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  4. Recombinant Human Cysteine and histidine-rich domain-containing protein 1 (CHORDC1)

Recombinant Human Cysteine and histidine-rich domain-containing protein 1 (CHORDC1)

  • 中文名称：
    Recombinant Human Cysteine and histidine-rich domain-containing protein 1(CHORDC1),Yeast
  • 货号：
    CSB-YP887031HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Cysteine and histidine-rich domain-containing protein 1(CHORDC1),Yeast
  • 货号：
    CSB-EP887031HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Cysteine and histidine-rich domain-containing protein 1(CHORDC1),Yeast
  • 货号：
    CSB-EP887031HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Cysteine and histidine-rich domain-containing protein 1(CHORDC1),Yeast
  • 货号：
    CSB-BP887031HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Cysteine and histidine-rich domain-containing protein 1(CHORDC1),Yeast
  • 货号：
    CSB-MP887031HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CHORDC1
  • Uniprot No.：
  • 别名：
    CHORD containing protein 1; Chord domain containing protein 1; CHORD domain-containing protein 1; CHORD-containing protein 1; CHORDC1; CHP-1; CHP1; CHRD1_HUMAN; Cysteine and histidine rich domain (CHORD) containing 1; Cysteine and histidine rich domain (CHORD) containing, zinc binding protein 1; Cysteine and histidine rich domain containing 1; Cysteine and histidine rich domain containing zinc binding protein 1; Cysteine and histidine-rich domain-containing protein 1; FLJ37289; Protein morgana
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-332
  • 氨基酸序列
    ALLCYNRGC GQRFDPETNS DDACTYHPGV PVFHDALKGW SCCKRRTTDF SDFLSIVGCT KGRHNSEKPP EPVKPEVKTT EKKELCELKP KFQEHIIQAP KPVEAIKRPS PDEPMTNLEL KISASLKQAL DKLKLSSGNE ENKKEEDNDE IKIGTSCKNG GCSKTYQGLE SLEEVCVYHS GVPIFHEGMK YWSCCRRKTS DFNTFLAQEG CTKGKHMWTK KDAGKKVVPC RHDWHQTGGE VTISVYAKNS LPELSRVEAN STLLNVHIVF EGEKEFDQNV KLWGVIDVKR SYVTMTATKI EITMRKAEPM QWASLELPAA KKQEKQKDAT TD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling. Involved in stress response. Prevents tumorigenesis.
  • 基因功能参考文献：
    1. NF-kappaB activation in breast cancer cells depends on the presence of the CHORDC1 gene product Morgana. PMID: 29158506
    2. suppression of miR-26b expression up-regulates its target gene CHORDC1, which increases HBV enhancer/promoter activities and promotes viral transcription, gene expression, and replication PMID: 25342750
    3. morgana causes PTEN destabilization, by inhibiting ROCK activity PMID: 24615293
    4. A novel ADP-dependent HSP90 interaction with the cysteine- and histidine-rich domain (CHORD)-containing protein CHORDC1, is characterized. PMID: 19875381
    5. This paper described the cloning of a barley CHORD containing protein, but it also described the CHORD containing proteins in other species including human and characterized the CHORD domains. PMID: 10571178

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  • 组织特异性：
    Underexpressed in many breast and lung cancers.
  • 数据库链接：

    HGNC: 14525

    OMIM: 604353

    KEGG: hsa:26973

    STRING: 9606.ENSP00000319255

    UniGene: Hs.112482