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  4. Recombinant Human Calpain small subunit 1 (CAPNS1)

Recombinant Human Calpain small subunit 1 (CAPNS1)

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  • 中文名称：
    Recombinant Human Calpain small subunit 1(CAPNS1)
  • 货号：
    CSB-EP004503HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    CAPNS1
  • Uniprot No.：
  • 别名：
    30K; Calcium activated neutral proteinase; Calcium activated neutral proteinase small subunit; Calcium dependent protease small subunit 1; Calcium dependent protease small subunit; Calcium-activated neutral proteinase small subunit; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit; Calpain 4; Calpain 4 small subunit (30K); Calpain 4 small subunit; Calpain regulatory subunit; Calpain S1; Calpain small polypeptide; Calpain small subunit 1; Calpain4; CalpainS1; CANP; CANP small subunit; CANPS; CAPN 4; CAPN S1; CAPN4; CAPNS 1; CAPNS; Capns1; CDPS; CPNS1_HUMAN; CSS 1; CSS1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    44.3kDa
  • 表达区域：
    1-268aa
  • 氨基酸序列
    MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
  • 基因功能参考文献：
    1. that Capn4 promotes cell proliferation by increasing MAPK7 expression PMID: 29331389
    2. Calpain small subunit 1 (Capn4) overexpression increased the protein level of cleaved talin and and activated the focal adhesion kinase (FAK)/AKT/MAPK signaling in 786-O cells, while Capn4 silencing decreased the protein level of cleaved talin in Caki-1 cells. PMID: 29648579
    3. Capn4 and miR-1271 may serve as potential therapeutic targets for the treatment of colorectal cancer. PMID: 29331762
    4. MALAT1 and Capn4 were up-regulated while miR-124 expression was down-regulated in nasopharyngeal carcinoma cell lines. PMID: 28857668
    5. Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/beta-catenin pathway. PMID: 27878263
    6. CAPNS1 depletion is coupled to impairment of breast cancer cell growth. PMID: 26771715
    7. High levels of Capn4 expression were associated with lymph node metastasis and large tumor size in non-small cell lung cancer patients.Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2. PMID: 25636510
    8. HBXIP was able to up-regulate Capn4 at the levels of promoter. PMID: 25304384
    9. The overexpression of Capn4 is a novel negative prognostic marker, and Capn4 may be used as a new target in therapeutic strategies for human glioma. PMID: 24628706
    10. Capn4 can contribute to hepatocellular carcinoma growth and metastasis PMID: 24962955
    11. Capn4 mRNA and protein are increased in human clear cell renal cell carcinoma tissues and higher Capn4 levels are associated with advanced clinical tumour stage and shorter overall survival. PMID: 24514433
    12. Capn4 upregulated MMP2 via nuclear factor-kappaB activation, manifested by increased phosphorylation of p65, a subunit of NF-kappaB. PMID: 24703594
    13. This study suggests that augmented calpain activity is associated with increased incidence of thrombosis under hypoxic environments. PMID: 24297866
    14. Capn4 overexpression was implicated in ICC metastasis/invasion, and Capn4 overexpression may be used as a molecular therapeutic target for intrahepatic cholangiocarcinoma PMID: 23349941
    15. The s conclude that hepatitis B virus X protein upregulate Capn4 through NF-kappaB/p65 to promote migration of hepatoma cells. PMID: 20419804
    16. CAPNS1 depletion is coupled to reduced levels of H2AX phosphorylation, not only in Ras(v12) induced BJ-ET fibroblasts, but also in a number of cellular systems upon genotoxic stress PMID: 20107320
    17. Genetic variations in LEP, CAPNS1 and ALOX15 show significant association with IL-6 expression. PMID: 19942621
    18. calpain-mediated XIAP degradation contributes to initiation of apoptosis in normal neutrophils and dysfunction of this regulatory pathway can lead to pathological neutrophil accumulation. PMID: 12121983
    19. Whereas alphaPIX guanine nucleotide exchange factor activity contributes to enhanced formation of cellular protrusions, the GEF-independent association with calpain 4 leads to induction of a yet unknown signaling cascade resulting in cell spreading. PMID: 15611136
    20. results reveal that especially NRF-1, along with AP-1 and, to a minor extent, an Sp1 site, is essential for human CAPNS1 promoter activity and gene expression PMID: 18234454
    21. c-Myc regulates calpain activity through calpastatin; apoptosis induced by calpain inhibition is dependent on c-Myc, and calpastatin knockdown promotes transformation in c-Myc-negative cells PMID: 18544539
    22. RasGAP and Capns1 interaction in oncogenic Ras cells is involved in regulating migration and cell survival. PMID: 18761085

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  • 亚细胞定位：
    Cytoplasm. Cell membrane.
  • 数据库链接：

    HGNC: 1481

    OMIM: 114170

    KEGG: hsa:826

    STRING: 9606.ENSP00000246533

    UniGene: Hs.515371