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  4. Recombinant Human Cellular retinoic acid-binding protein 2 (CRABP2)

Recombinant Human Cellular retinoic acid-binding protein 2 (CRABP2)

  • 货号：
    CSB-YP005936HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005936HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005936HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005936HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005936HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CRABP2
  • Uniprot No.：
  • 别名：
    Cellular retinoic acid binding protein 2; Cellular retinoic acid binding protein II; Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP II; CRABP-II; Crabp2; CRABPII; RABP2_HUMAN; RBP6; Rretinoic acid-binding protein, cellular, type II
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-138
  • 氨基酸序列
    MPNFSGNWKI IRSENFEELL KVLGVNVMLR KIAVAAASKP AVEIKQEGDT FYIKTSTTVR TTEINFKVGE EFEEQTVDGR PCKSLVKWES ENKMVCEQKL LKGEGPKTSW TRELTNDGEL ILTMTADDVV CTRVYVRE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
  • 基因功能参考文献：
    1. Semiquantitative and quantitative analyses of the markers RARA and CRABP2 indicate their potential as biomarkers for tumor progression and their participation in nephroblastoma tumorigenesis PMID: 29378601
    2. These data suggest a retinoic acid-independent, non-tumor suppressor role of CRABP2 for the survival of Malignant peripheral nerve sheath tumor (MPNST) cells in vitro. Targeting CRABP2 overexpression may represent a unique approach for the treatment of human MPNST. PMID: 28502478
    3. A high expression ratio between FABP5 and CRABPII may be related to CP tumor recurrence and ATRA could be a potential therapeutic agent for CP chemotherapy. PMID: 27418530
    4. reducing CRABP2 levels may enhance the therapeutic index of Retinoic acid in glioblastoma multiforme patients PMID: 26893190
    5. in esophageal squamous carcinogenesis by significantly inhibiting cell growth, inducing cell apoptosis and blocking cell metastasis both in vitro and in vivo PMID: 26839961
    6. The anticarcinogenic activities of CRABP2 are mediated by both HuR and RAR. PMID: 25320093
    7. CBX3 and CRABP2 expression was markedly increased in lung cancer tissues PMID: 24751108
    8. Reengineering of cellular retinoic acid binding protein II (CRABPII) to be capable of binding retinal as a protonated Schiff base is described PMID: 24059243
    9. CRABP2 controls mRNA stabilization by HuR. PMID: 24687854
    10. overexpression of CRABP-II is a late event of pancreatic carcinogenesis, and it could be used as a diagnostic marker PMID: 24709110
    11. all three proteins (RDH10, RALDH2, and CRABP2) appeared to be required for ATRA production induced by activation of PPARgamma PMID: 23833249
    12. E-FABP showed high exp ression in NSCLC, and the increased E-FABP expression may involved in the occurrence and development of NSCLC PMID: 23327868
    13. Hypermethylation in the CpG island of the CRABP2 gene is associated with astrocytic gliomas. PMID: 22275178
    14. Aberrant methylation in CRABP-II reduces the expression of CRABP-II that in turn confers retinoic acid resistance in medulloblastoma cells. PMID: 22153617
    15. Low CRABP2 is associated with pancreatic ductal adenocarcinoma. PMID: 22010213
    16. Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation PMID: 21998312
    17. Trophoblast spheroids cocultured with endometrial cells overexpressing CRABP2 are defective in expansion and exhibit apoptosis, suggesting that CRABP2 is involved in abnormal endometrium-trophoblast interaction, leading to implantation failure. PMID: 21605859
    18. Data show that NIPER-4 induces cIAP1-mediated ubiquitylation of CRABP-II, resulting in the proteasomal degradation. PMID: 21414315
    19. Individual variation in ALDH1A2/CRABP2 genes may account for subtle variations in retinoic acid-dependent human embryogenesis. PMID: 20308937
    20. Data sghow a higher frequency of CRABP2 and MX1 hypermethylation in primary HNSCC when compared with lymphocytes from healthy individuals. PMID: 20019841
    21. Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest. PMID: 11909957
    22. Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of this protein PMID: 12482873
    23. In this study, we excluded mutations within the complete coding region and the promoter of LMNA and the CRABP II gene in HIV-1 infected patients with lipodystrophy PMID: 12844477
    24. CRABP-II has a role in wound re-epithelialisation by dermal fibroblasts PMID: 14766225
    25. Phosphorylation/dephosphorylation of retinoic x receptor alpha via protein kinase C may be involved in the regulation of CRABP-II gene expression. PMID: 15225641
    26. Data suggest that the ligand-controlled nuclear localization signal of CRABP-II may represent a general mechanism for posttranslational regulation of the subcellular distribution of a protein. PMID: 15866176
    27. Transient transfection of either all-trans-retinoic acid (ATRA) receptor alpha or estrogen receptor alpha expression vectors increased CRABPII expression in MDA-MB-231 cells PMID: 15870697
    28. CRABP-II overexpression in CAKI-2 RCC cells did not significantly influence RA associated antiproliferative actions. PMID: 16215318
    29. MycN binds to the promoter of CRABP-II and induces CRABP-II transcription directly in neuroblastoma. PMID: 16912187
    30. Results describe the structure of apo-wild type (WT) CRABPII at 1.35 A and show that apo- and holo-CRABPII share very similar structures. PMID: 16979656
    31. AP2 factors regulate CRABPII expression in human mammary epithelial cells and breast cancer cells PMID: 17187826
    32. results show that the CRABP2 gene is associated with increased plasma LDL-C concentrations. Carriers of the C allele had significantly higher LDL-C in healthy males, HIV-infected patients, and patients with familial hypercholesterolemia PMID: 17484622
    33. Retinoic acid and retinol regulate expression of cellular retinol binding protein 1 and cellular RA binding protein 2 in fibroid and myometrial cells. PMID: 18343808
    34. MycN and DNA methylation are responsible for CRABP-II expression in pediatric tumors and demethylation of CRABP-II may be an early event in tumor development. PMID: 18955045
    35. Derangement/lack of a critical factor necessary for RARalpha function induces epigenetic repression of a RA-regulated gene network downstream of RARalpha, with major pleiotropic biological outcomes. PMID: 19173001

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  • 亚细胞定位：
    Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 数据库链接：

    HGNC: 2339

    OMIM: 180231

    KEGG: hsa:1382

    STRING: 9606.ENSP00000357204

    UniGene: Hs.405662