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  4. Recombinant Human Corticotropin-releasing factor receptor 2 (CRHR2), partial

Recombinant Human Corticotropin-releasing factor receptor 2 (CRHR2), partial

  • 货号：
    CSB-YP623797HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP623797HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP623797HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP623797HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP623797HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CRHR2; CRF2R; CRH2R; Corticotropin-releasing factor receptor 2; CRF-R-2; CRF-R2; CRFR-2; Corticotropin-releasing hormone receptor 2; CRH-R-2; CRH-R2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
  • 基因功能参考文献：
    1. A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction. PMID: 29953524
    2. CRF2 signaling induces alterations in both the epithelium permeability and the differentiation of human colonic carcinoma cell lines. PMID: 28811708
    3. Data show that corticotropin releasing hormone receptor 2 (Crhr2) protein is abundantly expressed in the heart, and plasma Ucn2 levels were higher in patients with heart failure compared to healthy controls, indicating that endogenous Crhr2 is associated with heart failure. PMID: 28550160
    4. Taken together, our data indicate that sex shows significant interaction with genotype and Ucn1 during colitis. Human duodenal and colonic biopsies revealed that sex-specific differences exist in levels of CRF receptors and Ucn1 expression in patients with CD compared with the matched non-IBD subjects. To conclude, Ucn1 mediates sex-specific immune and cellular signaling responses via CRF2, emphasizing the need for inclus PMID: 27053649
    5. Endogenous CRF may be involved in the pathogenesis of ischemia/reperfusion-induced enteritis, possibly via the activation of peripheral CRF receptor 2 PMID: 28011950
    6. This study showed that two CRHR2 variants (rs4722999-C and rs12701020-C) in BPD subjects with sexual and physical abuse. PMID: 26182893
    7. found associations between CRHR2 genotypes and haplotypes and negative emotion in IBS patients and controls PMID: 26808377
    8. Wound healing and signal transducer and activator of transcription 3 activity were elevated in CRHR2-overexpressing cells after urocortin 2 and IL-6 treatment, suggesting advanced healing progression PMID: 26597886
    9. This study demonstrated that CRF2 Receptor Deficiency Eliminates the Long-Lasting Vulnerability of Motivational States Induced by Opiate Withdrawal. PMID: 25672976
    10. D1 and CRF2 alpha receptors are capable of heterodimerization in living cells. D1 /CRF2 alpha receptor heteromerization might account, at least in part, for the complex physiological interactions established between dopamine and CRH. PMID: 25073922
    11. no difference in placental expression between intrahepatic cholestasis of pregnancy and controls PMID: 25172671
    12. not up-regulated by labor in placenta, fetal membranes, or myometrium PMID: 25426872
    13. HSF2 element confers estrogen up-regulation of CRHR2 transcription and estrogen increases CRHR2 transcription via induction of HSF2 demethylation. PMID: 24485608
    14. Results suggest CRHR-2 variants may affect risk for PTSD in women by attenuating the stress response and reducing symptoms of the disorder. PMID: 24123648
    15. The rate and extent of homologous CRF2(a) receptor desensitization is governed by agonist-specific mechanisms affecting G protein-coupled receptor kinase phosphorylation. PMID: 23820308
    16. CRFR2 antagonist astressin-2B abrogated the effects of UCN2 on VSMCs. In conclusion, UCN2 is significantly associated with AAA and inhibits VSMC proliferation by inducing a G1 cell cycle arrest suggesting a plausible regulatory role in AAA pathogenesis PMID: 24107226
    17. The down-regulation of the CRF2 receptor in the distal/sigmoid biopsies of ulcerative colitis patients is indicative of change in CRF2 signalling associated with the process of inflammation. PMID: 23539366
    18. Polymorphisms within CRHR1 and CRHR2 genes interacted with both childhood sexual abuse and emotional neglect to influence Iowa Gambling Task performance. PMID: 23177644
    19. Suggest that urocortin 1 increase LPS-induced endothelial permeability by disrupting the VE-cadherin-beta-catenin complex via activation of CRHR2. PMID: 23168683
    20. These findings reveal a complex interplay between the signaling molecules that allow "fine-tuning" of CRH-R2beta functional responses and regulate signal integration. PMID: 21338628
    21. nuclear translocation of Ucn along with the loss of CRFR2 in epithelial cells and microvasculature of tumoral specimens may be involved in the pathobiology of renal cell carcinoma PMID: 19437022
    22. Trophoblast cell cultures treated with increasing amounts of type 2 corticotrophin releasing hormone receptor mediate increased secretion of estradiol in the presence of androstenedione. PMID: 19417223
    23. Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor. PMID: 20966082
    24. There is no significant difference between the expression of CRH-R2beta mRNA of preeclampsia and of normal pregnancies. PMID: 15924674
    25. Investigated whether a genetic variation in CRHR2 gene might be associated with preterm birth. The polymorphism does not increase the risk for preterm birth overall but might modulate the length of pregnancy in a dose dependent fashion in Caucasian women. PMID: 20164545
    26. Results suggest that the rs2267716 polymorphism in the CRHR2 gene might influence the risk of developing HCC in patients with HBV infection in Chinese population. PMID: 19813023
    27. data suggest a distinctive role for corticotropin-releasing hormone receptor 2 specific agonists like urocortin II in the control of myometrial contractility during human pregnancy PMID: 14592950
    28. The regions of the CRF2(a) promoter that regulate the inducible expression were determined PMID: 15331578
    29. ligand binding properties of CRFR2 PMID: 15652653
    30. expression by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescent immunocytochemistry in umbilical cord blood-derived cultured mast cells PMID: 16326828
    31. CRHR2 polymorphisms examined do not confer susceptibility to panic disorder. PMID: 16691126
    32. Results demonstrate corticotropin-releasing factor (2) expression in the human gastric mucosa and indicate a physiological role of this receptor type in regulating apoptosis, an important parameter of gastric cell regeneration. PMID: 16972272
    33. results show that haplotype variation at the CRHR2 locus is associated with suicidal behaviour PMID: 17532191
    34. Human myometrium expresses both CRH-R1 and CRH-R2 during pregnancy. PMID: 17959885
    35. Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma. PMID: 18408560
    36. UCN inhibited the proliferation and promoted the apoptosis of endothelial cells and down-regulated VEGF expression in vivo via CRFR2. PMID: 18443956
    37. Expression loss of CRFR2 in prostate cancer and its neovascularization contributes to prostate tumorigenesis, progression, and neoangiogenesis. PMID: 19058138
    38. receptors couple to different G-proteins in stably transfected human cells, leading to transient divalent calcium ion mobilization on top of the natural increase in cyclic AMP stimulation. PMID: 19098121
    39. the SCP/CRHR2 system is present in human ovaries and treatment with SCP/Ucn3 inhibits progesterone production by cultured granulosa-lutein cells through interaction with CRHR2 PMID: 19351656

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 数据库链接：

    HGNC: 2358

    OMIM: 602034

    KEGG: hsa:1395

    STRING: 9606.ENSP00000340943

    UniGene: Hs.546246