Recombinant Human Corticoliberin (CRH)

1. Early-preterm birth showed a syndrome of high maternal CRH and low vitamin D status. PMID: 28780891
2. REVIEW: CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response PMID: 28260504
3. REVIEW: Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract PMID: 28240194
4. REVIEW: The Multi-faceted Profile of Corticotropin-releasing Factor (CRF) Family of Neuropeptides and of their Receptors on the Paracrine/Local Regulation of the Inflammatory Response PMID: 28103784
5. Significant effects of CNS sensitization on CRF mRNA levels were detected in the Dorsal Striatum (increasing effect). PMID: 29857328
6. These results show epigenetic changes in the CRH gene related to severity of suicide attempt in adults and a general psychiatric risk score in adolescents. PMID: 29277323
7. Data suggest that corticotrophin-releasing hormone (CRH) is able to stimulate copeptin release in healthy controls suggesting direct interaction of CRH/CRH-receptor signaling and vasopressin; these interactions appear to be altered in patients with pituitary disease; copeptin may be serum biomarker of altered CRH/CRH-receptor signaling in pituitary diseases. PMID: 28795329
8. The development of disorders related to heightened stress sensitivity and dysregulation of stress-coping mechanisms appears to involve regulatory mechanisms of the CRH family members. The purpose of this review is to summarize the most significant discoveries related to CRH over time. [review] PMID: 28071586
9. A significant increase in CRH and CRHR-1 expression was significantly correlated with psychological stress in vitiligo. PMID: 27663146
10. Corticotrophin-releasing hormone accelerated tumor angiogenesis by upregulating VEGF expression and secretion in colon cancer cells. PMID: 28618089
11. This study found that the expressions of CRH and CRHR1 were significantly higher in the epileptogenic tissues of patients with IS than in the control group. PMID: 27534449
12. The s propose that conditions impacting on epiallele distribution influence the number of transcriptionally active CRH gene copies in the trophoblast cell population determining the gestational trajectory of placental CRH production in normal and pathological pregnancies. PMID: 28151936
13. Neuroimmune-endocrine events may lead to overactivity of sympathetic nervous system that triggers cascade of pathologic conditions in ovary in polycystic ovary syndrome (PCOS). Data suggest that women with PCOS exhibit reduction of CRH and NGF; reduction of CRH and NGF may be under influence of sympathetic nervous system and may reflect deficit of neuronal stress-adaptation in PCOS patients. (NGF = nerve growth factor) PMID: 27908212
14. brain activation in response to colorectal distention is enhanced after CRH injection in Irritable bowel syndrome patients compared to healthy controls PMID: 27448273
15. In deep infiltrating endometriotic lesions, CRH, Ucn and CRH-R2 mRNA levels were significantly higher than in ovarian endometrioma. PMID: 27567427
16. In summary, cardiac expression of CRFR1, CRF, and Ucn3 genes is elevated in heart failure and may contribute to the activation of the CRF/Ucn system in these patients. PMID: 27754786
17. VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts. PMID: 26818776
18. This study localized a complete CRF system in the human fetal heart. PMID: 27377597
19. Placenta CRH mRNA concentration appears to convey information about the risk of brain damage in the infant born at an extremely low gestational age. PMID: 26331704
20. These results suggest that the CRH and CRH-BP genes have no direct effect on Irritable bowel syndrome status. PMID: 26882083
21. This study evaluated the associations of CRH polymorphisms with susceptibility to MDD and response to antidepressant treatment PMID: 26055202
22. results suggest that glucocorticoids induce a transcription complex consisting of RelB/p52, CBP, and HDAC1 that triggers a dynamic acetylation-mediated epigenetic change to induce CRH expression in full-term human placenta. PMID: 26307012
23. Interaction of RelB with the CRH or COX-2 gene promoters decreased when STAT3 was depleted. PMID: 25771405
24. the present study demonstrates that the expression of CRH/CRH-R1 in lesions of chronic plaque psoriasis is lower than that in psoriatic perilesional skin and normal control skin. PMID: 25630718
25. results show that activation of CRH receptors by CRH ligands stimulates VEGF-A expression in intestinal epithelial cells through the cAMP/CREB pathway PMID: 26350463
26. This corticotropin releasing factor-induced regulation on norepinephrine transporter expression and function may play a role in development of stress-related depression and anxiety PMID: 26212818
