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  4. Recombinant Human Cholecystokinin (CCK), partial

Recombinant Human Cholecystokinin (CCK), partial

  • 货号：
    CSB-YP004771HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP004771HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP004771HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP004771HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP004771HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CCK
  • Uniprot No.：
  • 别名：
    (1-49)-CCK58; CCK; CCK12; CCK18; CCK25; CCK33; CCK39; CCK5; CCK58; CCK7; CCK8; CCKN_HUMAN; Cholecystokinin-5
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 表达区域：
    46-103aa
  • 氨基酸序列
    VSQRTDGESRAHLGALLARYIQQARKAPSGRMSIVKNLQNLDPSHRISDRDYMGWMDF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
  • 基因功能参考文献：
    1. We found the suicide-associated gene coexpression network. The reconstructed network consisted of 104 genes. Topological analysis showed that in total, CCK, INPP1, DDC, and NPY genes are the most fundamental hubs in the network PMID: 29381655
    2. L-trp is a luminal regulator of CCK release with effects on gastric emptying, an effect that could be mediated by CCK. L-trp's effect on GLP-1 secretion is only minor. At the doses given, the two amino acids did not affect subjective appetite feelings. PMID: 27875537
    3. The CCK polymorphism have reported significant association of -45C>T polymorphism with the presence of hallucinations. PMID: 27084212
    4. CCK does not appear to play a unique independent role in satiety/satiation. PMID: 26429068
    5. CCK release has been found to be halved in pregnant women with hyperemesis gravidarium, which supports the hypothesis that gastrointestinal motility is increased in pregnant women with hyperemesis gravidarium. PMID: 25331205
    6. CCK in plasma is an independent marker of cardiovascular mortality in elderly female patients. PMID: 26878472
    7. These data offer preliminary evidence supporting an association between the rs1799923 polymorphism in the CCK gene and PTSD PMID: 26454231
    8. Data suggest that endocrine responses differ between jejunal and gastric enteral feeding, with higher peak plasma CCK (cholecystokinin), PYY (peptide YY), and GLP-1/2 (glucagon-like peptides 1/2) concentrations being attained after jejunal feeding. PMID: 26762368
    9. active GLP-1 produced in the islet stimulates cholecystokinin production and secretion in a paracrine manner via cyclic AMP and CREB. PMID: 25984632
    10. Cardiac expression of pro-cholecystokinin is cell-specific, which differentiates the expression from that of intestinal endocrine cells and cerebral neurons. Plasma Pro-CCK is a prognostic marker in patients with stable heart failure. PMID: 25627687
    11. CCK binding modulates the contractile function of the lower esophageal sphincter through differential binding to the CCK-A receptor on the sling and clasp fibers PMID: 24914377
    12. Data suggest that up-regulation of plasma CCK levels is 50% higher following breakfast of meal replacement beverage containing fat emulsion of rapeseed oil with droplet size of 0.1 um (versus 0.3 um); satiety response and food intake are unaffected. PMID: 23975326
    13. These studies identify a key role for Cck in the development and treatment of mania. PMID: 23399917
    14. Results suggest excessive local release of CCK in response to duodenal lipid in functional dyspepsia. PMID: 24252886
    15. CCK enhances cholesterol absorption by activation of a pathway involving CCK1R/CCK2R, Gbetagamma, PI3K, Akt, Rab11a, and NPC1L. PMID: 24692543
    16. This review will summarize what is known regarding CCK, its receptors, and pancreatic--{REVIEW} PMID: 24177032
    17. We aimed to determine whether fasting or meal-stimulated ghrelin, PYY, CCK, and satiety responses are different between lean PCOS patients and healthy women. PMID: 24001751
    18. hnRNP-K regulates extracellular matrix, cell motility, and angiogenesis pathways. Involvement of the selected genes (Cck, Mmp-3, Ptgs2, and Ctgf) and pathways was validated by gene-specific expression analysis PMID: 23564449
    19. Normal CCK profiles in AN at admission indicates hormonal responses adapted to low food intake while change of eating habits and weight gain PMID: 23349895
    20. CD36 is a major mediator of FA-induced release of CCK and secretin. These peptides contribute to the role of CD36 in fat absorption and to its pleiotropic metabolic effects. PMID: 23233532
    21. a lineage of mature enteroendocrine cells have the ability to coexpress members of a group of functionally related peptides: CCK, secretin, GIP, GLP-1, PYY, and neurotensin PMID: 23064014
    22. CCK remarkably increases the firing frequency of action potentials of layer III pyramidal neurons in the entorhinal cortex. PMID: 21753024
    23. CCK gene -45C/T locus T allele was positively associated with schizophrenia in female Han population in northern China. PMID: 21542221
