK3beta-mediated CEBPD phosphorylation in astrocytes plays an important role in the activation of microglia. PMID: 23993701
    16. the inflammatory PGE-HuR-C/EBPdelta axis in macrophages promotes tumor progression by preventing the phagocytosis of tumor cells and inducing immunosuppressive cytokine production. PMID: 23861541
    17. CEBPD inhibits FBXW7 expression and augments HIF-1 alpha expression and activity under hypoxia PMID: 21076392
    18. CEBPD supports inflammatory signaling through activation of the TLR4 gene; and is downregulated by FBXW7 alpha following phosphorylation by GSK-3 beta. PMID: 23575666
    19. Review article on CEBPD expression, regulation and function with focus on inflammation and cancer. PMID: 24155666
    20. The FRA8I fragile site includes KIAA0146, CEBPD and PRKDC and may have a role in colorectal cancer PMID: 23603433
    21. Findings suggest that CEBPD and its downstream effectors could be biomarkers for the diagnosis of RA and potentially serve as therapeutic targets for RA therapy. PMID: 23028973
    22. This study provides the first demonstration of a role for astrocytic CEBPD and the CEBPD-regulated molecule PTX3 in the accumulation of damaged neurons, which is a hallmark of AD pathogenesis. PMID: 21112127
    23. Src kinase activity downregulates C/EBP-delta protein but not mRNA levels through a SIAH2 E3 ligase-dependent mechanism. PMID: 22037769
    24. new function of CEBP-delta in lymphangiogenesis through regulation of VEGFR3 signaling in lymphatic endothelial cells PMID: 21666710
    25. Data indicate that C/EBPdelta plays a role in late stages of keratinocyte differentiation. PMID: 21072181
    26. HMDB kills cancer cells through activation of CEBPD pathways. PMID: 20971808
    27. C/EBP{delta} and STAT-1 are required for TLR8 transcriptional activity. PMID: 20829351
    28. Common allelic variants in CEBPD were not associated with obesity phenotypes in healthy White Northern European families. PMID: 20460359
    29. found that C/EBPdelta promotes monoubiquitination of the Fanconi anemia complementation group D2 protein (FANCD2), which is necessary for its function in replication-associated DNA repair PMID: 20805509
    30. C/EBPdelta expression may prevent the development of recurrences by inhibition of neoplastic growth in meningiomas PMID: 19806320
    31. Expression of CEBPD reduces cisplatin-induced reactive oxygen species and apoptosis in NTUB1 carcinoma cells by inducing the expression of copper/zinc-superoxide dismutase via direct promoter transactivation. PMID: 20385105
    32. These results suggest a potentially crucial role for NF-kappaB in the IL-1-induced expression of C/EBPdelta, and thereby downstream acute phase protein genes regulated by this transcription factor. PMID: 19800021
    33. A single nucleotide polymorphism in the CEBPD gene was found in 2.9% of patients studied. PMID: 11851384
    34. posttranscriptional and posttranslational regulation in G0 growth-arrested mammary epithelial cells PMID: 12554732
    35. Expression levels of C/EBPdelta in breast tumors were correlated with clinicopathological tumor parameters, expression of estrogen and progesterone receptors (ER, PR), Ki67 immunostaining, and expression of 7 cell-cycle regulatory proteins. PMID: 12825852
    36. C/EBPdelta has a role in abolishing CBP phosphorylation as well as transcriptional activation and could be important in C/EBP-mediated transcription PMID: 12857754
    37. AD tissue sections revealed profuse C/EBPdelta staining of astrocytes, particularly reactive astrocytes surrounding amyloid beta peptide deposits. Substantially less immunoreactivity was observed in comparable sections from controls. PMID: 15212823
    38. results indicate that the C/EBPdelta gene is controlled at multiple levels, consistent with a role for C/EBPdelta in cell cycle control and/or cell fate determination. PMID: 15389878
    39. results demonstrate that "loss of function" alterations in the pSTAT3/C/EBPdelta growth inhibitory signal transduction pathway are relatively common in breast cancer cell lines PMID: 15389879
    40. C EBP delta is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells. PMID: 15486993
    41. Expression of C/EBPdelta in BCR-ABL-positive leukemic cells in blast crisis is sufficient for neutrophil differentiation. PMID: 15674331
    42. IL-6 increases hepatic PAI-1 expression mediated by the -232- to -210-bp region of the promoter containing a C/EBPdelta binding site. PMID: 15718495
    43. the PI3-kinase/p38(MAPK)/CREB pathway contributes to the EGF activation of NF-IL6beta gene expression PMID: 15901830
    44. Small interfering RNA of C/EBPdelta suppressed COX-2 expression, strengthening the role of C/EBPdelta in COX-2 gene transcription. PMID: 16195339
    45. Reduced C/EBPdelta gene expression is associated with breast tumors PMID: 16322893
    46. IL-1 and IL-6 exert directionally similar effects on PAI-1 expression, but the induction involves distinct signaling pathways with a final common mediator, C/EBPdelta. PMID: 16914534
    47. Reverse-transcription polymerase chain reaction confirmed increased expression of GADD45A, BTG2, PDE4B, and CEBPD and downregulation of TOB1 in skeletal muscle intradialysis. PMID: 16997058
    48. C/EBPdelta is a novel tumor suppressor gene in acute myeloid leukemia that is silenced by promoter methylation. PMID: 17234736
    49. C/EBPdelta ubiquitination is not required for proteasome-mediated C/EBPdelta degradation and the presence of ubiquitin does not increase C/EBPdelta degradation by the proteasome. PMID: 17373909
    50. C/EBPdelta, but not DeltaNp63alpha, indefinitely promotes holoclone self-renewal and prevents clonal evolution, suggesting that self-renewal and proliferation are distinct, albeit related, processes in limbal stem cells. PMID: 17562792

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, C/EBP subfamily
  • 数据库链接：

    HGNC: 1835

    OMIM: 116898

    KEGG: hsa:1052

    STRING: 9606.ENSP00000386165

    UniGene: Hs.440829