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  4. Recombinant Human Dapper homolog 2 (DACT2)

Recombinant Human Dapper homolog 2 (DACT2)

  • 货号：
    CSB-YP725552HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP725552HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP725552HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP725552HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP725552HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DACT2
  • Uniprot No.：
  • 别名：
    bA503C24.7; C6orf116; Chromosome 6 open reading frame 116 ; Dact2; DACT2_HUMAN; Dapper antagonist of beta catenin homolog 2; Dapper antagonist of beta catenin homolog 2 Xenopus laevis; Dapper homolog 2 antagonist of beta catenin ; Dapper homolog 2 antagonist of beta catenin xenopus ; Dapper homolog 2; DAPPER2; DPR2; FLJ31232 ; MGC133141; MGC133142 ; RP11 503C24.7
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-774
  • 氨基酸序列
    MWTPGGPPGS AGWDRRRLGA RLRAAFAGLQ ELQGLRATQQ ERVRGALALQ PPPAPAAPCG PHGLHGPEQQ LEAALAALQE QLSRLRQQDI GLKTHLDQLD LQISKLQLDV GTASGEALDS DSRPSSGFYE MSDGGSCSLS TSCASVCSDH ISPSLGSLLP VAQAHKARPS MGDWRPRSVD ETTVPAWRPQ ATEEGARPPG SVEDAGQPWG TFWPRPVSTG DLDRALPADT GLQKASADAE LLGLLCQGVD IPLHVPDPKY RQDLVSQGGR EVYPYPSPLH AVALQSPLFV LTKETPQRGG PSFPRESPRG PAGLNTIQTG PVLEAGPARA RAYIDRLLHL WGRETPAKGS EGEQGPLRHA ASPSPQRQGG WSTDGGGRLL VFAPGREDEG GPAQSRGAGR GGPQQQGYMP LEGPQQSGSL PEEGSKPSNS CVLRETMVQA SPSSKAQQTP SAQDYGRGNI ISPSRMLDKS PSPASGHFAH PSFAASLKMG PPKSKAEKIK RSPMDKVLRF ARQPLLLLDR PEGAHAAPQP SLEWDPAHWP TGRGGLQRRP ALAWEAPGRS CSESTLYPMP VLVPLAVAPQ ESHRTSAQAL FPFEASLLTS VARRKHRRWQ STVEISARAR LASCPESNLG PPRPVARRAG GPLARGRPSL VRQDAYTRSD SEPSKHSAEC DPRFPSVIPE TSEGESSDHT TNRFGDRESS SSDEEGGAQS RDCDLALGYV AAGHAELAWT QEAPVSSGPL LSPVPKLCRI KASKALKKKI RRFQPTALKV MTMV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling.
  • 基因功能参考文献：
    1. Results demonstrate that DACT2 functions as a tumor suppressor for breast cancer but was frequently disrupted epigenetically in this cancer. PMID: 27708215
    2. The simultaneous methylation of DACT1 and DACT2 may play important roles in progression of ESCC and may serve as prognostic methylation biomarkers for ESCC patients. PMID: 28077137
    3. DACT2 is frequently methylated in human esophageal cancer and its expression is regulated by promoter region methylation. DACT2 suppresses esophageal cancer growth by inhibiting Wnt signaling. PMID: 26919254
    4. This study demonstrated that Genes overexpressed in Pilomyxoid Astrocytoma vs. Pilocytic Astrocytoma, ranked according to fold-change, included developmental genes H19, DACT2,COL2A1; COL1A1 and IMP3. PMID: 25521223
    5. DACT2 suppresses papillary thyroid cancer proliferation and metastasis by inhibiting Wnt signaling. PMID: 25375359
    6. There was no statistical difference between groups concerning DACT1 and DACT2 either in promoter hypermethylation or transcript levels. Age was associated with DACT2 promoter hypermethylation, especially over 56 years old. PMID: 25524937
    7. DACT2 acts as a functional tumor suppressor in colon cancer through inhibiting Wnt/beta-catenin signaling. Its methylation at early stages of colon carcinogenesis is an independent prognostic factor. PMID: 25023701
    8. DACT2 suppresses hepatocellular carcinoma by inhibiting Wnt signaling in human hepatocellular carcinoma cells. PMID: 23449122
    9. Loss of DACT2 expression is associated with esophageal squamous cell carcinoma. PMID: 23803417
    10. Reduced expression of DACT2 due to methylation-mediated gene silencing promotes hepatocellular carcinoma progression PMID: 23496880
    11. Epigenetic regulation of DACT2 is a key component of the Wnt signalling pathway in human lung cancer. PMID: 22806826
    12. Hypermethylation of Dact1 gene is associated with transitional cell carcinomas. PMID: 23244112
    13. Nuclear beta-catenin was more frequently expressed in non-polypoid growth low grade colorectal neoplasms than in polypoid growth neoplasms. PMID: 18370954

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  • 蛋白家族：
    Dapper family
  • 数据库链接：

    HGNC: 21231

    OMIM: 608966

    KEGG: hsa:168002

    STRING: 9606.ENSP00000355760

    UniGene: Hs.673059