    24. it is likely that unsulfated CCK peptides constitute a separate hormone system that acts via CCK-B receptors. [review] PMID: 21985915
    25. This article reviews the role of cholecystokinin (CCK), a satiety-producing hormone, in the regulation of binge eating in those who suffer from bulimia nervosa [review] PMID: 22188045
    26. The results of this study demonistrated that the cholecystokinin polymorphisms is related toin Parkinson's disease hallucinations in asian group. PMID: 21506165
    27. CCK modulates intrinsic neuronal excitability and synaptic transmission in a surprisingly cell-type specific manner, acting as a key molecular switch to regulate the functional output of neuronal circuits. PMID: 21154912
    28. Cholecystokinin gene polymorphisms are not associated with antipsychotic induced weight gain in schizophrenia patients. PMID: 20732371
    29. Neither treatment of pancreatic cancer cells with CCK antibodies nor the down-regulation of CCK mRNA and peptide by shRNAs altered growth in vitro or in vivo. PMID: 21186400
    30. These results point to a potential route of action by which components of Hoodia might influence appetite control; the natural taste receptor antagonist was identified for further studies as an appetite suppressant. PMID: 20930049
    31. Study compared CCK-like immunoreactivity (CCK-LI) in plasma from 25 subjects in the late luteal phase (LLP) and the follicular phase (FP) and found that there was no difference during the menstrual cycle PMID: 20457200
    32. results suggest that the CCK system may play a role in the pathogenesis of panic disorder, with susceptibility alleles both protecting and contributing to the disease PMID: 20023595
    33. REVIEW: role in thermoregulation and other aspects of energetics PMID: 20036221
    34. Cefaclor, when given before a meal in the form of a capsule, does not stimulate CCK release or slow gastric emptying in healthy humans. PMID: 19914303
    35. This article reviews the corpus of work supporting the role of CCK in anxiety and suggests three research approaches which can further enhance our understanding of the CCK-2 system in panic disorder. PMID: 11713976
    36. This review describes the signaling pathways and transcription factors involved in neuronal CCK gene transcription. PMID: 11713982
    37. Endoproteolytic processing events of heterologously expressed cholecystokinin are studied in Saccharomyces cerevisiae. PMID: 11713985
    38. mapping of the CCK1R binding site by identifying residues that interact with the methionine and phenylalanine residues of the C-terminal moiety of CCK PMID: 11724786
    39. Deteriorating gallbladder contractions, possibly induced by alterations in the CCK-AR gene, as well as CCK-AR gene polymorphism, promoted gallstone formation. PMID: 12572876
    40. Results suggest that the L-(-188G) haplotype may act as a protective factor against panic by reducing the expression of anxiogenic cholecystokinin (CCK). PMID: 12627463
    41. in Chinese, visual hallucinations in Parkinson's disease are associated with cholecystokinin -45C>T polymorphism, and this association was still observed in the presence of the cholecystokinin-A receptor TC/CC genotype PMID: 12777967
    42. reduced basal hunger, rather than increased meal-induced satiety, contributes to the anorexia of aging and that changes in cholecystokinin are unlikely to be responsible PMID: 12915664
    43. CCK's suppression of food intake is enhanced when the stomach is distended. PMID: 12920059
    44. Ingestion of a CCK-releasing fatty acid reduces the tolerated volume of liquid delivered into the stomach, primarily via a CCK(1) receptor-mediated delay in gastric emptying. PMID: 14764444
    45. Review summarizes the physiological role of CCK not only in the stimulation of pancreatic and biliary secretions but also in the regulation of gastrointestinal motility. PMID: 15100163
    46. Study based on a small, well-characterized matched case-control group of patients with Parkinson disease (PD) suggests that the cholecystokinin system may influence the development of hallucinations in PD subjects. PMID: 15313848
    47. Ewing sarcomas synthesize and secrete proCCK that can be identified in plasma as circulating tumor marker. PMID: 15328192
    48. CCK regulates pancreatic enzyme secretion and growth, intestinal motility, satiety signalling and the inhibition of gastric acid secretion--REVIEW PMID: 15533776
    49. conclude that women with polycystic ovary syndrome (PCOS) have reduced postprandial cholecystokinin(CCK) secretion and deranged appetite regulation associated with increased levels of testosterone PMID: 15624269
    50. Gastrin and CCK exert a trophic action on some of the biliary tract cancers. PMID: 15682471

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Gastrin/cholecystokinin family
  • 数据库链接：

    HGNC: 1569

    OMIM: 118440

    KEGG: hsa:885

    STRING: 9606.ENSP00000335657

    UniGene: Hs.458426