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  4. Recombinant Human Centrosomal protein POC5 (POC5)

Recombinant Human Centrosomal protein POC5 (POC5)

  • 中文名称：
    人POC5重组蛋白
  • 货号：
    CSB-YP843309HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人POC5重组蛋白
  • 货号：
    CSB-EP843309HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人POC5重组蛋白
  • 货号：
    CSB-EP843309HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人POC5重组蛋白
  • 货号：
    CSB-BP843309HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人POC5重组蛋白
  • 货号：
    CSB-MP843309HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    POC5
  • Uniprot No.：
  • 别名：
    C5orf37; Centrosomal protein POC5; FLJ35779; hPOC5; MGC120442; MGC120443; MGC120444; OTTHUMP00000222116; OTTHUMP00000222453; Poc5; POC5 centriolar protein; POC5 centriolar protein homolog (Chlamydomonas); POC5 centriolar protein homolog; POC5_HUMAN; Protein of centriole 5; Proteome of centriole 5
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-575
  • 氨基酸序列
    MSSDEEKYSL PVVQNDSSRG SSVSSNLQEE YEELLHYAIV TPNIEPCASQ SSHPKGELVP DVRISTIHDI LHSQGNNSEV RETAIEVGKG CDFHISSHSK TDESSPVLSP RKPSHPVMDF FSSHLLADSS SPATNSSHTD AHEILVSDFL VSDENLQKME NVLDLWSSGL KTNIISELSK WRLNFIDWHR MEMRKEKEKH AAHLKQLCNQ INELKELQKT FEISIGRKDE VISSLSHAIG KQKEKIELMR TFFHWRIGHV RARQDVYEGK LADQYYQRTL LKKVWKVWRS VVQKQWKDVV ERACQARAEE VCIQISNDYE AKVAMLSGAL ENAKAEIQRM QHEKEHFEDS MKKAFMRGVC ALNLEAMTIF QNRNDAGIDS TNNKKEEYGP GVQGKEHSAH LDPSAPPMPL PVTSPLLPSP PAAVGGASAT AVPSAASMTS TRAASASSVH VPVSALGAGS AATAASEEMY VPRVVTSAQQ KAGRTITARI TGRCDFASKN RISSSLAIMG VSPPMSSVVV EKHHPVTVQT IPQATAAKYP RTIHPESSTS ASRSLGTRSA HTQSLTSVHS IKVVD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential for the assembly of the distal half of centrioles, required for centriole elongation.
  • 基因功能参考文献：
    1. Common variant rs6892146 of POC5 is associated with the development of adolescent idiopathic scoliosis in the Chinese population. PMID: 29189569
    2. Depletion of CEP295 blocks the incorporation of POC5 and POC1B into the distal portion of centrioles and suppresses the post-translational modification of centriolar microtubules . Our study thus uncovers a new role for CEP295 during centriole elongation. PMID: 27185865
    3. Mutations in the POC5 gene contribute to the occurrence of idiopathic scoliosis. PMID: 25642776
    4. Data indicate that overexpression of the centrin interactor POC5 leads to the assembly of linear, centrin-dependent structures. PMID: 23844208
    5. hPOC5, a conserved centrin-binding protein that contains Sfi1p-like repeats is characterized. PMID: 19349582

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to the distal portion of centrioles.
  • 蛋白家族：
    POC5 family
  • 数据库链接：

    HGNC: 26658

    OMIM: 617880

    KEGG: hsa:134359

    STRING: 9606.ENSP00000410216

    UniGene: Hs.432726