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  4. Recombinant Human Coiled-coil domain-containing protein 11 (CCDC11)

Recombinant Human Coiled-coil domain-containing protein 11 (CCDC11)

  • 中文名称：
    Recombinant Human Coiled-coil domain-containing protein 11(CCDC11),Yeast
  • 货号：
    CSB-YP856981HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Coiled-coil domain-containing protein 11(CCDC11),Yeast
  • 货号：
    CSB-EP856981HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Coiled-coil domain-containing protein 11(CCDC11),Yeast
  • 货号：
    CSB-EP856981HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Coiled-coil domain-containing protein 11(CCDC11),Yeast
  • 货号：
    CSB-BP856981HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Coiled-coil domain-containing protein 11(CCDC11),Yeast
  • 货号：
    CSB-MP856981HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CFAP53
  • Uniprot No.：
  • 别名：
    4933415I03Rik; CCD11_HUMAN; CCDC11; Cilia and flagella associated protein 53; Coiled coil domain containing 11; Coiled coil domain containing protein 11; Coiled-coil domain-containing protein 11; FLJ32743; HTX6; MGC117752; RGD1306734
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-514
  • 氨基酸序列
    MYSQRFGTVQ REVKGPTPKV VIVRSKPPKG QGAEHHLERI RRSHQKHNAI LASIKSSERD RLKAEWDQHN DCKILDSLVR ARIKDAVQGF IINIEERRNK LRELLALEEN EYFTEMQLKK ETIEEKKDRM REKTKLLKEK NEKERQDFVA EKLDQQFRER CEELRVELLS IHQKKVCEER KAQIAFNEEL SRQKLVEEQM FSKLWEEDRL AKEKREAQEA RRQKELMENT RLGLNAQITS IKAQRQATQL LKEEEARLVE SNNAQIKHEN EQDMLKKQKA KQETRTILQK ALQERIEHIQ QEYRDEQDLN MKLVQRALQD LQEEADKKKQ KREDMIREQK IYHKYLAQRR EEEKAQEKEF DRILEEDKAK KLAEKDKELR LEKEARRQLV DEVMCTRKLQ VQEKLQREAK EQEERAMEQK HINESLKELN CEEKENFARR QRLAQEYRKQ LQMQIAYQQQ SQEAEKEEKR REFEAGVAAN KMCLDKVQEV LSTHQVLPQN IHPMRKACPS KLPP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.
  • 基因功能参考文献：
    1. CCDC11 is a cilium-associated gene with a role in left-right patterning in Xenopus and in laterality disorders in humans PMID: 28621423
    2. Cfap53 is a conserved regulator of organ laterality in both humans and zebrafish. PMID: 26531781
    3. CCDC11 has a conserved essential function in cilia of the vertebrate left-right organizer during embryogenesis. PMID: 25504577
    4. The s suggest that CCDC11 is associated with autosomal recessive laterality defects of diverse phenotype resulting in SIT in one individual family member who is otherwise healthy, and in complex laterality anomalies (HS) in another member. PMID: 22577226
  • 相关疾病：
    Heterotaxy, visceral, 6, autosomal (HTX6)
  • 亚细胞定位：
    Cell projection, cilium.
  • 蛋白家族：
    CFAP53 family
  • 组织特异性：
    Expressed in skin fibroblasts (at protein level).
  • 数据库链接：

    HGNC: 26530

    OMIM: 614759

    KEGG: hsa:220136

    STRING: 9606.ENSP00000381553

    UniGene: Hs.658630