27. Placental CRH exposure may make a unique contribution to fetal programming of obesity risk. PMID: 25591114
28. Data suggest that signal transduction involving corticotropin-releasing factor (CRH) and CRH receptors (CRHR) taking place in cochlea are involved in protecting against noise-induced hearing loss. [REVIEW] PMID: 26074267
29. Production of CRF and UCN1 in human dendritic cells is strongly augmented by commensal intestinal bacteria. PMID: 25339828
30. we show that Abeta species can hyperexcite CRF neurons, providing a mechanism by which Abeta influences stress-related symptoms PMID: 25673853
31. High serum corticotropin-releasing hormone (CRH) and bone marrow mast cell CRH receptor expression in a mastocytosis patient. PMID: 24985398
32. Corticotrophin-Releasing Factor (CRF) and the urocortins are potent regulators of the inflammatory phenotype of human and mouse white adipocytes. PMID: 24835211
33. Results suggest that ULBP2 is expressed and released from cervical cancer cells by CRF, which regulates NKG2D expression in natural killer cells. PMID: 24841552
34. This review focuses on the CRF receptor, a stress-related peptide implicated in diverse psychiatric and medical disorders that are more prevalent in females in diverse psychiatric and medical disorders that are more prevalent in females. PMID: 23849813
35. evidence suggests that CRH regulates neurogenesis in the brain. PMID: 23380766
36. as labor progresses, progesterone and corticotropin-releasing hormone increase and subsequently decrease precipitously in the immediate postpartal period PMID: 24597258
37. Data suggest that expression of CRF, CRF-related neuropeptides, and CRF receptors in the liver plays crucial regulatory roles in homeostasis, in allostasis to endogenous stresses, and in adaptation to exogenous stress stimuli. [REVIEW] PMID: 23933692
38. During the midluteal phase of the cycle, metformin may decrease the production of CRH and urocortin in the endometrium. PMID: 23987517
39. in human melanoma HMV-II cells both CRF and Ucn1 regulate TRP1 gene expression via Nurr-1/Nur77 production, independent of pro-opiomelanocortin or alpha-melanocyte-stimulating hormone stimulation. PMID: 23416839
40. IL-6 and CRH are both secreted in a pulsatile fashion during the active phase of human labor. The time-integrated concentrations of the two hormones are positively correlated, with IL-6 leading CRH secretion. PMID: 23928667
41. ERK1/2 activation in response to CRH is biphasic, involving a first cAMP- and B-Raf-dependent early phase and a second phase that critically depends on CRHR1 internalization and beta-arrestin2. PMID: 23371389
42. corticotrophin-releasing hormone (CRH) might play a significant role in the pathogenesis of intrahepatic cholestasis of pregnancy(ICP) and provide a new approach to further investigate the etiology of ICP PMID: 23478074
43. A novel CRH missense mutation (Pro30Arg) results in reduced levels of protein secretion in the short time thus suggesting that mutated people could present an altered capability to respond immediately to stress agents. PMID: 23593457
44. CRH/CRHR1 are involved in regulation of PGHS2 (prostaglandin-endoperoxide synthase 2) expression in myometrium before/during labor; these actions appear important in priming myometrium for labor and adaptive responses to inflammatory mediators. PMID: 23666959
45. Data suggest that CRF plays role in acute postinjury gut dysfunction; CRF is expressed in small bowel of elective/emergency gastrointestinal (GI) surgery patients with concomitant GI dysfunction; plasma CRF correlates with poor gastric emptying. PMID: 23466050
46. Postnatally stressed adult transgenic mice have decreased hippocampal nectin-3 levels, which could be attenuated by CRHR1 inactivation and mimicked by corticotropin-releasing hormone (CRH) overexpression in forebrain neurons. PMID: 23644483
47. the age-associated changes in the expression of CRH system components reflect an exaggerated stress response reaction, putting the aged skin continuously in a stress-like situation. PMID: 22533365
48. CRH may be involved in the pathogenesis of gastric cancer PMID: 23477585
49. study demonstrates that the HeLa cervical cancer cell line expresses CRH; additionally, CRH was shown to induce FasL expression PMID: 23076876
50. The aberrant expression of corticotropin-releasing hormone in pre-eclampsia may activate the FasL-positive decidual macrophages, impair the physiological turnover of extravillous trophoblasts, and eventually disturb placentation. PMID: 22763913

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HGNC: 2355

OMIM: 122560

KEGG: hsa:1392

STRING: 9606.ENSP00000276571

UniGene: Hs.75294