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  4. Recombinant Human Choline transporter-like protein 1 (SLC44A1), partial

Recombinant Human Choline transporter-like protein 1 (SLC44A1), partial

  • 货号：
    CSB-YP819903HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP819903HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP819903HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP819903HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP819903HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC44A1
  • Uniprot No.：
  • 别名：
    CD 92; CD92; CD92 antigen; CD92 protein; CDW 92; CDw92; CDW92 antigen; Choline transporter like protein 1; Choline transporter-like protein 1; CHTL 1; CHTL1; CTL 1; CTL1; CTL1_HUMAN; RP11 287A8.1; slc44a1; Solute carrier family 44 member 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Choline transporter. Involved in membrane synthesis and myelin production.
  • 基因功能参考文献：
    1. SLC44A1 and KLF13 may be involved in tumorigenesis and the metastasis of colon cancer by miRNA regulation PMID: 29408621
    2. The differential expression pattern of CTL1 and CTL2 suggests that CTL1 is the key transporter involved in choline transport from maternal circulation and both transporters are likely involved in stromal and endothelial cell choline transport. PMID: 26601765
    3. This study showed that SLC44A1-PRKCA fusion seems to be a specific characteristic of Papillary glioneuronal tumors with a high diagnostic value. PMID: 26671581
    4. Reduced CTL1 expression is associated with postural orthostatic tachycardia syndrome. PMID: 25466896
    5. NCI-H69 cells express the choline transporter CTL1 which uses a directed H(+) gradient as a driving force, and its transport functions in co-operation with NHE1. PMID: 23948665
    6. REVIEW highlights discovery and characterization of SLC44A1, describes its expression patterns and subcellular localization and summarizes evidence for the role of this choline transporter in the central nervous system. PMID: 22483272
    7. CTL1 is expressed in both SH-SY5Y and LA-N-2 cells and is responsible for choline uptake that relies on a directed hydrogen ion gradient as a driving force. PMID: 21185344
    8. In conclusion, choline transport in A549 cells is increased by treatment with DEX, and the increase is mediated by induction of functional choline transporters CTL1 and CTL2. PMID: 20410607
    9. This study provides the first example of CHT1 expression in neurons which do not use acetylcholine as neurotransmitter. PMID: 15691711
    10. Data suggest that an impaired choline transporter-like protein-1 trafficking is the key contributing factor to reduced choline uptake, subsequent to the PMA-induced THP-1 differentiation to macrophages. PMID: 16319125
    11. characterization the 5'-flanking region of the human (h)CTL1 gene and some of the possible mechanisms of its regulation, including promoter activity, splicing, and expression PMID: 16609143
    12. SLC44A1 mRNA and protein expression were down-regulated during choline deficiency. PMID: 19357133
    13. The presence of CTL1 protein in rat and human CNS regions, where it is found in neuronal, glial and endothelial cells, suggests that malfunction of this transporter could have important implications in nervous system development and repair. PMID: 19519661

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein.
  • 蛋白家族：
    CTL (choline transporter-like) family
  • 组织特异性：
    Expressed in various cells of the hematopoietic system.
  • 数据库链接：

    HGNC: 18798

    OMIM: 606105

    KEGG: hsa:23446

    STRING: 9606.ENSP00000363852

    UniGene: Hs.573495