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  4. Recombinant Human Calmodulin-lysine N-methyltransferase (CAMKMT)

Recombinant Human Calmodulin-lysine N-methyltransferase (CAMKMT)

  • 中文名称：
    Recombinant Human Calmodulin-lysine N-methyltransferase(CAMKMT),Yeast
  • 货号：
    CSB-YP800220HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Calmodulin-lysine N-methyltransferase(CAMKMT),Yeast
  • 货号：
    CSB-EP800220HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Calmodulin-lysine N-methyltransferase(CAMKMT),Yeast
  • 货号：
    CSB-EP800220HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Calmodulin-lysine N-methyltransferase(CAMKMT),Yeast
  • 货号：
    CSB-BP800220HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Calmodulin-lysine N-methyltransferase(CAMKMT),Yeast
  • 货号：
    CSB-MP800220HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CAMKMT
  • Uniprot No.：
  • 别名：
    CAMKMT; C2orf34; CLNMTCalmodulin-lysine N-methyltransferase; CLNMT; CaM KMT; EC 2.1.1.60
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-323
  • 氨基酸序列
    MESRVADAGT GETARAAGGS PAVGCTTRGP VVSAPLGAAR WKLLRQVLKQ KHLDDCLRHV SVRRFESFNL FSVTEGKERE TEEEVGAWVQ YTSIFCPEYS ISLRHNSGSL NVEDVLTSFD NTGNVCIWPS EEVLAYYCLK HNNIFRALAV CELGGGMTCL AGLMVAISAD VKEVLLTDGN EKAIRNVQDI ITRNQKAGVF KTQKISSCVL RWDNETDVSQ LEGHFDIVMC ADCLFLDQYR ASLVDAIKRL LQPRGKAMVF APRRGNTLNQ FCNLAEKAGF CIQRHENYDE HISNFHSKLK KENPDIYEEN LHYPLLLILT KHG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the trimethylation of 'Lys-116' in calmodulin.
  • 基因功能参考文献：
    1. Deletion of CAMKMT is associated with Hypotonia-cystinuria syndrome. PMID: 23794250
    2. The CaM KMT is the major, possibly the single, methyltransferase of calmodulin in human cells with a wide tissue distribution and is a novel Hsp90 client protein. PMID: 23285036
    3. Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. PMID: 20975703
    4. a deletion of C2orf34 causes atypical hypotonia-cystinuria syndrome PMID: 18234729
    5. Two key transcription factors, NRF-2 and YY-1, were further identified to coordinately participate in driving gene expressions of PREPL-C2ORF34 genes pairin an additive manner. PMID: 19575798

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Golgi apparatus.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, CLNMT methyltransferase family
  • 组织特异性：
    Isoform 1 is expressed in brain, liver, muscle colon and lung. Isoform 2 is expressed in colon, testis, kidney and brain. Isoform 1 and isoform 2 are expressed in normal lymphoblastoid cells but not in lymphoblastoid cells from patients with hypotonia-cys
  • 数据库链接：

    HGNC: 26276

    OMIM: 609559

    KEGG: hsa:79823

    STRING: 9606.ENSP00000367755

    UniGene: Hs.468349