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  4. Recombinant Human Coiled-coil domain-containing protein 106 (CCDC106)

Recombinant Human Coiled-coil domain-containing protein 106 (CCDC106)

  • 货号：
    CSB-YP863135HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP863135HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP863135HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP863135HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP863135HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CCDC106
  • Uniprot No.：
  • 别名：
    CC106_HUMAN; Ccdc106; Coiled-coil domain-containing protein 106; HSU79303; Protein predicted by clone 23882; ZNF581
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-280
  • 氨基酸序列
    MNDRSSRRRT MKDDETFEIS IPFDEAPHLD PQIFYSLSPS RRNFEEPPEA ASSALALMNS VKTQLHMALE RNSWLQKRIE DLEEERDFLR CQLDKFISSA RMEAEDHCRM KPGPRRMEGD SRGGAGGEAS DPESAASSLS GASEEGSASE RRRQKQKGGA SRRRFGKPKA RERQRVKDAD GVLCRYKKIL GTFQKLKSMS RAFEHHRVDR NTVALTTPIA ELLIVAPEKL AEVGEFDPSK ERLLEYSRRC FLALDDETLK KVQALKKSKL LLPITYRFKR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
  • 基因功能参考文献：
    1. Our studies revealed that CCDC106 is associated with non-small cell lung cancer progression and unfavorable prognosis. CCDC106 enhanced Cyclin A2 and Cyclin B1 expression and promoted A549 and H1299 cell proliferation, which depended on AKT signaling. These results suggest that CCDC106 may be a novel target for lung cancer treatment. PMID: 28460455
    2. CCDC106 promotes the degradation of p53 protein and inhibits its transactivity. PMID: 20159018
  • 亚细胞定位：
    Nucleus. Note=Colocalizes with p53/TP53.
  • 数据库链接：

    HGNC: 30181

    OMIM: 613478

    KEGG: hsa:29903

    UniGene: Hs.82482