Recombinant Human Connector enhancer of kinase suppressor of ras 2 (CNKSR2), partial
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货号:CSB-YP005653HU
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规格:¥1500
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图片:
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其他:
产品详情
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纯度:Greater than 90% as determined by SDS-PAGE.
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基因名:CNKSR2
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Uniprot No.:
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别名:CNKSR2; CNK2; KIAA0902; KSR2Connector enhancer of kinase suppressor of ras 2; Connector enhancer of KSR 2; CNK homolog protein 2; CNK2
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种属:Homo sapiens (Human)
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蛋白长度:Partial
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来源:Yeast
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分子量:19.1kDa
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表达区域:650-800aa
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氨基酸序列AAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAI
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. -
蛋白标签:N-terminal 6xHis-tagged
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产品提供形式:Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
缓冲液:Tris-based buffer,50% glycerol
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储存条件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保质期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事项:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet & COA:Please contact us to get it.
引用文献
- Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression David D.et al,BMC Cancer,2018
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靶点详情
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功能:May function as an adapter protein or regulator of Ras signaling pathways.
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基因功能参考文献:
- High CNKSR2 expression is associated with breast cancer progression. PMID: 29534682
- CNKSR2 deletions: a novel cause of X-linked intellectual disability and seizures. PMID: 25754917
- This study describes the phenotype of CNKSR2 deficiency and its involvement in systems underlying common neurological PMID: 25223753
- CNK2 through interaction with Raf and Rlf may function as a regulator of Ras signaling. PMID: 14597674
- CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling. PMID: 18287031
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亚细胞定位:Cytoplasm. Membrane; Peripheral membrane protein.
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蛋白家族:CNKSR family
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数据库链接:
HGNC: 19701
OMIM: 300724
KEGG: hsa:22866
STRING: 9606.ENSP00000368824
UniGene: Hs.555917
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