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  4. Recombinant Human Coiled-coil domain-containing protein 67 (CCDC67)

Recombinant Human Coiled-coil domain-containing protein 67 (CCDC67)

  • 中文名称：
    人DEUP1重组蛋白
  • 货号：
    CSB-YP004729HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DEUP1重组蛋白
  • 货号：
    CSB-EP004729HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DEUP1重组蛋白
  • 货号：
    CSB-EP004729HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DEUP1重组蛋白
  • 货号：
    CSB-BP004729HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DEUP1重组蛋白
  • 货号：
    CSB-MP004729HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DEUP1
  • Uniprot No.：
  • 别名：
    DEUP1; CCDC67; Deuterosome assembly protein 1; Coiled-coil domain-containing protein 67
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-604
  • 氨基酸序列
    MENQAHNTMG TSPCEAELQE LMEQIDIMVS NKKMDWERKM RALETRLDLR DQELANAQTC LDQKGQEVGL LRQKLDSLEK CNLAMTQNYE GQLQSLKAQF SKLTNNFEKL RLHQMKQNKV PRKELPHLKE EIPFELSNLN QKLEEFRAKS REWDKQEILY QTHLISLDAQ QKLLSEKCNQ FQKQAQSYQT QLNGKKQCLE DSSSEIPRLI CDPDPNCEIN ERDEFIIEKL KSAVNEIALS RNKLQDENQK LLQELKMYQR QCQAMEAGLS EVKSELQSRD DLLRIIEMER LQLHRELLKI GECQNAQGNK TRLESSYLPS IKEPERKIKE LFSVMQDQPN HEKELNKIRS QLQQVEEYHN SEQERMRNEI SDLTEELHQK EITIATVTKK AALLEKQLKM ELEIKEKMLA KQKVSDMKYK AVRTENTHLK GMMGDLDPGE YMSMDFTNRE QSRHTSINKL QYENERLRND LAKLHVNGKS TWTNQNTYEE TGRYAYQSQI KVEQNEERLS HDCEPNRSTM PPLPPSTFQA KEMTSPLVSD DDVFPLSPPD MSFPASLAAQ HFLLEEEKRA KELEKLLNTH IDELQRHTEF TLNKYSKLKQ NRHI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis.
  • 基因功能参考文献：
    1. Single nucleotide polymorphism in CCDC67 gene is associated with Acute Renal Graft Rejection. PMID: 27272414
    2. Loss of CCDC67 is associated with papillary thyroid carcinoma. PMID: 26716505
    3. suggest that CCDC67 is a putative tumor suppressor gene that is silenced in gastric cancers by promoter CpG methylation and that it may play an important role in cell signaling and migration related to tumorigenesis PMID: 22610074
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    CEP63 family
  • 数据库链接：

    HGNC: 26344

    KEGG: hsa:159989

    STRING: 9606.ENSP00000298050

    UniGene: Hs.436625