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  4. Recombinant Human Dead end protein homolog 1 (DND1)

Recombinant Human Dead end protein homolog 1 (DND1)

  • 中文名称：
    人DND1重组蛋白
  • 货号：
    CSB-YP809023HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DND1重组蛋白
  • 货号：
    CSB-EP809023HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DND1重组蛋白
  • 货号：
    CSB-BP809023HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DND1重组蛋白
  • 货号：
    CSB-MP809023HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DND1
  • Uniprot No.：
  • 别名：
    Dead end homolog 1 (zebrafish); dead end homolog 1; Dead end protein; Dead end protein homolog 1; Dead end; zebrafish; homolog; 1; DND microRNA-mediated repression inhibitor 1; dnd1; DND1_HUMAN; MGC34750; RBMS4; RNA binding motif single stranded interacting protein 4; RNA-binding motif; single-stranded-interacting protein 4; Ter
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-353
  • 氨基酸序列
    MQSKRDCELW CERVNPENKA ALEAWVRETG IRLVQVNGQR KYGGPPPGWV GSPPPAGSEV FIGRLPQDVY EHQLIPLFQR VGRLYEFRLM MTFSGLNRGF AYARYSSRRG AQAAIATLHN HPLRPSCPLL VCRSTEKCEL SVDGLPPNLT RSALLLALQP LGPGLQEARL LPSPGPAPGQ IALLKFSSHR AAAMAKKALV EGQSHLCGEQ VAVEWLKPDL KQRLRQQLVG PFLRSPQPEG SQLALARDKL GFQGARATLQ LLCQRMKLGS PVFLTKCLGI GPAGWHRFWY QVVIPGHPVP FSGLIWVVLT LDGRDGHEVA KDAVSVRLLQ ALSESGANLL WSAGAEAGTM VKQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival. However, does not seem to be essential for PGC migration.
  • 基因功能参考文献：
    1. Mechanistically, Dnd1 could bind to 3'-UTR of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP and its cytoplasmic retention. PMID: 28593479
    2. Dnd1 facilitates apoptosis by increasing the expression of Bim via its competitive combining with miR-221 in Bim-3'UTR. PMID: 28191469
    3. RBM38 and DND1 are repressed in primary acute myeloid leukemia, neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1) expression during acute promyelocytic leukemia differentiation PMID: 26740055
    4. APOBEC3G inhibits DND1 function to regulate microRNA activity. PMID: 23890083
    5. The increased sensitivity of transformed keratinocytes to miR-21's effects occurs in part through downregulation of the RNA-binding protein DND1 during the transformation process. PMID: 22614019
    6. Results suggest that DND1 may impose another level of translational regulation to modulate expression of critical factors in ES cells. PMID: 21851623
    7. We conclude that germline DND1 mutations are unlikely to contribute significantly to human testicular germ cell tumor susceptibility PMID: 20411342
    8. Cloning of zebrafish dnd1 and identification of human DND1 by database analysis. PMID: 12932328
    9. Unravels a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression. PMID: 18155131
    10. MiR-24 up-regulation reduced the expression of RNA-binding protein dead end 1 (DND1). Knockdown of miR-24 led to enhanced expression of DND1. PMID: 20816961
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 20411342
    12. The variant, p. Glu86Ala, found in only one case of testiciular germ cell tumor, is within a known functional domain of DND1 and is highly conserved through evolution; mutations in DND1 make, at most, a very small contribution to TGCT susceptibility PMID: 18069663
    13. Observational study of gene-disease association. (HuGE Navigator) PMID: 18069663

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 数据库链接：

    HGNC: 23799

    OMIM: 609385

    KEGG: hsa:373863

    STRING: 9606.ENSP00000445366

    UniGene: Hs.591262