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  4. Recombinant Human Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (NOS1AP)

Recombinant Human Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (NOS1AP)

  • 货号：
    CSB-YP015942HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015942HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015942HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015942HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015942HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NOS1AP
  • Uniprot No.：
  • 别名：
    6330408P19Rik; C terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON); C terminal PDZ domain ligand of neuronal nitric oxide synthase; C terminal PDZ ligand of neuronal nitric oxide synthase protein; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; CAPON; CAPON_HUMAN; Carboxyl terminal PDZ ligand of neuronal nitric oxide synthase protein; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Ligand of neuronal nitric oxide synthase with carboxyl terminal PDZ domain; MGC138500; Nitric oxide synthase 1 (neuronal) adaptor protein; Nitric oxide synthase 1 adaptor protein; Nos1ap
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-506
  • 氨基酸序列
    MPSKTKYNLV DDGHDLRIPL HNEDAFQHGI CFEAKYVGSL DVPRPNSRVE IVAAMRRIRY EFKAKNIKKK KVSIMVSVDG VKVILKKKKK LLLLQKKEWT WDESKMLVMQ DPIYRIFYVS HDSQDLKIFS YIARDGASNI FRCNVFKSKK KSQAMRIVRT VGQAFEVCHK LSLQHTQQNA DGQEDGESER NSNSSGDPGR QLTGAERAST ATAEETDIDA VEVPLPGNDV LEFSRGVTDL DAVGKEGGSH TGSKVSHPQE PMLTASPRML LPSSSSKPPG LGTETPLSTH HQMQLLQQLL QQQQQQTQVA VAQVHLLKDQ LAAEAAARLE AQARVHQLLL QNKDMLQHIS LLVKQVQELE LKLSGQNAMG SQDSLLEITF RSGALPVLCD PTTPKPEDLH SPPLGAGLAD FAHPAGSPLG RRDCLVKLEC FRFLPPEDTP PPAQGEALLG GLELIKFRES GIASEYESNT DESEERDSWS QEELPRLLNV LQRQELGDGL DDEIAV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4.
  • 基因功能参考文献：
    1. Findings showed that NOS1AP (rs348624, rs12742393 and rs1415263), DISC1 (rs821633 and rs1000731), DAOA (rs2391191) and GSK3B (rs6438552) SNPs had no association with development of early-onset schizophrenia; however, our finding suggested statistically significant role of the interaction of NOS1AP, DISC1, DAOA and GSK3B polymorphisms in schizophrenia susceptibility. PMID: 29100974
    2. Novel Hispanic/Latino-specific Single Nucleotide Polymorphism at NOS1AP implicate gene regulatory dysfunction in QT prolongation. PMID: 27988371
    3. If the expression of Capon is decreased, myeloma cells are adhered to fibronectin or bone marrow stromal cells (bone marrow mesenchymal stem cells). In addition, the sensitivity of the cell line to chemotherapeutic agents was reduced after silencing Capon in the myeloma cell line which was adhered to bone marrow mesenchymal stem cells. PMID: 28671047
    4. sex was identified as a moderator of the association between NOS1AP sequence variants and QTc prolongation in two long QT syndrome founder populations PMID: 28720088
    5. Association between NOS1AP and PTSD severity, depression, anxiety, and stress was found. NOS1AP was associated with resilience. PMID: 28465168
    6. gender modulated the interaction between NOS1AP promoter DNA methylation in intracranial aneurysm and brain arteriovenous malformation BAVM patients PMID: 27080431
    7. results hint towards an involvement of NOS-I/NOS1AP interaction in the regulation of dendritic spine plasticity PMID: 26861996
    8. Results from genome-wide DNA methylation, functional network analysis and pyrosequencing, show selective CpG sites (NOS1AP, BID, and GABRB1) differentially methylated in smokers and chronic obstructive pulmonary disease patients compared to nonsmokers. PMID: 28416970
    9. Data indicate that overexpression of nitric oxide synthase 1 adaptor protein short form (CAPON-S) led to the inactivation of the proto-oncogene protein Akt (Akt) signaling pathway. PMID: 27869735
    10. SNPs in the NOS1AP gene influence QTc interval duration but we have not demonstrated a direct association with the risk of sudden cardiac death PMID: 26332198
    11. Results suggest that NOS1AP variants are associated with various forms of depression in schizophrenia and are more prevalent in males. PMID: 26384012
    12. The study suggested that rs3751284 and rs348624 in the NOS1AP gene might be susceptibility loci for sudden unexplained death during daily activities. PMID: 25639344
    13. report of the association of common NOS1AP polymorphisms with sudden unexplained nocturnal death syndrome in the southern Chinese Han population. These findings suggest that the A allele of rs12567209 and haplotype GCTA may serve as a protective modifier. PMID: 24504561
    14. The A allele of rs12567209 in NOS1AP may serve as an independent predictor of all-cause death and SCD in patients with CHF. PMID: 24418727
    15. This study suggested that NOS1 and NOS1AP were associated with schizophrenia. PMID: 24220657
    16. We further localized NOS1AP to cardiomyocyte intercalated discs (IDs) and demonstrate that overexpression of NOS1AP in cardiomyocytes leads to altered cellular electrophysiology. PMID: 24857694
    17. This is the first study reporting that a variant of the NOS1AP gene is associated with PTSD. Our data also suggest that a genetic variant in NOS1AP may increase the susceptibility to severe depression in patients with PTSD and increased risk for suicide. PMID: 23146198
    18. rs10918859 of the NOS1AP gene is associated with CHD in Han Chinese. In addition, here we report a gender effect in the association between rs10918859 of the NOS1AP gene and CHD. PMID: 23171141
    19. In atherosclerosis, NOS1AP variants were associated with QT in CAU, with weaker evidence for selected variants in HIS and CHN. Location of significant SNPs varied across ancestry. PMID: 23347024
    20. Decreased NOS1AP expression in rs10494366 TT and rs10918594 CC homozygotes may underlie shorter repolarization times.Myocardial tissue for gene expression analysis was obtained from extracted cardiac implantable electronic device. PMID: 22019493
    21. Common variations in the NOS1AP gene are associated with a significant increase in the risk of drug-induced long QT syndrome. PMID: 22682551
    22. NOS1AP colocalizes with both SCRIB and VANGL1 along cellular protrusions in metastatic breast cancer cells, but does not colocalize with either SCRIB or VANGL1 at cell junctions in normal breast cells PMID: 22179838
    23. Common variations in or near CASQ2, GPD1L, and NOS1AP are associated with increased risk of sudden cardiac death in patients with coronary artery disease PMID: 21685173
    24. NOS1AP rs203462 polymorphisms did not correlate with an increased risk of QT interval prolongation among kidney recipients. PMID: 21996201
    25. relationship of nitric oxide synthase 1 adaptor protein (NOS1AP) polymorphism with serum creatinine level and occurrence of delayed graft function in kidney transplant recipients PMID: 21959512
    26. Data show that NOS1AP protein levels are altered in BA46 and cerebellum of patients with schizophrenia. PMID: 20605702
    27. The genetic variant rs12143842 in NOS1AP is associated with QT interval duration in a Chinese population with Type 2 diabetes. PMID: 20722683
    28. NOS1AP has a modest effect on ECG t-wave peak to t-wave end interval but is not related to T-wave morphology measures. PMID: 20215044
    29. the NOS1AP variant is associated with incidence of type 2 diabetes in calcium channel blocker users PMID: 19943157
    30. Two non-synonymous NOS1AP variations, V37I and D423N were identified in two families, one with two siblings with Obsessive-Compulsive Disorder and the other with two brothers with autism spectrum disorders. PMID: 20602773
    31. NOS1AP tag SNP genotype may provide an additional clinical dimension, which helps assess risk and choice of therapeutic strategies in LQTS. PMID: 20538168
    32. NOS1AP variants may not play a dominant role in susceptibility to type 2 diabetes, but a minor effect cannot be excluded. PMID: 19937226
    33. The length of QT interval verify the importance of NOS1AP protein and to identify a SNP on chromosome 13 reaching genome-wide significance. PMID: 20031603
    34. Study provided additional evidence for association between genetic variation within NOS1AP and SCD. PMID: 19643915
    35. these findings support the hypothesis that NOS1 redistribution in injured myocardium requires the formation of a complex with the PDZ adaptor protein CAPON. PMID: 19800018
    36. Sequence analysis revealed that one non-synonymous substitution in exon 8 was observed in one subject, in addition to six SNPs in exons and introns. This study showed variations in NOS1AP might be involved in occurrence of SIDS PMID: 19289301
    37. Our findings indicate that CAPON gene may be a candidate susceptibility gene for schizophrenia in Chinese Han population, and also provide further support for the importance of NMDAR-mediated glutamatergic transmission in the etiology of schizophrenia. PMID: 15707951
    38. study adds support to a role of CAPON in schizophrenia, produces new evidence implicating this gene in the etiology of bipolar disorder, and suggests a possible mechanism of action of CAPON in psychiatric illness PMID: 16146415
    39. The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations. PMID: 16202394
    40. This genome-wide study identified NOS1AP (CAPON), a regulator of neuronal nitric oxide synthase, as a new target that modulates cardiac repolarization PMID: 16648850
    41. NOS1AP variants influence QT interval PMID: 17565224
    42. Strong effects of NOS1AP variants in diabetic individuals suggest that this patient subset may be particularly susceptible to genetic variants that influence myocardial depolarization and repolarization as manifest in the QT interval. PMID: 18235038
    43. provide a rationale for the association of CAPON gene variants with extremes of the QT interval in human populations PMID: 18337493
    44. Our results identified no single marker nor haplotype associated with schizophrenia, which did not suggest that CAPON was a susceptible site in the Chinese Han population. PMID: 18430503
    45. Linkage and association studies from multiple samples drawn from different populations indicate that a schizophrenia susceptibility gene is located in the region of chromosome 1 containing NOS1AP. PMID: 18474209
    46. Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea. PMID: 18551039
    47. Single nucleotide polymorphisms are associated with incidence of diabetes mellitus in people who use calcium channel blockers. PMID: 18766325
    48. Demonstrated that the common NOS1AP variant rs10494366 was associated with increased QT interval in healthy young adults. PMID: 18785031
    49. A common variant (rs10494366T > G) within NOS1AP gene was associated with QT-interval duration. PMID: 18927126
    50. study found significant association between eight SNPs in the NOS1AP gene region to schizophrenia (patients from a South American population isolate) and its clinical dimensions PMID: 19077434

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  • 数据库链接：

    HGNC: 16859

    OMIM: 605551

    KEGG: hsa:9722

    STRING: 9606.ENSP00000355133

    UniGene: Hs.731942